rme-2 encodes a member of the low-density lipoprotein (LDL) receptor superfamily; RME-2 functions as the C. elegans yolk receptor whose activity is required for yolk uptake during oogenesis; RME-2 is expressed in developing oocytes where it localizes at or near the cell surface.
Enables low-density lipoprotein particle receptor activity. Involved in embryo development; oocyte development; and ovulation. Located in endosome membrane and plasma membrane. Expressed in germ cell; germ line; and gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; female reproductive organ cancer (multiple); hepatobiliary system cancer (multiple); and high grade glioma (multiple). Is an ortholog of human EGF (epidermal growth factor).