WormBase Tree Display for Gene: WBGene00003474

WBGene00003474 SMap: S_parent: Sequence: T08G5
  Identity: Version: 1
    Name: CGC_name: mtl-2 Person_evidence: WBPerson1414
      Sequence_name: T08G5.10
      Molecular_name: T08G5.10
        T08G5.10.1
        CE25109
      Other_name: met-II Accession_evidence: EMBL X53245
              D17365
        CELE_T08G5.10 Accession_evidence: NDB BX284605
      Public_name: mtl-2
    DB_info: Database: AceView gene 5O498
        WormQTL gene WBGene00003474
        WormFlux gene WBGene00003474
        NDB locus_tag CELE_T08G5.10
        NCBI gene 179899
        RefSeq protein NM_074081.9
        SwissProt UniProtAcc P17512
        UniProt_GCRP UniProtAcc P17512
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mtl
    Allele (15)
    Legacy_information: [C.elegansII] NMK. Encodes 63 aa metallothionein; accumulates after exposure to CdCl2. mtl-1:lacZ expressed in intestine after cadmium treatment or heat shock. [Freedman et al. 1993]
    Strain: WBStrain00005079
      WBStrain00005080
      WBStrain00005081
      WBStrain00005101
      WBStrain00040877
      WBStrain00035525
    RNASeq_FPKM (74)
    GO_annotation: 00039557
      00039558
      00106045
      00106046
      00106267
      00106268
    Ortholog: WBGene00027389 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
      WBGene00027390 Caenorhabditis briggsae From_analysis: OrthoMCL
            Inparanoid_8
            WormBase-Compara
      WBGene00151369 Caenorhabditis brenneri From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00271681 Caenorhabditis briggsae From_analysis: WormBase-Compara
      FL83_06429 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_020394 Caenorhabditis remanei From_analysis: WormBase-Compara
      chrV_pilon.g16404 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00057046 Caenorhabditis remanei From_analysis: WormBase-Compara
    Structured_description: Concise_description: mtl-2 encodes one of two C. elegans metallothioneins, small, cysteine-rich, metal-binding proteins; MTL-2 functions in metal detoxification and homeostasis and stress adaptation; in addition, mtl-2 plays a role in regulating growth and fertility; mtl-2 expression is induced in larval and adult intestinal cells following exposure to cadmium or heat shock; MTL-2 intestinal expression is dependent upon ELT-2, an intestine-specific GATA-type transcription factor; mtl-2 is downregulated by DAF-16 in daf-2 mutants. Paper_evidence: WBPaper00001688
            WBPaper00003700
            WBPaper00004299
            WBPaper00004381
            WBPaper00005295
            WBPaper00005976
            WBPaper00028866
          Curator_confirmed: WBPerson1843
          Date_last_updated: 07 May 2007 00:00:00
      Automated_description: Enables cadmium ion binding activity and zinc ion binding activity. Involved in response to cadmium ion and response to heat. Expressed in intestinal cell and intestine. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T08G5.10
    Corresponding_transcript: T08G5.10.1
    Other_sequence: CBC00932_1
      CBC01514_2
      FD517649.1
      CBC01514_1
      CJC01860_1
      CSC00487_1
      FD517704.1
    Associated_feature: WBsf653359
      WBsf919637
      WBsf919638
      WBsf982357
      WBsf982358
      WBsf234895
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr1380
      Expr1509
      Expr3079
      Expr1020789
      Expr1156496
      Expr2013808
      Expr2032048
    Drives_construct (15)
    Construct_product: WBCnstr00007972
      WBCnstr00007973
      WBCnstr00011119
      WBCnstr00036093
    Microarray_results (19)
    Expression_cluster: WBPaper00032031:DConiospora_downregulated_OligoArray_24h
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033444:BacteriaDiet_regulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:intestine_larva_SelectivelyEnriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038061:aldicarb_upregulated
      WBPaper00038118:aak-2(gt33)_downregulated
      WBPaper00038118:stress_downregulated_N2
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038168:lin-35_downregulated
      WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00040209:B.thuringiensis_downregulated_MY15
      WBPaper00040209:B.thuringiensis_downregulated_MY18
      WBPaper00040560:hpl-2_embryo_downregulated
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044030:nhr-8(hd117)_downregulated
      WBPaper00044037:eat-2_downregulated
      WBPaper00044316:CH3HgCl_0.75uM_downregulated
      WBPaper00044316:CH3HgCl_2.0uM_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044316:HgCl2_2.0uM_upregulated
      WBPaper00044316:HgCl2_7.5uM_upregulated
      WBPaper00044316:HgCl2_20uM_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045316:prg-1_downregulated_L2
      WBPaper00045316:prg-1_downregulated_L3
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00046128:ethanol_downregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046741:Garlic-Extract_downregulated_mRNA
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048423:LP133_LF21_upregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_upregulated
      WBPaper00049266:NaAsO2-Stress_regulated_N2
      WBPaper00049266:NaAsO2-Stress_regulated_trx-1(ok1449)
      WBPaper00049334:CE_intestine_enriched
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00049484:elt-2(RNAi)_downregulated_L1
      WBPaper00049484:elt-2(RNAi)_downregulated_L4
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00049954:BPS_upregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050225:flp-6(RNAi)_downregulated
      WBPaper00050234:lin-28(RNAi)_downregulated
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051039:intestine_enriched
      WBPaper00051137:N.parisii-virus_downregulated_N2
      WBPaper00051265:F4_morc-1(tm6048)_downregulated
      WBPaper00051388:Glucose-diet_downregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051498:zinc-reduction_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053402:his-3(RNAi)_downregulated
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_downregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053737:Anatase-TiO2-Nanoparticles_upregulated
      WBPaper00053782:daf-2(RNAi)_oocyte_downregulated
      WBPaper00053814:OP50_vs_PY79_upregulated_PY79
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054872:egl-9(sa307)_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056039:efa-6(tm3124)_upregulated
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056090:hpx-2(dg047)_upregulated_E.faecalis
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056284:ints-1(RNAi)_upregulated
      WBPaper00056284:ints-2(RNAi)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056731:human-amylin_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057265:metaformin_upregulated_OP50
      WBPaper00058665:graphene-oxide_downregulated_mRNA
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058725:sftb-1(cer39)_upregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_PA14
      WBPaper00058948:PA14_upregulated
      WBPaper00059334:sacy-1(depletion)_regulated
      WBPaper00059421:daf-1(m40)_downregulated
      WBPaper00059477:hlh-2(RNAi)_regulated
      WBPaper00059739:hira-1(gk835598)_downregulated_adult
      WBPaper00059739:hira-1(gk835598)_downregulated_L4
      WBPaper00059763:neuron_expressed
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_downregulated_CoCl2_6hr
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061007:M.braciatum_downregulated
      WBPaper00061007:X.citri_downregulated
      WBPaper00061045:Y56A3A.22(cck200)_upregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061424:Diet_MYb120_downregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061478:pie-1(ne4433)_upregulated
      WBPaper00061479:prg-1(tm872)_upregulated
      WBPaper00061527:R10H10.3-T21H3.1
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061651:Intestine_enriched
      WBPaper00061651:M4_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062167:mbl-1(tm1563)_downregulated
      WBPaper00062193:daf-16(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062305:P.brevicompactum_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062347:blmp-1(tm548)_downregulated
      WBPaper00062520:qui-1(db104)_upregulated
      WBPaper00062534:fat-P-80_downregulated
      WBPaper00062534:fat-P-80_downregulated_ech-6(RNAi)
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064532:pals-22(jy3)_downregulated
      WBPaper00064727:daf-2(e1370)_downregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065158:AFD_depleted
      WBPaper00065288:mdt-15(tm2182)_downregulated
      WBPaper00065749:Heat-Shock-With-Recovery_downregulated_N2
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day5
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065841:3_0
      WBPaper00065841:3_1
      WBPaper00065841:3_2
      WBPaper00065841:3_5
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066038:mip-1(how5)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066204:CdCl2_upregulated_mRNA
      WBPaper00066232:hsf-1(RNAi)_downregulated_WT
      cgc4386_cluster_1_3
      cgc4489_group_2
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026629:L2_male_enriched
      WBPaper00026980:intestine_enriched
      WBPaper00028564:CeMM_vs_NGM_upregulated
      WBPaper00028789:PA14_vs_OP50_downregulated_8hr
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031060:2-deoxy-D-glucose_upregulated
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00031850:mdt-15(RNAi)_downregulated
      WBPaper00032165:differentially_expressed_with_age_medoid_4
      WBPaper00034739:N2moreDR1350
      WBPaper00035479:daf-16(RNAi)_upregulated
      WBPaper00035873:osm-8_regulated
      WBPaper00036286:Pattern_I
      WBPaper00037113:DZN_16C_down-regulated
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00040184:hcf-1down_sir-2.1down_daf-2nc
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040426:CYE-1_CDK-2AF_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041002:HQ_3d_0.2mM_Down
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00044091:Bpseudomallei_regulated_qPCR-confirmed
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045374:Benzene_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053550:daf-19(m86)_upregulated_L1
      WBPaper00055899:2,4-Dinitroanisole_regulated
    Interaction (39)
    WBProcess: WBbiopr:00000039
      WBbiopr:00000050
      WBbiopr:00000053
      WBbiopr:00000096
  Map_info: Map: V Position: 6.07164 Error: 0.009738
    Positive: Positive_clone: CR#MT2
        T08G5 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4288
        4500
    Pseudo_map_position
  Reference: WBPaper00001688
    WBPaper00002326
    WBPaper00002660
    WBPaper00003210
    WBPaper00003700
    WBPaper00004255
    WBPaper00005295
    WBPaper00005312
    WBPaper00005976
    WBPaper00006437
    WBPaper00011056
    WBPaper00020783
    WBPaper00022556
    WBPaper00023053
    WBPaper00023447
    WBPaper00024190
    WBPaper00024351
    WBPaper00025370
    WBPaper00025433
    WBPaper00026592
    WBPaper00027264
    WBPaper00027309
    WBPaper00027584
    WBPaper00027642
    WBPaper00028564
    WBPaper00028782
    WBPaper00028866
    WBPaper00030811
    WBPaper00032518
    WBPaper00033210
    WBPaper00033444
    WBPaper00034499
    WBPaper00034661
    WBPaper00036001
    WBPaper00036389
    WBPaper00036743
    WBPaper00037044
    WBPaper00037835
    WBPaper00038506
    WBPaper00038729
    WBPaper00038942
    WBPaper00038996
    WBPaper00039992
    WBPaper00040044
    WBPaper00040519
    WBPaper00041036
    WBPaper00042179
    WBPaper00042606
    WBPaper00042865
    WBPaper00042867
    WBPaper00044127
    WBPaper00044243
    WBPaper00044641
    WBPaper00045040
    WBPaper00046211
    WBPaper00048380
    WBPaper00048459
    WBPaper00049204
    WBPaper00050950
    WBPaper00051639
    WBPaper00051907
    WBPaper00052350
    WBPaper00053286
    WBPaper00053737
    WBPaper00056297
    WBPaper00058783
    WBPaper00059429
    WBPaper00059551
    WBPaper00063411
    WBPaper00064255
    WBPaper00065088
    WBPaper00065134
    WBPaper00066294
    WBPaper00066337
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene