| WBGene00000156 | SMap | S_parent | Sequence | K04G2 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | apr-1 | Person_evidence | WBPerson419 |
| | | Sequence_name | K04G2.8 |
| | | Molecular_name | K04G2.8a |
| | | | K04G2.8a.1 |
| | | | CE06102 |
| | | | K04G2.8b |
| | | | CE18016 |
| | | | K04G2.8c |
| | | | CE51809 |
| | | | K04G2.8b.1 |
| | | | K04G2.8c.1 |
| | | Other_name | APC | Paper_evidence | WBPaper00044307 |
| | | | CELE_K04G2.8 | Accession_evidence | NDB | BX284601 |
| | | Public_name | apr-1 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | apr |
| | Allele (69) |
| | Possibly_affected_by | WBVar02153202 |
| | Legacy_information | [Rocheleau CE] apr-1 for APC (adenomatous polyposis coli) Related gene. No mutants known, 26% of apr-1(RNAi) embryos lack endoderm, overproduce pharyngeal tissue, E divides prematurely, adopts MS-like fate. Predicted gene K04G2.8. Allele zh10 isolated, see below. [sdm 12/01] |
| | Strain | WBStrain00037280 |
| | | WBStrain00000140 |
| | | WBStrain00008585 |
| | | WBStrain00024309 |
| | RNASeq_FPKM (74) |
| | GO_annotation (77) |
| | Ortholog (41) |
| | Structured_description | Concise_description | The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39; APR-1 along with MOM-5/Frizzled receptor and GSK-3 kinase is also required for the engulfment of apoptotic cells and migration of the distal tip cell in the gonad, indicating that Wnt signaling can regulate cytoskeletal rearrangements via CED-10/RAC; phosphorylated APR-1 binds CED-2/CrkII in yeast two hybrid screens, this binding and genetic studies suggest that APR-1 and MOM-5 activate the CED-2/5/12 branch of the engulfment pathway. | Paper_evidence (12) |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 25 May 2011 00:00:00 |
| | | Automated_description | Enables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model (20) |
| Molecular_info | Corresponding_CDS (3) |
| | Corresponding_transcript | K04G2.8a.1 |
| | | K04G2.8b.1 |
| | | K04G2.8c.1 |
| | Other_sequence | AF013950 |
| | | CGC00612_1 |
| | | ACC25655_1 |
| | | EX555243.1 |
| | | CBC06635_1 |
| | Associated_feature | WBsf656598 |
| | | WBsf218114 |
| Experimental_info | RNAi_result (104) |
| | Expr_pattern | Expr1046 |
| | | Expr4600 |
| | | Expr12119 |
| | | Expr12448 |
| | | Expr15118 |
| | | Expr1028112 |
| | | Expr1030085 |
| | | Expr1153646 |
| | | Expr2009365 |
| | | Expr2027601 |
| | Drives_construct | WBCnstr00005188 |
| | | WBCnstr00007256 |
| | | WBCnstr00009075 |
| | | WBCnstr00009116 |
| | | WBCnstr00012108 |
| | | WBCnstr00016098 |
| | | WBCnstr00020198 |
| | | WBCnstr00021087 |
| | | WBCnstr00037698 |
| | Construct_product | WBCnstr00000526 |
| | | WBCnstr00007257 |
| | | WBCnstr00007258 |
| | | WBCnstr00009057 |
| | | WBCnstr00009075 |
| | | WBCnstr00012108 |
| | | WBCnstr00016098 |
| | | WBCnstr00020198 |
| | | WBCnstr00021087 |
| | | WBCnstr00037698 |
| | Antibody | WBAntibody00000276 |
| | | WBAntibody00000277 |
| | Microarray_results (25) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032031:DConiospora_upregulated_cDNA_24h |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051558:fog-2(q71)_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:stavudine_72h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057154:HeatShock_downregulated_mRNA |
| | | WBPaper00057154:HeatShock_upregulated_miRNA-target |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00058725:sftb-1(cer6)_upregulated |
| | | WBPaper00058886:anp-1(ok608)_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061340:Ciliated_non_amphid_neuron |
| | | WBPaper00061340:mc1 |
| | | WBPaper00061340:Neuroblast_ALA_RMED |
| | | WBPaper00061340:Neuroblast_ASJ_AUA |
| | | WBPaper00061340:OLQ_grandparent |
| | | WBPaper00061340:Parent_of_AMsh_URB |
| | | WBPaper00061340:Parent_of_tail_spike_and_hyp10 |
| | | WBPaper00061340:pm3_pm4_pm5 |
| | | WBPaper00061340:pm7 |
| | | WBPaper00061340:RID_parent |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064502:spe-44(fx110)_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065149:lin-52(n771)_upregulated |
| | | WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_6_4 |
| | | cgc4489_group_2 |
| | | WBPaper00025032:cluster_116 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:cluster_13 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(83_min) |
| | | [cgc5767]:expression_class_E_pi(101_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (179) |
| | WBProcess | WBbiopr:00000073 |
| Map_info | Map | I | Position | 2.43771 | Error | 0.002342 |
| | Positive | Positive_clone | K04G2 | Person_evidence | WBPerson524 |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4159 |
| | | | 4893 |
| | | | 5616 |
| | Pseudo_map_position |
| Reference (108) |
| Picture | WBPicture0000013084 |
| Remark (2) |
| Method | Gene |
