WormBase Tree Display for Gene: WBGene00000253

WBGene00000253 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 2
    Name: CGC_name: bli-3 Person_evidence: WBPerson261
      Sequence_name: F56C11.1
      Molecular_name: F56C11.1
        F56C11.1.1
        CE28463
        F56C11.1.2
      Other_name: tag-31 CGC_data_submission
        duox-1 Paper_evidence: WBPaper00004841
            WBPaper00006395
          Person_evidence: WBPerson56
        CELE_F56C11.1 Accession_evidence: NDB BX284601
      Public_name: bli-3
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 07 Sep 2009 12:21:16 WBPerson9133 Name_change: CGC_name: duox-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: bli
    Reference_allele: WBVar00143469
    Allele (139)
    Legacy_information: e767 : small irregular shape variable slight blistering in adult. ES2 (adult late larvae) ME1. NA1.
      See also e767, n529
      [C.elegansII]e767 : small irregular shape variable slight blistering in adult. ES2 (adult late larvae) ME1. OA1: n529. [Brenner 1974; CB]
    Strain: WBStrain00005170
      WBStrain00005171
      WBStrain00005172
      WBStrain00005173
      WBStrain00026799
      WBStrain00026835
      WBStrain00027251
      WBStrain00028999
      WBStrain00037731
      WBStrain00004204
    RNASeq_FPKM (74)
    GO_annotation (36)
    Ortholog: WBGene00070507 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00027637 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00162854 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00159126 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00126923 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00114201 Pristionchus pacificus From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00224727 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g12331 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g12206 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP21.g15043 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP21.g1901 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP21.g1902 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g6577 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP29.g11006 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g10764 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g8818 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g10795 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP38.g10796 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g17497 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g17826 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g7069 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g7353 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g5320 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cnig_chr_I.g416 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g14582 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01692.g22567 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_06360 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_001329 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12957 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12958 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g11380 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10247800 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g26 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00245165 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00262944 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00289879 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0283531 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-091117-14 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      HGNC:13273 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:3062 Homo sapiens From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:3036280 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:628761 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Paralog: WBGene00018771 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Concise_description: bli-3 encodes an NADPH oxidases of the dual oxidase (DUOX) variety that contains an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; BLI-3 is required for dityrosine cross-linking of collagen, and thus for cuticular integrity; BLI-3 is thought to use cytosolic NADPH to generate reactive oxygen, which then drives the peroxidase ectodomain to cross-link free tyrosine in collagen; BLI-3 is expressed exclusively in hypodermal cells at low levels, with peaks of expression corresponding to collagen/cuticle biosynthesis. Paper_evidence: WBPaper00000031
            WBPaper00002665
            WBPaper00004841
            WBPaper00005747
            WBPaper00033104
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 19 Aug 2009 00:00:00
      Automated_description: Enables NAD(P)H oxidase H2O2-forming activity; heme binding activity; and peroxidase activity. Involved in several processes, including cuticle development involved in collagen and cuticulin-based cuticle molting cycle; defense response to other organism; and post-embryonic development. Located in plasma membrane. Expressed in hypodermis; intestine; and neurons. Used to study phenylketonuria. Human ortholog(s) of this gene implicated in cholera; inflammatory bowel disease (multiple); and thyroid dyshormonogenesis 6. Is an ortholog of human DUOX2 (dual oxidase 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9281
    Potential_model: DOID:0050328 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:13273)
      DOID:8577 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:13273)
      DOID:1498 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:13273)
      DOID:8778 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:13273)
      DOID:0112189 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:13273)
  Models_disease_asserted: WBDOannot00000626
  Molecular_info: Corresponding_CDS: F56C11.1
    Corresponding_transcript: F56C11.1.1
      F56C11.1.2
    Other_sequence (17)
    Associated_feature: WBsf717434
      WBsf982412
      WBsf982413
      WBsf982414
      WBsf1009036
      WBsf218873
      WBsf218874
  Experimental_info: RNAi_result (35)
    Expr_pattern: Expr2613
      Expr15757
      Expr1010236
      Expr1030163
      Expr1152411
      Expr2009629
      Expr2027868
    Drives_construct: WBCnstr00021138
      WBCnstr00037626
      WBCnstr00042508
    Construct_product: WBCnstr00015484
      WBCnstr00015485
      WBCnstr00015489
      WBCnstr00015491
      WBCnstr00037626
    Antibody: WBAntibody00000404
      WBAntibody00002391
      WBAntibody00002392
    Microarray_results (21)
    Expression_cluster: WBPaper00030922:glycosylated_protein
      WBPaper00031040:Cluster_5
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00036291:ung-1_regulated
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(gk119)_upregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045934:wrn-1(gk99)_downregulated
      WBPaper00046121:mesoderm_unique
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049732:blmp-1(tm548)_vs_N2_upregulated
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051558:aging_regulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053615:SMO-1_target
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055648:male-tail_expressed
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00056855:his-72(uge40)_upregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061007:HB101_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ILso
      WBPaper00061340:Seam_cell
      WBPaper00061527:Y37D8A.16-F54D1.6_15313
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:0_0
      WBPaper00065841:30_2
      WBPaper00065841:30_5
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_4_6
      cgc4489_group_22
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00035504:daf-2(e1370)_upregulated
      WBPaper00036286:Pattern_I
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00037695:DD_3-day
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      [cgc6390]:Cluster_B
    Interaction (22)
    WBProcess: WBbiopr:00000039
      WBbiopr:00000096
  Map_info: Map: I Position: -19.1485 Error: 0.002825
    Well_ordered
    Positive: Inside_rearr: sDp2
      Positive_clone: F56C11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 1
        2504
        3941
        4741
        6080
        7166
        7167
        7169
      Multi_point (18)
      Pos_neg_data: 6276
        1026
        955
        4553
        4554
        4555
        4556
    Landmark_gene
  Reference (58)
  Remark: Gene name created from parsing 'genotype' field from CGC strain information CGC_data_submission
  Method: Gene