| WBGene00001680 | SMap | S_parent | Sequence | F52A8 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | gpb-2 | Person_evidence | WBPerson625 |
| | | Sequence_name | F52A8.2 |
| | | Molecular_name | F52A8.2a |
| | | | F52A8.2a.1 |
| | | | CE50400 |
| | | | F52A8.2b |
| | | Other_name | eat-11 |
| | | | gbp-2 | Paper_evidence | WBPaper00033094 |
| | | | CELE_F52A8.2 | Accession_evidence | NDB | BX284601 |
| | | Public_name | gpb-2 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 15 Dec 2010 15:28:40 | WBPerson2970 | Event | Acquires_merge | WBGene00001524 |
| | | | | | | Name_change | Other_name | gbp-2 |
| | | Acquires_merge | WBGene00001524 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | gpb |
| | Allele (47) |
| | Legacy_information | [Leon Avery] Weak Eat: slippery corpus. Slightly long. Movement slightly loopy (i.e. bends are deeper than normal). Hypersensitive to arecoline: will not grown at concentrations >= 1 mM. |
| | | See also ad541 |
| | | [C.elegansII] ad541 : weak Eat: slippery corpus. Slightly long. Movement slightly loopy (i.e. bends are deeper than normal). Hypersensitive to arecoline (cholinergic agonist): will not grown at concentrations >= 1 mM. Synthetic lethal with eat-6; suppressed by egl-30(gf), exp-2(gf). NA1. [Avery 1993; DA; JT] |
| | | [M Robatzek] eat-11 is allelic to gpb-2 (Robatzek et al. Current Biology 2001, 11:288-293) |
| | Strain | WBStrain00028988 |
| | | WBStrain00029004 |
| | | WBStrain00022804 |
| | | WBStrain00028986 |
| | | WBStrain00037676 |
| | | WBStrain00005480 |
| | | WBStrain00005517 |
| | RNASeq_FPKM (74) |
| | GO_annotation (20) |
| | Ortholog (39) |
| | Paralog | WBGene00001679 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | gpb-2 encodes an ortholog of Gbeta(5), that is dispensable for viability, but required for normal egg-laying, locomotion, and pharyngeal pumping; GBP-2 may regulate the interaction between the GOA-1 and EGL-30 signaling pathways based on genetic analysis; gpb-2 is expressed throughout development in the nervous system and in muscle, and expression is dependent upon expression of both EAT-16 and EGL-10. | Paper_evidence | WBPaper00002466 |
| | | | | | WBPaper00004406 |
| | | | | | WBPaper00004687 |
| | | | | | WBPaper00004713 |
| | | | | | WBPaper00004714 |
| | | | | | WBPaper00014715 |
| | | | | | WBPaper00015075 |
| | | | | | WBPaper00015719 |
| | | | | | WBPaper00016788 |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to enable signaling receptor complex adaptor activity. Involved in several processes, including cellular response to organonitrogen compound; regulation of egg-laying behavior; and regulation of pharyngeal pumping. Located in neuronal cell body. Expressed in body wall musculature; neurons; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in intellectual developmental disorder with cardiac arrhythmia. Is an ortholog of human GNB5 (G protein subunit beta 5). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0081008 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4401) |
| Molecular_info | Corresponding_CDS | F52A8.2a |
| | Corresponding_CDS_history | F52A8.2:wp246 |
| | Corresponding_transcript | F52A8.2b |
| | | F52A8.2a.1 |
| | Other_sequence (82) |
| | Associated_feature | WBsf984145 |
| | | WBsf984146 |
| | | WBsf1010061 |
| | | WBsf1010062 |
| | | WBsf219742 |
| | | WBsf219743 |
| | | WBsf219744 |
| Experimental_info | RNAi_result | WBRNAi00047906 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089830 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00032572 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00116830 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00063514 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090194 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089876 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090035 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1344 |
| | | Expr1360 |
| | | Expr1020669 |
| | | Expr1031001 |
| | | Expr1151735 |
| | | Expr2012200 |
| | | Expr2030436 |
| | Drives_construct | WBCnstr00000572 |
| | | WBCnstr00001696 |
| | | WBCnstr00001704 |
| | | WBCnstr00022812 |
| | | WBCnstr00036776 |
| | Construct_product | WBCnstr00001696 |
| | | WBCnstr00036776 |
| | Antibody | WBAntibody00000370 |
| | Microarray_results | SMD_F52A8.2 |
| | | 193647_s_at |
| | | A_12_P108980 |
| | | A_12_P149040 |
| | | Aff_F52A8.2 |
| | | GPL13394_WBGene00001680 |
| | | GPL13914_F52A8.2 |
| | | GPL14144_F52A8.2_472-531_0.918_7_C |
| | | GPL14144_F52A8.2_687-746_0.933_3_B |
| | | GPL14144_F52A8.2_741-800_0.939_1_A |
| | | GPL19516_CGZ0022872 |
| | | GPL21109_F52A8.2 |
| | | GPL3518_CE17845 |
| | | GPL8304_CE_WBGene00001680_A |
| | | GPL8673_F52A8_2P00286 |
| | | GPL8673_F52A8_2P00654 |
| | | GPL8673_F52A8_2P00921 |
| | | GPL9450_F52A8.2 |
| | | cea2.c.03792 |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00038438:Harposporium_24hr_upregulated_RNAseq |
| | | WBPaper00044037:eat-2_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045974:NSM_enriched_totalRNA_tiling |
| | | WBPaper00046121:mesoderm_unique |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049290:rsks-1(sv31)_upregulated |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050094:mes-2(bn11)_upregulated |
| | | WBPaper00050094:mes-6(bn66)_upregulated |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051461:pig-1(gm344)_downregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00053810:sod-2(ok1030)_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056855:his-72(uge40)_upregulated |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:PVR |
| | | WBPaper00061466:nath-10(icb102)_downregulated |
| | | WBPaper00061479:hda-1(ne4748)_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064494:postdauer_downregulated_AWA |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064992:Capsaicin_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4386_cluster_6_5 |
| | | cgc4489_group_8 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00032948:StarveUp2 |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00036286:Pattern_I |
| | | WBPaper00037695:LD_3-day |
| | | WBPaper00040963:TA300_up |
| | | WBPaper00041002:HF_3d_0.2mM_Up |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5976]:class_1 |
| | Interaction (64) |
| Map_info | Map | I | Position | 1.91015 | Error | 0.005018 |
| | Well_ordered |
| | Positive | Positive_clone | F52A8 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | R02H7 |
| | Negative | Negative_clone | F07A5 |
| | Mapping_data | 2_point | 6193 |
| | | Multi_point | 2456 |
| | | | 2457 |
| | | | 2458 |
| | | | 2459 |
| | | | 2460 |
| | | | 3034 |
| | | | 3946 |
| | | | 3947 |
| | | | 4489 |
| | | | 4710 |
| | | Pos_neg_data | 7086 |
| | | | 7087 |
| | | | 7088 |
| Reference (70) |
| Remark | Interacting_genes '[Leon Avery] eat-6: Lethal or subviable in double mutants with eat-6. |
| | Interacting_genes '[Leon Avery] egl-30: Suppressed by egl-30(gf) mutations. |
| Method | Gene |
