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WormBase Tree Display for Gene: WBGene00020442

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Name Class

WBGene00020442SMapS_parentSequenceT12A2
IdentityVersion2
NameCGC_namegen-1Paper_evidenceWBPaper00036708
Person_evidenceWBPerson195
Sequence_nameT12A2.8
Molecular_nameT12A2.8
T12A2.8.1
CE01401
Other_nameCELE_T12A2.8Accession_evidenceNDBBX284603
Public_namegen-1
DB_infoDatabaseAceViewgene3H336
WormQTLgeneWBGene00020442
WormFluxgeneWBGene00020442
NDBlocus_tagCELE_T12A2.8
PanthergeneCAEEL|WormBase=WBGene00020442|UniProtKB=Q22418
familyPTHR11081
NCBIgene175885
RefSeqproteinNM_065960.5
TREEFAMTREEFAM_IDTF101235
TrEMBLUniProtAccQ22418
UniProt_GCRPUniProtAccQ22418
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:03WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
203 Aug 2010 10:05:58WBPerson2970Name_changeCGC_namegen-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classgen
Allele (42)
StrainWBStrain00034666
RNASeq_FPKM (74)
GO_annotation00075195
00075196
00075197
00075198
00075199
00075200
00075201
00075202
00075203
00075204
00075205
00075206
00075207
00075208
00075209
00125077
00125078
00125079
Contained_in_operonCEOP3360
Ortholog (22)
ParalogWBGene00000794Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00009731Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00019004Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptiongen-1 encodes the C. elegans homolog of the human GEN1 Holliday Junction resolving enzyme; in C. elegans, GEN-1 activity is required for DNA double-strand break repair and ionizing radiation-induced cell cycle arrest and apoptosis, independent of the CEP-1/p53 pathway, as part of a DNA damage signaling response; GEN-1 exhibits in vitro nuclease activity consistent with it functioning as a junction-resolving enzyme.Paper_evidenceWBPaper00036708
Curator_confirmedWBPerson1843
Date_last_updated05 Jan 2012 00:00:00
Automated_descriptionEnables crossover junction DNA endonuclease activity. Involved in DNA damage response and negative regulation of nematode larval development. Predicted to be located in cytoplasm and nucleus.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDST12A2.8
Corresponding_transcriptT12A2.8.1
Other_sequenceCJC11994_1
CRC01733_1
Dviv_contig26186
Oden_isotig10028
Oden_isotig10029
CR04857
Oden_isotig10027
Associated_featureWBsf651109
WBsf651110
WBsf976164
WBsf976165
WBsf992691
WBsf1015055
WBsf226791
WBsf226792
Experimental_infoRNAi_result (28)
Expr_patternExpr1024502
Expr1038917
Expr1156757
Expr2012020
Expr2030256
Drives_constructWBCnstr00025138
Construct_productWBCnstr00025138
AntibodyWBAntibody00002201
Microarray_results (22)
Expression_clusterWBPaper00036375:enriched_in_PVD_OLL
WBPaper00037946:LIN-39_interacting
WBPaper00044736:flat_dev_expression
WBPaper00045729:gld-2(RNAi)_downregulated
WBPaper00048762:FOG-3_associated
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050903:mir-35-41(nDf50)_20C_upregulated
WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:pharynx_expressed
WBPaper00051039:germline_enriched
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_embryo_SMARTseq
WBPaper00054792:FOG-3_interacting
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin_upregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin_downregulated
WBPaper00055648:germline_expressed
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00057288:Cold_upregulated_transcript
WBPaper00058691:cfp-1(tm6369)_upregulated
WBPaper00058691:sin-3(tm1276)_upregulated
WBPaper00059174:MEG-3_interacting
WBPaper00060014:set-2(tm1630)_upregulated
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00061340:ALN
WBPaper00061439:unc-30(ok613)_downregulated
WBPaper00061527:hrdl-1_3731-lst-4_2238
WBPaper00061527:lst-4_22151-F46F11.6_12556
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064716:paraquat_upregulated
WBPaper00064871:hypoxia_upregulated_F1
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4386_cluster_3_3
cgc4489_group_2
cgc4489_group_9
WBPaper00025032:cluster_1
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00031832:slr-2_regulated
WBPaper00034739:N2moreDR1350
WBPaper00035905:FBF-1_Associated
WBPaper00037611:RNP-8-associated
WBPaper00037695:LD_DD_6-day
WBPaper00037901:GLD-1_mRNA_targets
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040876:mir-35_upregulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00048624:hlh-25(ok1710)_upregulated
WBPaper00053236:Starvation_regulated_GR1307
[cgc5767]:cluster_1
[cgc5767]:expression_class_M
[cgc5767]:expression_class_MD
[cgc5767]:expression_class_MD_pd(PC32)
[cgc5767]:expression_class_SM
[cgc5767]:expression_class_SMD
[cgc6390]:Cluster_F
[cgc6390]:herm_sex-enriched
[cgc6390]:oogenesis-enriched
InteractionWBInteraction000051783
WBInteraction000051784
WBInteraction000051785
WBInteraction000198930
WBInteraction000201909
WBInteraction000277157
WBInteraction000449622
WBInteraction000563416
WBInteraction000563417
WBInteraction000563418
Map_infoMapIIIPosition-1.40795Error9.2e-05
PositivePositive_cloneT12A2Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (12)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene