WormBase Tree Display for Gene: WBGene00006956

WBGene00006956 Evidence: Paper_evidence: WBPaper00003717
    Person_evidence: WBPerson83
  SMap: S_parent: Sequence: ZK1290
  Identity: Version: 1
    Name (5)
    DB_info: Database: AceView gene 2H824
        WormQTL gene WBGene00006956
        WormFlux gene WBGene00006956
        NDB locus_tag CELE_ZK1290.8
        NCBI gene 174224
        RefSeq protein NM_063179.5
        TREEFAM TREEFAM_ID TF315615
        TrEMBL UniProtAcc Q09635
        UniProt_GCRP UniProtAcc Q09635
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: wrt
    Allele (32)
    Strain: WBStrain00047059
      WBStrain00047060
    RNASeq_FPKM (74)
    Ortholog (29)
    Structured_description: Concise_description: wrt-10 encodes a hedgehog-like protein, with an N-terminal signalsequence, a Wart domain, and a C-terminal region of low-complexitysequence; WRT-10 is expressed in both male and hermaphrodite intestine;the Wart domain is predicted to form a cysteine-crosslinked proteininvolved in intercellular signalling, and it has subtle similarity tothe N-terminal Hedge domain of HEDGEHOG proteins; WRT-10 is required fornormal growth to full size and locomotion; both of these requirementsmay reflect common defects in cholesterol-dependent hedgehog-likesignalling or in vesicle trafficking. Paper_evidence: WBPaper00003717
            WBPaper00026629
            WBPaper00026841
            WBPaper00027263
          Curator_confirmed: WBPerson567
          Date_last_updated: 05 Nov 2006 00:00:00
      Automated_description: Expressed in hypodermis; interfacial epithelial cell; and intestine. Is predicted to encode a protein with the following domain: Phosphorylation site. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: ZK1290.8
    Corresponding_transcript: ZK1290.8.1
    Other_sequence (47)
    Associated_feature: WBsf650234
      WBsf665695
      WBsf665696
      WBsf988469
      WBsf1012547
      WBsf223348
      WBsf223349
      WBsf223350
  Experimental_info: RNAi_result: WBRNAi00059217 Inferred_automatically: RNAi_primary
      WBRNAi00038198 Inferred_automatically: RNAi_primary
      WBRNAi00021870 Inferred_automatically: RNAi_primary
      WBRNAi00077014 Inferred_automatically: RNAi_primary
      WBRNAi00076989 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3372
      Expr3387
      Expr4429
      Expr1012961
      Expr1032967
      Expr1162636
      Expr2018075
      Expr2036213
    Drives_construct: WBCnstr00011369
      WBCnstr00011991
      WBCnstr00034072
    Construct_product: WBCnstr00034072
    Microarray_results (18)
    Expression_cluster: WBPaper00032528:L3_enriched
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
      WBPaper00038118:stress_upregulated_N2
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00042477:prp-8(RNAi)_downregulated_RNAseq
      WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00043945:MeHg_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045257:bar-1(ga80)_downregulated
      WBPaper00045390:ubc-9(RNAi)_upregulated
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045420:fertilization_upregulated_transcript
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046499:AMPK_regulated
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00046805:csr-1(RNAi)_downregulated_Set2
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048611:MnCl2_upregulated
      WBPaper00048926:miaserin_upregulated_adult-day5
      WBPaper00048988:neuron_expressed
      WBPaper00049018:ham-3(RNAi)_upregulated
      WBPaper00049018:swsn-2.2(RNAi)_upregulated
      WBPaper00049098:heat-induced_hrde-1(tm1200)
      WBPaper00049134:hpk-1(pk1393)_upregulated
      WBPaper00049498:npr-1(ur89)_regulated_1
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00049954:BPS_upregulated
      WBPaper00050182:lmn-1(L535P)_upregulated
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051021:4-bromodiphenyl-ether_downregulated
      WBPaper00051265:F1_hrde-1(tm1200)_downregulated
      WBPaper00051265:F4_hrde-1(tm1200)_downregulated
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00051388:Glucose-diet_upregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00051498:zinc-reduction_upregulated
      WBPaper00051558:aging_regulated
      WBPaper00053020:sid-3(ok973)_upregulated
      WBPaper00053020:sta-1(ok587)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00054192:cold-shock_downregulated
      WBPaper00054410:set-26(tm2467)_downregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055013:hmg-3(bar24)_downregulated
      WBPaper00055013:spt-16(RNAi)_downregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055386:eat-2(ad465)_downregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055944:C.butyricum_vs_OP50_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00056039:ptl-1(ok621)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056169:rrf-3(pk1426)_upregulated_L1
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056446:hsb-1(cg116)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056586:kri-1(ok1251);mpk-2(ok219)_downregulated
      WBPaper00056617:adr-1_upregulated_L4_transcript
      WBPaper00056826:SGP_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
      WBPaper00057149:prgn-1(tm985)_downregulated
      WBPaper00057154:HeatShock_downregulated_miRNA-target
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057347:nhr-14(tm1473)_downreglated
      WBPaper00058711:skn-1(lax188)_upregulated
