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WormBase Tree Display for Gene: WBGene00002244

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Name Class

WBGene00002244SMapS_parentSequenceY71H2AM
IdentityVersion2
NameCGC_namelaf-1Paper_evidenceWBPaper00033079
Person_evidenceWBPerson213
Sequence_nameY71H2AM.19
Molecular_nameY71H2AM.19
Y71H2AM.19.1
CE47305
Other_nameCELE_Y71H2AM.19Accession_evidenceNDBBX284603
Public_namelaf-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:27WBPerson1971EventImportedInitial conversion from geneace
207 May 2009 15:45:20WBPerson1847EventAcquires_mergeWBGene00022184
Acquires_mergeWBGene00022184
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlaf
Allele (319)
Possibly_affected_byWBVar02154084
StrainWBStrain00003812
RNASeq_FPKM (74)
GO_annotation00007113
00007114
00007115
00007116
00007117
00007118
00007119
00007120
00007121
00007122
00007123
00007124
00007125
00007126
00007127
00007128
00007129
00007130
00007131
00007132
00007133
00007134
00007135
00007136
00007137
00007138
00007139
00007140
00007141
00007142
00007143
00007144
00007145
00007146
00007147
00007148
00007149
00007150
00007151
00007152
00007153
00110284
00110285
Ortholog (43)
Paralog (37)
Structured_descriptionConcise_descriptionlaf-1 encodes a DEAD-box RNA helicase; laf-1 is required for embryonic development and sex determination; laf-1 was identified in screens for dominant suppressors of the sterility produced by gain-of-function fem-3 mutations; when homozygous, laf-1 mutations result in embryonic and larval lethality and when heterozygous, feminization of XX and XO animals; reporter gene analyses indicate that wild-type laf-1 activity is required for proper translational repression of tra-2 mRNA via its 3'UTR; when expressed in embryos, LAF-1 localizes predominantly to the cytoplasm with additional localization seen in P granules.Paper_evidenceWBPaper00002662
WBPaper00033079
Curator_confirmedWBPerson1843
Date_last_updated09 Sep 2009 00:00:00
Automated_descriptionEnables RNA strand annealing activity; identical protein binding activity; and molecular condensate scaffold activity. Involved in several processes, including masculinization of hermaphroditic germ-line; positive regulation of embryonic development; and positive regulation of fertilization. Located in P granule. Expressed in germ line. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and syndromic X-linked intellectual disability. Is an ortholog of human DDX3X (DEAD-box helicase 3 X-linked) and DDX3Y (DEAD-box helicase 3 Y-linked).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:9256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2745)
DOID:0060309Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2745)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2745)
Molecular_infoCorresponding_CDSY71H2AM.19
Corresponding_CDS_historyY71H2AM.19a:wp275
Corresponding_transcriptY71H2AM.19.1
Other_sequence (56)
Associated_featureWBsf976054
WBsf991601
WBsf991602
WBsf1014456
WBsf1014457
WBsf226303
WBsf226304
Experimental_infoRNAi_resultWBRNAi00058241Inferred_automaticallyRNAi_primary
WBRNAi00116331Inferred_automaticallyRNAi_primary
WBRNAi00075501Inferred_automaticallyRNAi_primary
WBRNAi00058240Inferred_automaticallyRNAi_primary
WBRNAi00116333Inferred_automaticallyRNAi_primary
WBRNAi00078430Inferred_automaticallyRNAi_primary
WBRNAi00078432Inferred_automaticallyRNAi_primary
WBRNAi00116332Inferred_automaticallyRNAi_primary
Expr_pattern (6)
Drives_constructWBCnstr00042407
Construct_productWBCnstr00042407
AntibodyWBAntibody00002638
Microarray_results (27)
Expression_clusterWBPaper00032031:DConiospora_upregulated_OligoArray_24h
WBPaper00034640:Phosphorylated_protein
WBPaper00037047:insoluble_protein
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00038289:oocyte_protein
WBPaper00040221:DAF-12_target_ALF4
WBPaper00041072:UTX-1_interacting_protein
WBPaper00044037:eat-2_downregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045316:prg-1_upregulated_L1
WBPaper00045316:prg-1_upregulated_L2
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00046499:AMPK_regulated
WBPaper00046509:htz-1(ok3099)_downregulated
WBPaper00046509:lin-35(n745)_downregulated
WBPaper00047131:daf-2(e1370)_downregulated_N2-background
WBPaper00048988:neuron_expressed
WBPaper00049498:npr-1(ur89)_regulated_3
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049732:blmp-1(tm548)_vs_N2_upregulated
WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
WBPaper00050234:lin-28(RNAi)_upregulated
WBPaper00050686:glp-1(e2141)_downregulated
WBPaper00050698:DEP-1_interacting
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051265:F1_morc-1(tm6048)_downregulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053302:zidovudine_24h_regulated
WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
WBPaper00053810:daf-2(e1370)_downregulated
WBPaper00053810:isp-1(qm150)_downregulated
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00053814:25C_downregulated_OP50
WBPaper00053814:25C_downregulated_PY79
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055226:ADR-2_target_N2
WBPaper00055334:DLC-1_interacting
WBPaper00055482:pmt-2(RNAi)_downregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055648:germline_expressed
WBPaper00055941:nuo-6(qm200)_downregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_downregulated_N2
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056284:INTS-6_interacting_protein
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00057288:Cold_downregulated_protein
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058691:CFP-1_interacting_protein
WBPaper00058691:WDR-5.1_interacting_protein
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00059471:EGL-43_interacting
WBPaper00059605:MUT-16_interacting
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060908:TEBP-2_interacting
WBPaper00061341:28C_24h_downregulated
WBPaper00061341:28C_48h_downregulated
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061527:pro-3_11683-C44E4.1_9745
WBPaper00062143:PQN-59_interacting
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062498:PPM-1.D_interacting
WBPaper00062554:MAGU-2_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064055:trl-1(cas1077)_upregulated_non-starved
WBPaper00064055:trl-1(cas1077)_upregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064716:paraquat_upregulated
WBPaper00064871:hypoxia_upregulated_F2
WBPaper00065120:body-muscle-transcriptome
WBPaper00065149:lin-52(n771)_downregulated
WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
WBPaper00065975:P-body_vs_WholeAnimal_enriched
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
WBPaper00030985:Erwinia_carotovora_downregulated
WBPaper00030985:Serratia_marcesens_downregulated
WBPaper00031252:AIN-2_IP_enriched
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00036286:Pattern_D
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040858:eQTL_regulated_old
WBPaper00041174:genotypic
WBPaper00041174:genotypic_prime
WBPaper00041609:hpl-1_hpl-2_downregulated
WBPaper00041939:control_vs_EtBr-exposed_3h
WBPaper00041939:control_vs_UVC-exposed_3h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_3h
WBPaper00042128:gei-8(ok1671)_downregulated
WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
WBPaper00048989:N2_rapamycin_upregulated
Interaction (55)
Map_infoMapIIIPosition-10.2047Error0.03232
PositivePositive_cloneY71H2AMInferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point7053
Multi_point3526
Reference (44)
MethodGene