che-2 encodes a protein that contains G-protein beta-like WD-40 repeats that affects chemotaxis, dauer formation, and longevity; expressed in the cilia of most ciliated sensory neurons, some head neurons, and male tail rays.
Involved in several processes, including dauer larval development; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of locomotion involved in locomotory behavior. Located in ciliary basal body and non-motile cilium. Expressed in neurons. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 2. Is an ortholog of human IFT80 (intraflagellar transport 80).