WormBase Tree Display for Gene: WBGene00006059

WBGene00006059 SMap: S_parent: Sequence: F54C9
  Identity: Version: 1
    Name: CGC_name: stc-1
      Sequence_name: F54C9.2
      Molecular_name: F54C9.2
        F54C9.2.1
        CE32895
      Other_name: CELE_F54C9.2 Accession_evidence: NDB BX284602
      Public_name: stc-1
    DB_info: Database: AceView gene 2I854
        WormQTL gene WBGene00006059
        WormFlux gene WBGene00006059
        NDB locus_tag CELE_F54C9.2
        Panther gene CAEEL|WormBase=WBGene00006059|UniProtKB=Q20752
          family PTHR19375
        NCBI gene 174368
        RefSeq protein NM_063407.6
        TREEFAM TREEFAM_ID TF105047
        TrEMBL UniProtAcc Q20752
        UniProt_GCRP UniProtAcc Q20752
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:39 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: stc
    Allele (37)
    Strain: WBStrain00003191
      WBStrain00037244
    RNASeq_FPKM (74)
    GO_annotation: 00068998
      00068999
      00069000
      00069001
      00069002
      00069003
      00069004
      00105642
      00113932
      00113933
    Contained_in_operon: CEOP2732
    Ortholog (38)
    Paralog (11)
    Structured_description: Concise_description: stc-1 encodes an ATPase that is similar to the vertebrate HSPA13/STCH proteins that are members of the heat shock protein 70 family; by homology, STC-1 is predicted to function as an ER chaperone, and loss of stc-1 activity results in induction of an hsp-4::gfp transgene and increased aggregation of a heterologously expressed mutant human SOD1 protein in C. elegans neurons. Paper_evidence: WBPaper00025202
            WBPaper00034765
          Curator_confirmed: WBPerson1843
          Date_last_updated: 19 Jun 2012 00:00:00
      Automated_description: Predicted to enable ATP binding activity and ATP-dependent protein folding chaperone. Involved in IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum. Is an ortholog of human HSPA13 (heat shock protein family A (Hsp70) member 13). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F54C9.2
    Corresponding_CDS_history: F54C9.2:wp92
    Corresponding_transcript: F54C9.2.1
    Other_sequence (60)
    Associated_feature: WBsf650337
      WBsf650338
      WBsf223515
      WBsf223516
  Experimental_info: RNAi_result: WBRNAi00106312 Inferred_automatically: RNAi_primary
      WBRNAi00071183 Inferred_automatically: RNAi_primary
      WBRNAi00076473 Inferred_automatically: RNAi_primary
      WBRNAi00032763 Inferred_automatically: RNAi_primary
      WBRNAi00113533 Inferred_automatically: RNAi_primary
      WBRNAi00025620 Inferred_automatically: RNAi_primary
      WBRNAi00065369 Inferred_automatically: RNAi_primary
      WBRNAi00008848 Inferred_automatically: RNAi_primary
      WBRNAi00081621 Inferred_automatically: RNAi_primary
      WBRNAi00108156 Inferred_automatically: RNAi_primary
      WBRNAi00048270 Inferred_automatically: RNAi_primary
      WBRNAi00066899 Inferred_automatically: RNAi_primary
      WBRNAi00000918 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram85
      Chronogram161
      Expr6171
      Expr1028129
      Expr1032535
      Expr1152072
      Expr2016955
      Expr2035103
    Drives_construct: WBCnstr00002043
      WBCnstr00003666
      WBCnstr00034567
    Construct_product: WBCnstr00016467
      WBCnstr00034567
    Microarray_results (18)
    Expression_cluster: WBPaper00030922:glycosylated_protein
      WBPaper00032425:up_in_rde-4
      WBPaper00037950:all-neurons_embryo_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Spermatogenic
      WBPaper00045774:clk-1_downregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00054410:set-26(tm2467)_downregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055648:germline_expressed
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059328:mrps-5(RNAi)_downregulated_protein
      WBPaper00059987:Wounding_upregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00061274:microgravity_upregulated
      WBPaper00061340:g1P
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061527:C18E9.4-T27E9.2
      WBPaper00061651:VB01_enriched
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062520:qui-1(db104)_upregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064716:paraquat_upregulated
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      cgc4489_group_8
      WBPaper00006465:II_ethanol_late_induction
      WBPaper00025032:cluster_193
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_3
      WBPaper00032948:FedUp
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (41)
  Map_info: Map: II Position: 0.816802 Error: 0.000353
    Positive: Positive_clone: F54C9 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00006465
    WBPaper00024340
    WBPaper00025183
    WBPaper00025202
    WBPaper00034765
    WBPaper00038491
    WBPaper00043951
    WBPaper00051015
    WBPaper00055090
  Remark: Sequence connection from [Otterson GA, Kaye FJ, Johnstone IL], [020809 krb]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene