WormBase Tree Display for Gene: WBGene00000693

WBGene00000693 Evidence: Person_evidence: WBPerson345
      WBPerson651
  SMap: S_parent: Sequence: C53B4
  Identity: Version: 1
    Name: CGC_name: col-119 Person_evidence: WBPerson345
      Sequence_name: C53B4.5
      Molecular_name: C53B4.5
        C53B4.5.1
        CE03091
      Other_name: CELE_C53B4.5 Accession_evidence: NDB BX284604
      Public_name: col-119
    DB_info: Database: AceView gene 4J744
        WormQTL gene WBGene00000693
        WormFlux gene WBGene00000693
        NDB locus_tag CELE_C53B4.5
        Panther gene CAEEL|WormBase=WBGene00000693|UniProtKB=Q18799
          family PTHR24637
        NCBI gene 177715
        RefSeq protein NM_069160.6
        TrEMBL UniProtAcc Q18799
        UniProt_GCRP UniProtAcc Q18799
        OMIM gene 120090
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: col
    Allele (23)
    RNASeq_FPKM (74)
    GO_annotation: 00062326
      00062327
      00062328
      00107685
    Ortholog (28)
    Paralog (163)
    Structured_description: Automated_description: Predicted to be a structural constituent of cuticle. Predicted to be located in membrane. Predicted to be part of collagen trimer. Human ortholog(s) of this gene implicated in artery disease (multiple); brain small vessel disease 2; and porencephaly. Is an ortholog of human COL4A2 (collagen type IV alpha 2 chain). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0112314 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2203)
      DOID:0060263 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2203)
      DOID:13223 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2203)
      DOID:13129 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2203)
      DOID:1936 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2203)
  Molecular_info: Corresponding_CDS: C53B4.5
    Corresponding_transcript: C53B4.5.1
    Other_sequence (258)
    Associated_feature: WBsf230494
      WBsf230495
  Experimental_info: RNAi_result (13)
    Expr_pattern: Expr1015422
      Expr1030414
      Expr1147036
      Expr2010316
      Expr2028560
    Drives_construct: WBCnstr00037363
    Construct_product: WBCnstr00037363
    Microarray_results (18)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032031:DConiospora_downregulated_OligoArray_24h
      WBPaper00033070:Elbe_upregulated
      WBPaper00033444:BacteriaDiet_regulated
      WBPaper00035269:cde-1_regulated
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038213:E.coli(LF82)_24h_downregulated
      WBPaper00038237:age-1_upregulated_intestine_rescue
      WBPaper00038237:age-1_upregulated_neuron_rescue
      WBPaper00038237:age-1_upregulated_nontransgenic
      WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040990:PA14_downregulated
      WBPaper00041954:ethanol_upregulated
      WBPaper00044037:eat-2_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:rising_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045316:prg-1_downregulated_L4
      WBPaper00045401:N.parisii_64h_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045861:wdr-5(ok1417)_downregulated
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046795:starvation_downregulated
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048785:heat-shock_downregulated
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049018:swsn-2.2(RNAi)_upregulated
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049635:dop-1(vs100)_downregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050412:cco-1(RNAi)_downregulated_met-2(ok2307)
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050686:glp-1(e2141)_upregulated
      WBPaper00050717:let-7(n2853)_lin-41(xe11)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051352:Long-Term-Association-Memory_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053154:human-amyloid-beta_tau_regulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00054410:set-26(tm2467)_downregulated
      WBPaper00054493:hpl-2(tm1489)_downregulated
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055060:flr-1(RNAi)_downregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055827:daf-2(e1370)_downregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00055944:C.butyricum_vs_OP50_downregulated
      WBPaper00055969:electromagnetic-field_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056039:efa-6(tm3124)_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056218:daf-16(mu86)_downregulated_Day5
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056290:mdt-15(mg584)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056868:P.aeruginosa_downregulated_smallRNA
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00058598:mex-1(or286)_downregulated
      WBPaper00058598:spn-4(tm291)_downregulated
      WBPaper00058711:paraquat_upregulated
      WBPaper00058711:skn-1(lax188)_downregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00058948:PA14_upregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059334:sacy-1(depletion)_regulated
      WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
      WBPaper00059739:hira-1(gk835598)_downregulated_adult
      WBPaper00059763:neuron_acr-2(n2420gf)_regulated
      WBPaper00059763:neuron_expressed
      WBPaper00060084:cco-1(RNAi)_downregulated_lin-40(yth27)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-extract_12h_regulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00060911:prx-5(RNAi)_downregulated_mRNA
      WBPaper00060921:cat-2(e1112)_downregulated
      WBPaper00060921:tdc-1(n3419)_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061393:C.albicans_regulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4747)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061527:col-178-col-19
      WBPaper00061527:R10H10.3-T21H3.1
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061653:alh-4(hj221)_downregulated
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062184:PA14_downregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062197:mec-8_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062354:H.zoospora_12h_regulated
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062440:crh-1(syb385)_upregulated
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064532:pals-25(icb98)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064735:mys-1(RNAi)_vs_N2_upregulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00064850:glh-1(sam65)_downregulated
      WBPaper00064871:PA14_upregulated_AWA
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065029:cadmium_downregulated
      WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_25C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065132:asna-1(ok938)_downregulated_protein
      WBPaper00065158:AFD_depleted
      WBPaper00065392:Lb.delbrueckii_downregulated
      WBPaper00065392:Lb.reuteri_upregulated
      WBPaper00065392:P.pentosaceus_upregulated
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065623:9
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_upregulated_N2
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065841:0_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_2_1
      cgc4489_group_2
      WBPaper00005124:progesterone_10-7M_regulated
      WBPaper00005124:testosterone_10-9M_regulated
      WBPaper00025032:cluster_141
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:Resveratrol_regulated_N2
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030985:Erwinia_carotovora_downregulated
      WBPaper00030985:Photorhabdus_luminescens_downregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032062:age_regulated_genes
      WBPaper00033101:spr-5_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_D
      WBPaper00036375:depleted_in_PVD_OLL
      WBPaper00036383:ash-2_Day8_regulated
      WBPaper00037113:CPF_16C_down-regulated
      WBPaper00037113:DZN_16C_down-regulated
      WBPaper00038172:aak-2overexpression_up_regulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00044535:male_downregulated
      WBPaper00045015:acs-3(ft5)_downregulated
      WBPaper00045015:nhr-25(RNAi)_downregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00047070:N2_UV_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (84)
  Map_info: Map: IV Position: 3.99997 Error: 4.9e-05
    Positive: Positive_clone: C53B4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (4)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene