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WormBase Tree Display for Gene: WBGene00012354

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Name Class

WBGene00012354SMapS_parentSequenceW09C5
IdentityVersion2
NameCGC_namecox-4Person_evidenceWBPerson117
WBPerson7169
Sequence_nameW09C5.8
Molecular_nameW09C5.8
W09C5.8.1
CE20171
Other_nameCELE_W09C5.8Accession_evidenceNDBBX284601
Public_namecox-4
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:53WBPerson1971EventImportedInitial conversion from CDS class of WS125
205 Sep 2017 13:25:30WBPerson2970Name_changeCGC_namecox-4
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcox
Allele (24)
StrainWBStrain00037231
WBStrain00022511
WBStrain00047268
RNASeq_FPKM (74)
GO_annotation00099906
00099907
00099908
00099909
00099910
00099911
00099912
00099913
00119507
00119508
Ortholog (44)
Structured_descriptionConcise_descriptionW09C5.8 encodes the C. elegans ortholog of the cytochrome c oxidase (COX) subunit IV (COX IV); loss of W09C5.8 activity via RNAi results in a shortened life span, reduced fertility, and defects in mitochondrial respiratory chain function.Paper_evidenceWBPaper00032427
Curator_confirmedWBPerson1843
Date_last_updated08 Nov 2010 00:00:00
Automated_descriptionInvolved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial respiratory chain complex IV. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Is an ortholog of human COX4I1 (cytochrome c oxidase subunit 4I1) and COX4I2 (cytochrome c oxidase subunit 4I2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0070501Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2265)
Molecular_infoCorresponding_CDSW09C5.8
Corresponding_transcriptW09C5.8.1
Other_sequence (131)
Associated_featureWBsf649714
WBsf655327
WBsf220533
WBsf220534
WBsf220535
Experimental_infoRNAi_resultWBRNAi00026527Inferred_automaticallyRNAi_primary
WBRNAi00105963Inferred_automaticallyRNAi_primary
WBRNAi00112922Inferred_automaticallyRNAi_primary
WBRNAi00110919Inferred_automaticallyRNAi_primary
WBRNAi00004457Inferred_automaticallyRNAi_primary
WBRNAi00113360Inferred_automaticallyRNAi_primary
WBRNAi00078401Inferred_automaticallyRNAi_primary
WBRNAi00055032Inferred_automaticallyRNAi_primary
WBRNAi00112802Inferred_automaticallyRNAi_primary
WBRNAi00084375Inferred_automaticallyRNAi_primary
WBRNAi00026526Inferred_automaticallyRNAi_primary
WBRNAi00076750Inferred_automaticallyRNAi_primary
WBRNAi00065280Inferred_automaticallyRNAi_primary
WBRNAi00112862Inferred_automaticallyRNAi_primary
WBRNAi00078402Inferred_automaticallyRNAi_primary
WBRNAi00106234Inferred_automaticallyRNAi_primary
WBRNAi00116756Inferred_automaticallyRNAi_primary
WBRNAi00022851Inferred_automaticallyRNAi_primary
WBRNAi00095762Inferred_automaticallyRNAi_primary
WBRNAi00036402Inferred_automaticallyRNAi_primary
WBRNAi00106002Inferred_automaticallyRNAi_primary
Expr_patternExpr1028081
Expr1035471
Expr1158573
Expr2006884
Expr2025111
Drives_constructWBCnstr00029984
Construct_productWBCnstr00029984
Microarray_results (23)
Expression_clusterWBPaper00005700:secreted_protein
WBPaper00028451:Low_abundance_spermatogenesis_enriched
WBPaper00032528:L3_enriched
WBPaper00033065:clk-1(qm30)_upregulated
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00035073:mitochondria_protein
WBPaper00037047:aging_accelerated_insoluble_protein
WBPaper00037047:insoluble_protein
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038213:E.coli(LF82)_72h_upregulated
WBPaper00038289:oocyte_protein
WBPaper00040221:DAF-12_target_ALF4
WBPaper00040965:lipid-droplet_associated_protein
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00044746:aging_downregulated_HeatShock
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049498:npr-1(ur89)_regulated_3
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
WBPaper00050182:lmn-1(L535P)_downregulated
WBPaper00050344:ASER-neuron_enriched
WBPaper00050344:PLM-neuron_enriched
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050698:DEP-1_interacting
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051555:atm-1(gk186)_regulated_protein
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053295:lin-22(ot269)_downregulated
WBPaper00053388:dauer_regulated_Cluster6
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055648:germline_expressed
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056501:P.aeruginosa_upregulated_mitochondria-protein
WBPaper00056900:PID-3_interacting
WBPaper00057288:Cold_downregulated_protein
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059895:wounding_downregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060951:mrpl-2(osa3)_upregulated
WBPaper00061341:28C_48h_downregulated
WBPaper00061377:MYRF-1_interacting
WBPaper00061377:MYRF-2_interacting
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061527:F45H10.2-R53.4_21676
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062498:PPM-1.D_interacting
WBPaper00062554:MAGU-2_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064055:trl-1(cas1077)_downregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064201:SNA-3_interacting
WBPaper00064315:mes-4(bn73)_downregulated_EGCs
WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
WBPaper00064992:heat-shock_upregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065149:lin-52(n771)_downregulated
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065975:P-body_vs_oocyte_depleted
cgc4386_cluster_1_5
cgc4489_group_20
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026952:class_A
WBPaper00026980:intestine_enriched
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_developing
WBPaper00040858:eQTL_regulated_juvenile
WBPaper00040858:eQTL_regulated_old
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00044091:Bpseudomallei_repressed_12h
[cgc5767]:expression_class_M
[cgc5767]:expression_class_SM
Interaction (76)
Map_infoMapIPosition21.6359
PositivePositive_cloneW09C5Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (15)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene