WBGene00006766 | SMap | S_parent | Sequence | B0564 |
| Identity | Version | 1 |
| | Name | CGC_name | unc-30 | Person_evidence | WBPerson261 |
| | | Sequence_name | B0564.10 |
| | | Molecular_name (12) |
| | | Other_name | CELE_B0564.10 | Accession_evidence | NDB | BX284604 |
| | | Public_name | unc-30 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143025 |
| | Allele (113) |
| | Legacy_information | e191 : shrinker contracts both dorsally and ventrally when touched; slow good forward movement but poor backing rather small; VD and DD motoneuron axons are displaced and fail to stain with anti-GABA antibodies. ES3 ME2 NA8 (e165 e318 etc.). |
| | | See also e845, e2384, e2505 |
| | | [C.elegansII] e191 : shrinker, contracts both dorsally and ventrally when touched; slow good forward movement but poor backing, rather small; VD and DD motoneuron axons are displaced and fail to stain with anti-GABA antibodies; PVP neurons also abnormal.ES3 ME2 OA>10: e165, e318, e646 (R44och), e926pdi (deletion), e2505, bx8, etc.). Cloned: encodes predicted 318 aa protein with homeodomain, most similar to UNC-4. Antibody stains D neurons, certain other neurons. Ectopic trans gene expression induces GABA expression. Locus naturally duplicated in some strains. [McIntire et al. 1993; Jin et al. 1994; CZ; MT] |
| | Strain (18) |
| | RNASeq_FPKM (74) |
| | GO_annotation (22) |
| | Ortholog (40) |
| | Paralog (20) |
| | Structured_description | Concise_description | unc-30 encodes a homeodomain-containing protein that is orthologous to the Pitx family of homeodomain transcription factors; during develpoment, UNC-30 controls the terminal differentiation of all 19 type D GABA-ergic motor neurons by directly regulating the expression of UNC-25/GAD and UNC-47/VGAT, which regulate GABA formation and secretion, respectively; UNC-30 is expressed most strongly in type D motor neurons during early L1 and L2 larval stages. | Paper_evidence | WBPaper00002082 |
| | | | | | WBPaper00003619 |
| | | | | | WBPaper00004839 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 03 Jul 2007 00:00:00 |
| | | Automated_description | Enables sequence-specific DNA binding activity. Involved in neuron differentiation; positive regulation of transcription by RNA polymerase II; and regulation of locomotion. Located in nucleus. Expressed in GABAergic neurons; ganglia; intestine; and ventral cord neurons. Human ortholog(s) of this gene implicated in Arts syndrome; clubfoot; and eye disease (multiple). Is an ortholog of human PITX2 (paired like homeodomain 2) and PITX3 (paired like homeodomain 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model (11) |
| Molecular_info | Corresponding_CDS | B0564.10a |
| | | B0564.10b |
| | | B0564.10c |
| | | B0564.10d |
| | Corresponding_CDS_history | B0564.10:wp114 |
| | Corresponding_transcript | B0564.10a.1 |
| | | B0564.10b.1 |
| | | B0564.10c.1 |
| | | B0564.10d.1 |
| | Other_sequence | L37867 |
| | | CBC05195_1 |
| | | Acan_isotig10301 |
| | | JI173604.1 |
| | | Dviv_isotig23393 |
| | | CJC03266_1 |
| | | Oden_isotig21606 |
| | Associated_feature (16) |
| | Gene_product_binds (51) |
| | Transcription_factor | WBTranscriptionFactor000218 |
| Experimental_info | RNAi_result | WBRNAi00090022 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00077587 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00009866 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00094906 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090181 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089777 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00039208 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00077590 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090340 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027624 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (12) |
| | Drives_construct (13) |
| | Construct_product | WBCnstr00007867 |
| | | WBCnstr00008192 |
| | | WBCnstr00016792 |
| | | WBCnstr00020007 |
| | | WBCnstr00034163 |
| | Regulate_expr_cluster | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | Antibody | WBAntibody00000092 |
| | Microarray_results (32) |
| | Expression_cluster | WBPaper00024970:GABAergic_neuron_specific |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037946:LIN-39_interacting |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_CoreEnriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_SelectivelyEnriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_larva_enriched |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00041222:unc-120(st364)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045316:prg-1_upregulated_L3 |
| | | WBPaper00045316:prg-1_upregulated_L4 |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00046121:mesoderm_unique |
| | | WBPaper00046338:intestine_unique |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049732:blmp-1(tm548)_vs_N2_upregulated |
| | | WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr) |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00055354:Allantoin_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Metformin_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058711:skn-1(lax188)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061340:AVD |
| | | WBPaper00061340:AVH |
| | | WBPaper00061340:AVJ |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:GLR |
| | | WBPaper00061340:PVP |
| | | WBPaper00061340:PVT |
| | | WBPaper00061340:RIB |
| | | WBPaper00061340:Z1_Z4 |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061651:AVJ_enriched |
| | | WBPaper00061651:PVP_enriched |
| | | WBPaper00061651:VD_DD_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062095:unc-4(e120)_upregulated_VA-neuron |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064933:bcf-1(ylf1)_upregulated_transcript |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:10_0 |
| | | WBPaper00065841:23_0 |
| | | WBPaper00065841:50_0 |
| | | WBPaper00065841:60_0 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045294:0.1uM_TBBP_upregulated |
| | | WBPaper00045294:50uM_TBBP_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00045807:microcystin-LR_upregulated |
| | | WBPaper00046853:AOBr_LakeStobenseeOct_upregulated |
| | | WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated |
| | | WBPaper00048563:L1_DD_enriched |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00051387:Triclosan_upregulated |
| | | [cgc5376]:let-60(G12V)-regulated_genes |
| | | [cgc5767]:cluster_28 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(101_min) |
| | | [cgc5767]:expression_class_E_pi(66_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SET |
| | | [cgc5767]:expression_class_SE_pi(66_min) |
| | Interaction (103) |
| | WBProcess | WBbiopr:00000010 |
| Map_info | Map | IV | Position | 8.21927 | Error | 0.023908 |
| | Well_ordered |
| | Positive | Inside_rearr | nDp3 |
| | | | sDf21 |
| | | | sDf22 |
| | | Positive_clone | B0564 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | CB#RH17 |
| | Mapping_data | 2_point | 97 |
| | | | 115 |
| | | | 121 |
| | | | 317 |
| | | | 479 |
| | | | 555 |
| | | | 729 |
| | | | 730 |
| | | | 823 |
| | | | 4659 |
| | | Multi_point (64) |
| | | Pos_neg_data (18) |
| | Landmark_gene |
| Reference | WBPaper00000030 |
| | WBPaper00000031 |
| | WBPaper00000079 |
| | WBPaper00000464 |
| | WBPaper00000592 |
| | WBPaper00000608 |
| | WBPaper00000978 |
| | WBPaper00001126 |
| | WBPaper00001254 |
| | WBPaper00001296 |
| | WBPaper00001345 |
| | WBPaper00001709 |
| | WBPaper00001736 |
| | WBPaper00001759 |
| | WBPaper00001780 |
| | WBPaper00001847 |
| | WBPaper00002082 |
| | WBPaper00002134 |
| | WBPaper00002272 |
| | WBPaper00002413 |
| | WBPaper00002837 |
| | WBPaper00003309 |
| | WBPaper00003317 |
| | WBPaper00003509 |
| | WBPaper00003619 |
| | WBPaper00003792 |
| | WBPaper00004217 |
| | WBPaper00004257 |
| | WBPaper00004362 |
| | WBPaper00004379 |
| | WBPaper00004409 |
| | WBPaper00004458 |
| | WBPaper00004839 |
| | WBPaper00004883 |
| | WBPaper00005237 |
| | WBPaper00005423 |
| | WBPaper00005455 |
| | WBPaper00005511 |
| | WBPaper00005543 |
| | WBPaper00005939 |
| | WBPaper00006286 |
| | WBPaper00006288 |
| | WBPaper00006497 |
| | WBPaper00011119 |
| | WBPaper00011461 |
| | WBPaper00011743 |
| | WBPaper00013729 |
| | WBPaper00013780 |
| | WBPaper00013783 |
| | WBPaper00013816 |
| | WBPaper00013864 |
| | WBPaper00013898 |
| | WBPaper00013899 |
| | WBPaper00013983 |
| | WBPaper00014118 |
| | WBPaper00014220 |
| | WBPaper00014258 |
| | WBPaper00014275 |
| | WBPaper00014712 |
| | WBPaper00014787 |
| | WBPaper00014863 |
| | WBPaper00015153 |
| | WBPaper00015403 |
| | WBPaper00015440 |
| | WBPaper00015479 |
| | WBPaper00015530 |
| | WBPaper00015616 |
| | WBPaper00015635 |
| | WBPaper00015656 |
| | WBPaper00015718 |
| | WBPaper00016304 |
| | WBPaper00016405 |
| | WBPaper00016473 |
| | WBPaper00016504 |
| | WBPaper00016536 |
| | WBPaper00016671 |
| | WBPaper00016974 |
| | WBPaper00017088 |
| | WBPaper00017232 |
| | WBPaper00017302 |
| | WBPaper00017320 |
| | WBPaper00017491 |
| | WBPaper00018015 |
| | WBPaper00018797 |
| | WBPaper00019199 |
| | WBPaper00020971 |
| | WBPaper00021969 |
| | WBPaper00022132 |
| | WBPaper00022255 |
| | WBPaper00022306 |
| | WBPaper00022474 |
| | WBPaper00022853 |
| | WBPaper00022973 |
| | WBPaper00022996 |
| | WBPaper00022998 |
| | WBPaper00023052 |
| | WBPaper00023444 |
| | WBPaper00023508 |
| | WBPaper00023766 |
| | WBPaper00023818 |
| | WBPaper00023942 |
| | WBPaper00023983 |
| | WBPaper00024160 |
| | WBPaper00024317 |
| | WBPaper00024970 |
| | WBPaper00025052 |
| | WBPaper00025150 |
| | WBPaper00025755 |
| | WBPaper00027250 |
| | WBPaper00027299 |
| | WBPaper00027309 |
| | WBPaper00028114 |
| | WBPaper00028874 |
| | WBPaper00029020 |
| | WBPaper00030219 |
| | WBPaper00031213 |
| | WBPaper00031671 |
| | WBPaper00032358 |
| | WBPaper00032446 |
| | WBPaper00032564 |
| | WBPaper00034710 |
| | WBPaper00035198 |
| | WBPaper00036652 |
| | WBPaper00036778 |
| | WBPaper00038491 |
| | WBPaper00040284 |
| | WBPaper00041515 |
| | WBPaper00042634 |
| | WBPaper00042846 |
| | WBPaper00043299 |
| | WBPaper00043622 |
| | WBPaper00043673 |
| | WBPaper00043908 |
| | WBPaper00046074 |
| | WBPaper00046510 |
| | WBPaper00046950 |
| | WBPaper00047912 |
| | WBPaper00047916 |
| | WBPaper00049006 |
| | WBPaper00050135 |
| | WBPaper00052103 |
| | WBPaper00052219 |
| | WBPaper00052777 |
| | WBPaper00053207 |
| | WBPaper00055090 |
| | WBPaper00056012 |
| | WBPaper00056064 |
| | WBPaper00057202 |
| | WBPaper00059551 |
| | WBPaper00060123 |
| | WBPaper00061272 |
| | WBPaper00061439 |
| | WBPaper00061622 |
| | WBPaper00061738 |
| | WBPaper00062340 |
| | WBPaper00062568 |
| | WBPaper00063704 |
| | WBPaper00064000 |
| | WBPaper00064037 |
| | WBPaper00064789 |
| | WBPaper00066019 |
| Method | Gene |