      WBPaper00058927:high-redox-state_upregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059231:alh-6(lax105)_L4_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059378:cec-4(ok3124);lmn-1(Y59C)_vs_lmn-1(Y59C)_upregulated
      WBPaper00059378:lmn-1(Y59C)_downregulated
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059735:glucose_upregulated_lpin-1(RNAi)
      WBPaper00059735:glucose_upregulated_N2
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059816:crh-1(n3315)_uprgulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060273:vrk-1(RNAi)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
      WBPaper00060445:ikb-1(nr2027)_downregulated_L4
      WBPaper00060445:nfki-1(cer1)_downregulated_L1
      WBPaper00060445:nfki-1(cer1)_downregulated_L4
      WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_downregulated_L4
      WBPaper00060526:plp-1(ok2155)_downregulated
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-extract_1h_regulated
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00060886:met-2(n4256)_upregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00060921:tdc-1(n3419)_downregulated
      WBPaper00060921:tph-1(mg280)_upregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:HB115_upregulated
      WBPaper00061007:M.braciatum_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061340:ADEsh
      WBPaper00061340:Excretory_duct_and_pore
      WBPaper00061340:F_U
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:hyp3
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:hyp7_AB_lineage
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061340:K_Kprime
      WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
      WBPaper00061340:P_cell
      WBPaper00061340:Seam_cell
      WBPaper00061340:T
      WBPaper00061340:Tail_hypodermis
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:mlt-9_22518-F33D4.6_14044
      WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
      WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated
      WBPaper00061651:AMso_enriched
      WBPaper00061653:alh-4(hj221)_downregulated
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062056:lin-37(n758)_downregulated
      WBPaper00062156:jmjd-1.2(zr1010)_upregulated
      WBPaper00062156:jmjd-5(zr1234)_downregulated_germline
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00062534:fat-P-80_downregulated
      WBPaper00062534:fat-P-80_downregulated_ech-6(RNAi)
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00062684:pathogen_upregulated_N2
      WBPaper00062715:blmp-1(s71)_upregulated
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064494:postdauer_upregulated_AWA
      WBPaper00064509:static-magnetic-field_downregulated
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00064999:miR-229-64-65-66_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day1_25C
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065225:nhr-42(tm1375)_upregulated_uninfected
      WBPaper00065315:mating_upregulated_Day2-7
      WBPaper00065315:mating_upregulated_Day6-7
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065392:Lb.delbrueckii_downregulated
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065841:1_0
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066005:RAGA-1_degradation_somatic_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_4_6
      cgc4489_group_23
      WBPaper00005124:cholesterol_10-9M_regulated
      WBPaper00005124:estrogen_10-5M_regulated
      WBPaper00025032:cluster_24
      WBPaper00025032:PAL-1_target_genes
      WBPaper00025099:MA_specific
      WBPaper00026629:L2_male_enriched
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00034739:N2lessDR1350
      WBPaper00034739:RIL17lessRIL14
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osm-11_regulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_G
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00038304:octr-1_regulated
      WBPaper00039866:ClassComp_daf-19_upregulated
      WBPaper00039866:SAM_daf-19_upregulated
      WBPaper00040185:nhr-23(RNAi)_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041002:HF_11d_0.2mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00041207:CE_dauer_down
      WBPaper00041609:hpl-1_hpl-2_upregulated
      WBPaper00041960:daf-16_fasting_upregulated
      WBPaper00041960:jun-1_fasting_upregulated
      WBPaper00041960:kgb-1_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042128:gei-8(ok1671)_downregulated
      WBPaper00042258:DA1877_downregulated_YoungAdult
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00046083:oga-1(ok1207)_OP50_downregulated
      WBPaper00046083:ogt-1(ok1474)_OP50_downregulated
      WBPaper00046083:pmk-1(km25)_OP50_downregulated
      WBPaper00046548:dafachronic-acid_upregulated
      WBPaper00046639:tyrosol_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00050767:Octopamine_induced
      WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      [cgc5767]:cluster_12
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(122_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:Cluster_B
    Interaction (79)
    WBProcess: WBbiopr:00000123
  Map_info: Map: II Position: 0.503783 Error: 5.6e-05
    Positive: Positive_clone: ZK1290 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00003717
    WBPaper00026629
    WBPaper00026841
    WBPaper00027263
    WBPaper00028754
    WBPaper00031588
    WBPaper00058696
    WBPaper00059378
    WBPaper00059816
    WBPaper00064105
    WBPaper00065331
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene