| WBGene00015547 | SMap | S_parent | Sequence | C06G1 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | ain-1 | Person_evidence | WBPerson237 |
| | | Sequence_name | C06G1.4 |
| | | Molecular_name | C06G1.4 |
| | | | C06G1.4.1 |
| | | | CE03967 |
| | | Other_name | CELE_C06G1.4 | Accession_evidence | NDB | BX284606 |
| | | Public_name | ain-1 |
| | DB_info | Database | AceView | gene | XR231 |
| | | | WormQTL | gene | WBGene00015547 |
| | | | WormFlux | gene | WBGene00015547 |
| | | | NDB | locus_tag | CELE_C06G1.4 |
| | | | NCBI | gene | 181719 |
| | | | RefSeq | protein | NM_078286.9 |
| | | | TREEFAM | TREEFAM_ID | TF350152 |
| | | | TrEMBL | UniProtAcc | Q17740 |
| | | | UniProt_GCRP | UniProtAcc | Q17740 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 28 May 2004 13:30:56 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 |
| | | | 2 | 09 Sep 2005 11:28:41 | WBPerson2970 | Name_change | CGC_name | ain-1 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | ain |
| | Allele (55) |
| | Strain | WBStrain00026530 |
| | | WBStrain00026534 |
| | | WBStrain00034970 |
| | | WBStrain00054873 |
| | | WBStrain00054872 |
| | RNASeq_FPKM (74) |
| | GO_annotation (22) |
| | Ortholog | WBGene00063227 | Caenorhabditis remanei | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00036310 | Caenorhabditis briggsae | From_analysis | Hillier-set |
| | | | | | OrthoMCL |
| | | | | | OMA |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00126101 | Caenorhabditis japonica | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00192902 | Caenorhabditis brenneri | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00222281 | Brugia malayi | From_analysis | WormBase-Compara |
| | | WBGene00228386 | Brugia malayi | From_analysis | WormBase-Compara |
| | | CBOVI.g3989 | Caenorhabditis bovis | From_analysis | WormBase-Compara |
| | | CSP26.g9773 | Caenorhabditis zanzibari | From_analysis | WormBase-Compara |
| | | CSP28.g16208 | Caenorhabditis panamensis | From_analysis | WormBase-Compara |
| | | CSP29.g4640 | Caenorhabditis becei | From_analysis | WormBase-Compara |
| | | CSP31.g24539 | Caenorhabditis uteleia | From_analysis | WormBase-Compara |
| | | CSP32.g13816 | Caenorhabditis sulstoni | From_analysis | WormBase-Compara |
| | | CSP38.g10450 | Caenorhabditis quiockensis | From_analysis | WormBase-Compara |
| | | CSP39.g13387 | Caenorhabditis waitukubuli | From_analysis | WormBase-Compara |
| | | CSP40.g10939 | Caenorhabditis tribulationis | From_analysis | WormBase-Compara |
| | | Cang_2012_03_13_00664.g13275 | Caenorhabditis angaria | From_analysis | WormBase-Compara |
| | | Cni-ain-1 | Caenorhabditis nigoni | From_analysis | WormBase-Compara |
| | | Csp11.Scaffold629.g13319 | Caenorhabditis tropicalis | From_analysis | WormBase-Compara |
| | | Csp5_scaffold_00001.g69 | Caenorhabditis sinica | From_analysis | WormBase-Compara |
| | | FL83_02352 | Caenorhabditis latens | From_analysis | WormBase-Compara |
| | | GCK72_023193 | Caenorhabditis remanei | From_analysis | WormBase-Compara |
| | | OTIPU.nOt.2.0.1.g01820 | Oscheius tipulae | From_analysis | WormBase-Compara |
| | | Sp34_X0044100 | Caenorhabditis inopinata | From_analysis | WormBase-Compara |
| | | chrX_pilon.g20900 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00239324 | Onchocerca volvulus | From_analysis | WormBase-Compara |
| | | WBGene00111963 | Pristionchus pacificus | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | ain-1 encodes an unfamiliar protein synergistically required, withLIN-31, for the normal timing of vulval differentiation, independentlyof LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1;AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) inseveral tissues, including vulval precursor cells and neurons; AIN-1coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro,and does not require DNA or RNA for its binding; in vivo, AIN-1 targetsALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2; AIN-1 islikely to be a RISC component, since anti-AIN-1 antibodies precipitate29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77,and mir-239a; ain-1(ku322) mutants are essentially wild-type, except forsporadically gapped alae and excess seam cell nuclei arising fromretarded seam cell fusion; more prominently, ain-1(ku322) suppresses themultivulva phenotype of lin-31(n1053) mutations, while stronglyenhancing lin-31(n1053)'s egg-laying defect; the cellular basis oflin-31(n1053);ain-1(ku322) phenotypes is a delay in vulval developmentin L4 larvae not seen with either mutation alone; ain-1(ku322) has noeffect on let-60(n1046) or lin-3(e1275) mutations; ain-1(ku322)suppresses the precocious vulval development of lin-14(RNAi), lin-28mutants, and hbl-1(RNAi); alg-1 or alg-1 ain-1 mutant alae resembleain-1 alae, indicating that ALG-1 and AIN-1 act in a common geneticpathway; AIN-1 is homologous to Brugia malayi 14748.m00068,14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2;AIN-1 and its nematode homologs have weak similarity to human TNRC6A(GW182; OMIM:610739) and Drosophila GAWKY. | Paper_evidence | WBPaper00026707 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 07 May 2007 00:00:00 |
| | | Automated_description | Involved in several processes, including embryo development; negative regulation of gene expression; and regulation of developmental process. Located in P-body. Expressed widely. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C06G1.4 |
| | Corresponding_CDS_history | C06G1.4:wp95 |
| | | C06G1.4:wp99 |
| | Corresponding_transcript | C06G1.4.1 |
| | Other_sequence (15) |
| | Associated_feature (15) |
| Experimental_info | RNAi_result (16) |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00009448 |
| | | WBCnstr00011571 |
| | | WBCnstr00014500 |
| | | WBCnstr00017585 |
| | | WBCnstr00018660 |
| | | WBCnstr00019818 |
| | | WBCnstr00028761 |
| | | WBCnstr00039524 |
| | Construct_product | WBCnstr00011571 |
| | | WBCnstr00018660 |
| | | WBCnstr00019818 |
| | | WBCnstr00028761 |
| | | WBCnstr00039524 |
| | Regulate_expr_cluster | WBPaper00031252:AIN-1_IP_enriched |
| | Antibody | WBAntibody00001341 |
| | | WBAntibody00002435 |
| | | WBAntibody00002673 |
| | | WBAntibody00002711 |
| | Microarray_results (24) |
| | Expression_cluster | WBPaper00024505:pharyngeal_enriched |
| | | WBPaper00028451:Oogenic_protein |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00041071:spe-44_upregulated |
| | | WBPaper00044260:1-methylnicotinamide_downregulated |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049018:SWSN-2.2_interacting |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00049954:BPS_upregulated |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:cytoplasm_specific |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051352:Long-Term-Association-Memory_upregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053814:15C_downregulated_OP50 |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056073:NHR-86_interacting_promoter |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056218:daf-16(mu86)_upregulated_Day7 |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059224:tph-1(mg280)_upregulated |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061466:nath-10(icb102)_downregulated |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061527:pkn-1_20439-tbc-12_11015 |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064080:let-7_miRNA_interacting |
| | | WBPaper00064080:miR-2_miRNA_interacting |
| | | WBPaper00064080:miR-58_miRNA_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064130:Beta-Amyloid_upregulated_protein |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | cgc4386_cluster_6_3 |
| | | cgc4489_group_8 |
| | | WBPaper00025032:cluster_2 |
| | | WBPaper00025032:cluster_12 |
| | | WBPaper00026929:Resveratrol_regulated_N2 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041960:N2_fasting_upregulated_9hto12h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:cluster_2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(83_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:Cluster_A |
| | Interaction (458) |
| Map_info | Map | X | Position | 24.0566 | Error | 0.000506 |
| | Positive | Positive_clone | C06G1 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (40) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
