WormBase Tree Display for Gene: WBGene00001093

WBGene00001093 SMap: S_parent: Sequence: T12E12
  Identity: Version: 1
    Name: CGC_name: drp-1 Person_evidence: WBPerson733
      Sequence_name: T12E12.4
      Molecular_name: T12E12.4a
        T12E12.4a.1
        CE30172
        T12E12.4b
        CE30173
        T12E12.4a.2
        T12E12.4b.1
        T12E12.4b.2
      Other_name: CELE_T12E12.4 Accession_evidence: NDB BX284604
      Public_name: drp-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: drp
    Allele (45)
    Strain: WBStrain00005196
      WBStrain00007389
      WBStrain00007408
      WBStrain00007414
    RNASeq_FPKM (74)
    GO_annotation (30)
    Contained_in_operon: CEOP4168
    Ortholog (39)
    Paralog: WBGene00001134 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001130 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: drp-1 encodes a dynamin-related protein, orthologous to Dnm1p in S. cerevisiae and DRP1 in mammals, that is required for severing of the mitochondrial outer membrane during mitochondrial division. Paper_evidence: WBPaper00003790
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable GTP binding activity; GTPase activity; and microtubule binding activity. Involved in apoptotic mitochondrial changes; embryo development; and mitochondrial fission. Located in mitochondrion. Expressed in several structures, including germ line; non-striated muscle; preanal ganglion; rectal muscle; and somatic nervous system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; encephalopathy due to defective mitochondrial and peroxisomal fission 1; optic atrophy 5; and pulmonary fibrosis. Is an ortholog of human DNM1L (dynamin 1 like). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:14330 Homo sapiens Paper_evidence: WBPaper00057005
          Curator_confirmed: WBPerson324
          Date_last_updated: 20 Feb 2020 00:00:00
    Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2973)
      DOID:0070347 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2973)
      DOID:0111438 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2973)
      DOID:3770 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2973)
  Models_disease_asserted: WBDOannot00000741
  Molecular_info: Corresponding_CDS: T12E12.4a
      T12E12.4b
    Corresponding_transcript: T12E12.4a.1
      T12E12.4a.2
      T12E12.4b.1
      T12E12.4b.2
    Other_sequence (72)
    Associated_feature: WBsf655022
      WBsf660150
      WBsf981759
      WBsf996535
      WBsf228316
      WBsf228317
      WBsf228318
  Experimental_info: RNAi_result (36)
    Expr_pattern: Expr543
      Expr11473
      Expr12437
      Expr1017306
      Expr1030697
      Expr1156803
      Expr2011094
      Expr2029330
    Drives_construct: WBCnstr00012431
      WBCnstr00037085
    Construct_product: WBCnstr00005418
      WBCnstr00005420
      WBCnstr00009299
      WBCnstr00012431
      WBCnstr00019040
      WBCnstr00037085
    Antibody: WBAntibody00001689
    Microarray_results (33)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00035073:mitochondria_protein
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049159:Microwave_upregulated_adult
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00049954:BPS_downregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050698:DEP-1_interacting
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:gut-microbiota_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_upregulated_protein
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
      WBPaper00060084:cco-1(RNAi)_upregulated_N2
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(et18)_upregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:OLQ
      WBPaper00061340:OLQ_parent
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:hrdl-1_3731-lst-4_2238
      WBPaper00061527:lst-4_22151-F46F11.6_12556
      WBPaper00061902:CAMT-1_interacting
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064201:SNA-3_interacting
      WBPaper00064315:mes-4(bn73)_downregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_1
      WBPaper00005124:testosterone_10-9M_regulated
      WBPaper00025032:cluster_4
      WBPaper00025032:cluster_76
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031832:slr-2_regulated
      WBPaper00034739:N2moreDR1350
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Cadmium_regulated
      WBPaper00037695:WC_5-day
      WBPaper00038060:SUMO-1_upregulated
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00038427:lin-54_germline_changed
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_3d_0.2mM_Down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00042234:xpa-1_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00049538:atfs-1(et18)_upregulated
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_9
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(53_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:Cluster_F
      [cgc6390]:oogenesis-enriched
    Interaction (114)
  Map_info: Map: IV Position: 1.82105 Error: 0.005501
    Positive: Positive_clone: T12E12 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00003790
    WBPaper00004211
    WBPaper00005928
    WBPaper00017000
    WBPaper00017049
    WBPaper00017548
    WBPaper00017869
    WBPaper00018470
    WBPaper00018471
    WBPaper00023353
    WBPaper00024031
    WBPaper00024200
    WBPaper00027283
    WBPaper00027647
    WBPaper00031376
    WBPaper00031851
    WBPaper00032123
    WBPaper00032231
    WBPaper00032387
    WBPaper00032740
    WBPaper00033026
    WBPaper00033637
    WBPaper00033678
    WBPaper00035054
    WBPaper00035144
    WBPaper00036249
    WBPaper00037283
    WBPaper00038057
    WBPaper00038293
    WBPaper00038491
    WBPaper00039103
    WBPaper00039881
    WBPaper00040243
    WBPaper00040433
    WBPaper00041209
    WBPaper00042228
    WBPaper00042543
    WBPaper00042756
    WBPaper00043145
    WBPaper00043233
    WBPaper00043728
    WBPaper00043942
    WBPaper00044205
    WBPaper00045076
    WBPaper00045696
    WBPaper00045775
    WBPaper00046671
    WBPaper00046973
    WBPaper00047030
    WBPaper00047547
    WBPaper00047736
    WBPaper00047992
    WBPaper00048226
    WBPaper00048254
    WBPaper00048474
    WBPaper00050610
    WBPaper00051852
    WBPaper00054455
    WBPaper00054478
    WBPaper00054980
    WBPaper00055090
    WBPaper00055144
    WBPaper00056369
    WBPaper00056678
    WBPaper00056988
    WBPaper00057005
    WBPaper00057196
    WBPaper00057476
    WBPaper00057708
    WBPaper00057916
    WBPaper00057931
    WBPaper00058465
    WBPaper00058472
    WBPaper00059531
    WBPaper00059545
    WBPaper00059578
    WBPaper00059627
    WBPaper00059895
    WBPaper00060398
    WBPaper00060507
    WBPaper00061190
    WBPaper00061409
    WBPaper00061852
    WBPaper00061891
    WBPaper00062017
    WBPaper00063171
    WBPaper00063897
    WBPaper00064317
    WBPaper00064733
    WBPaper00064979
    WBPaper00065115
    WBPaper00065243
    WBPaper00065666
  Remark: Sequence connection from [Labrousse AM, van der Bliek AM]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene