WormBase Tree Display for Gene: WBGene00004726

WBGene00004726 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F10E9
  Identity: Version: 1
    Name: CGC_name: sas-4 Person_evidence: WBPerson561
      Sequence_name: F10E9.8
      Molecular_name: F10E9.8
        F10E9.8.1
        CE29756
      Other_name: dcd-1
        CELE_F10E9.8 Accession_evidence: NDB BX284603
      Public_name: sas-4
    DB_info: Database: AceView gene 3J404
        WormQTL gene WBGene00004726
        WormFlux gene WBGene00004726
        NDB locus_tag CELE_F10E9.8
        NCBI gene 176172
        RefSeq protein NM_066427.8
        SwissProt UniProtAcc P34402
        UniProt_GCRP UniProtAcc P34402
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sas
    Allele (44)
    RNASeq_FPKM (74)
    GO_annotation: 00042155
      00042156
      00042157
      00042158
      00042159
      00042160
      00042161
      00042162
    Contained_in_operon: CEOP3504
    Ortholog: WBGene00042597 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00159945 Caenorhabditis brenneri From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00085213 Caenorhabditis remanei From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00126755 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      CBOVI.g6102 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g1194 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g19122 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g16390 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP28.g2281 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP31.g22341 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g2595 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g6586 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP40.g657 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00118.g4861 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-sas-4 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold561.g3908 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00089.g3939 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_22029 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_009806 Caenorhabditis remanei From_analysis: WormBase-Compara
      Sp34_30235910 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g8362 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: sas-4 encodes a predicted coiled-coil protein and centriole component recruited to the centrosome once per cell cycle at the time of organelle duplication and is required for centriole duplication and spindle assembly, levels dictate centrosome size, and also affects germ cell proliferation and locomotion; colocalizes with gamma-tubulin to centrosomes both in sperm and in the syncitial part of the gonad. Paper_evidence: WBPaper00005739
            WBPaper00005765
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Involved in centriole replication and maintenance of protein location. Located in centriole. Expressed in gonad; intestinal cell; and sperm. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F10E9.8
    Corresponding_transcript: F10E9.8.1
    Other_sequence: CRC03242_1
      CBC04687_1
    Associated_feature: WBsf993303
      WBsf993304
      WBsf1015391
      WBsf227106
  Experimental_info: RNAi_result (16)
    Expr_pattern (13)
    Drives_construct (4)
    Construct_product (13)
    Antibody: WBAntibody00000606
      WBAntibody00000608
      WBAntibody00000818
      WBAntibody00001884
      WBAntibody00001979
      WBAntibody00003028
    Microarray_results (20)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045521:Gender_Neutral
      WBPaper00047132:skn-1(RNAi)_downregulated_glp-1(ts)-dependent
      WBPaper00048988:neuron_expressed
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051461:pig-1(gm344)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055648:germline_expressed
      WBPaper00055827:daf-2(e1370)_downregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061340:AMso
      WBPaper00061340:B
      WBPaper00061340:I2_grandparent
      WBPaper00061340:M1_parent
      WBPaper00061340:Neuroblast_ADF_AWB
      WBPaper00061340:Neuroblast_IL1_IL2
      WBPaper00061340:Parent_of_MI_pm1DR
      WBPaper00061340:PLM_ALN_great_grandparent
      WBPaper00061340:rect_D
      WBPaper00061340:Y
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061527:kle-2_4298-vrk-1
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_6_4
      cgc4489_group_2
      WBPaper00005475:Aging-regulated
      WBPaper00025032:cluster_52
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00029437:dcr-1_downregulated
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00037147:heatshock_upregulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040823:alg-1(gk214)_downregulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00056330:mrps-5(RNAi)_downregulated
      [cgc5767]:cluster_2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:Cluster_F
      [cgc6390]:oogenesis-enriched
    Interaction (38)
  Map_info: Map: III Position: -0.339903 Error: 0.002682
    Positive: Positive_clone: F10E9 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (52)
  Remark: Sequence connection from [Gonczy P]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene