| WBGene00000055 | SMap | S_parent | Sequence | F25G6 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | acr-16 | Person_evidence | WBPerson1430 |
| | | Sequence_name | F25G6.3 |
| | | Molecular_name | F25G6.3 |
| | | | F25G6.3.1 |
| | | | CE09639 |
| | | Other_name | Ce21 |
| | | | CELE_F25G6.3 | Accession_evidence | NDB | BX284605 |
| | | Public_name | acr-16 |
| | DB_info | Database | AceView | gene | 5J43 |
| | | | WormQTL | gene | WBGene00000055 |
| | | | WormFlux | gene | WBGene00000055 |
| | | | NDB | locus_tag | CELE_F25G6.3 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00000055|UniProtKB=P48180 |
| | | | | family | PTHR18945 |
| | | | NCBI | gene | 179235 |
| | | | RefSeq | protein | NM_072806.5 |
| | | | SwissProt | UniProtAcc | P48180 |
| | | | UniProt_GCRP | UniProtAcc | P48180 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:19 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | acr |
| | Allele (37) |
| | Strain | WBStrain00031630 |
| | RNASeq_FPKM (74) |
| | GO_annotation (32) |
| | Ortholog (42) |
| | Paralog (100) |
| | Structured_description | Concise_description | acr-16 encodes an alpha-7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily orthologous to human nicotinic cholinergic receptor alpha 7 (CHRNA7; OMIM:118511; possibly associated with schizophrenia and juvenile myoclonic epilepsy); ACR-16 functions as a ligand-gated ion channel that is required for the major fast cholinergic excitatory current at C. elegans neuromuscular junctions; when expressed in Xenopus ooctyes, ACR-16 is active as a homomeric receptor and responds robustly to acetylcholine; an ACR-16::GFP reporter fusion expressed in muscle cells localizes to the tips of muscle arms, specific regions of the muscle cell membrane that form synapses with neuronal processes; acr-16::gfp promoter fusions also reveal expression in a subset of neurons; ACR-16 localization to postsynaptic regions, a key component of activity-dependent synaptic plasticity, is regulated by a Wnt signaling pathway that includes CWN-2, LIN-17, CAM-1, and DSH-1. | Paper_evidence | WBPaper00003425 |
| | | | | | WBPaper00004459 |
| | | | | | WBPaper00005427 |
| | | | | | WBPaper00005594 |
| | | | | | WBPaper00025245 |
| | | | | | WBPaper00040939 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 17 Apr 2012 00:00:00 |
| | | Automated_description | Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic ion transmembrane transport. Located in cell projection. Expressed in body wall musculature; linker cell; muscle cell; and neurons. Used to study nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; carcinoma (multiple); and inflammatory bowel disease (multiple). Is an ortholog of human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:0050742 | Homo sapiens | Paper_evidence | WBPaper00028761 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 22 May 2019 00:00:00 |
| | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) |
| | | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) |
| | | DOID:3748 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) |
| | | DOID:8778 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) |
| | | DOID:3083 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) |
| | | DOID:12217 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) |
| | | DOID:8577 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) |
| | | DOID:1324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) |
| | | DOID:7474 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) |
| | | DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) |
| Models_disease_asserted | WBDOannot00000676 |
| Molecular_info | Corresponding_CDS | F25G6.3 |
| | Corresponding_CDS_history (2) |
| | Corresponding_transcript | F25G6.3.1 |
| | Other_sequence (27) |
| | Associated_feature | WBsf1000696 |
| | | WBsf1000697 |
| | | WBsf232121 |
| Experimental_info | RNAi_result (11) |
| | Expr_pattern (13) |
| | Drives_construct | WBCnstr00004901 |
| | | WBCnstr00004902 |
| | | WBCnstr00004903 |
| | | WBCnstr00004904 |
| | | WBCnstr00004905 |
| | | WBCnstr00009872 |
| | | WBCnstr00011440 |
| | | WBCnstr00011957 |
| | | WBCnstr00017746 |
| | | WBCnstr00018183 |
| | Construct_product | WBCnstr00001360 |
| | | WBCnstr00006788 |
| | | WBCnstr00009355 |
| | | WBCnstr00011441 |
| | | WBCnstr00014504 |
| | | WBCnstr00020316 |
| | Antibody | WBAntibody00001986 |
| | Microarray_results (30) |
| | Expression_cluster | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_embryo_enriched |
| | | WBPaper00037950:AVE-neuron_embryo_SelectivelyEnriched |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00037950:glr-1(+)-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046805:csr-1(RNAi)_upregulated_Set1 |
| | | WBPaper00046805:csr-1(RNAi)_upregulated_Set2 |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050015:ifg-1(RNAi)_downregulated |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050370:dpy-21(e428)_L3_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055648:male-tail_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058711:wdr-5(ok1417)_upregulated |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00060084:cco-1(RNAi)_downregulated_N2 |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061040:eat-2(ad1116)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:mu_sph |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:URA_parent |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:rgs-2_11061-pde-1 |
| | | WBPaper00061651:AVA_enriched |
| | | WBPaper00062095:unc-4(e120)_upregulated_VA-neuron |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062590:Aging_downregulated_neuron |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064769:him-17(me24)_upregulated |
| | | WBPaper00064933:bcf-1(ylf1)_downregulated_transcript |
| | | WBPaper00065841:22_0 |
| | | WBPaper00065841:38_1 |
| | | WBPaper00065841:38_2 |
| | | WBPaper00065841:46_0 |
| | | WBPaper00065841:61_0 |
| | | WBPaper00065841:86_0 |
| | | WBPaper00065841:121_0 |
| | | WBPaper00065841:126_0 |
| | | WBPaper00065841:137_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | cgc4489_group_4 |
| | | cgc4489_group_14 |
| | | WBPaper00005124:testosterone_10-9M_regulated |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00037113:Diazinon_16C_regulated |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotype_environment_interaction |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | [cgc5376]:let-60(G12V)-regulated_genes |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(83_min) |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SET |
| | | [cgc5767]:expression_class_SE_pi(53_min) |
| | | [cgc6390]:mixed_oogenesis-somatic |
| | Interaction (28) |
| Map_info | Map | V | Position | 1.46223 | Error | 0.003864 |
| | Positive | Positive_clone | F25G6 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4869 |
| | | | 5605 |
| | Pseudo_map_position |
| Reference (89) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
