WormBase Tree Display for Gene: WBGene00000482

WBGene00000482 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: chd-3 Person_evidence: WBPerson8
      Sequence_name: T14G8.1
      Molecular_name: T14G8.1
        T14G8.1.1
        CE03657
      Other_name: CELE_T14G8.1 Accession_evidence: NDB BX284606
      Public_name: chd-3
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: chd
    Allele (121)
    Strain: WBStrain00032145
      WBStrain00008565
    RNASeq_FPKM (74)
    GO_annotation: 00075476
      00075477
      00075478
      00075479
      00075480
      00075481
      00075482
      00075483
      00075484
      00075485
      00075486
      00075487
      00075488
      00075489
      00075490
      00075491
      00075492
      00075493
      00075494
      00075495
      00075496
      00075497
      00075498
      00075499
      00075500
      00075501
      00075502
      00075503
      00075504
      00075505
      00075506
      00075507
      00107469
      00107470
      00107471
      00107472
    Ortholog (44)
    Paralog (19)
    Structured_description: Concise_description: chd-3 encodes a PHD-finger SNF2 family member containing a chromo domain and a C-terminal helicase domain that affects Notch-dependent vulval development; expressed in virtually all embryonic cells and in many larval nuclei. Paper_evidence: WBPaper00004171
            WBPaper00004491
            WBPaper00018132
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable several functions, including ATP hydrolysis activity; ATP-dependent activity, acting on DNA; and chromatin binding activity. Involved in cell fate determination; negative regulation of Ras protein signal transduction; and negative regulation of vulval development. Predicted to be located in nucleus. Predicted to be part of NuRD complex. Expressed in several structures, including distal tip cell; pharynx; ventral nerve cord; vulva; and vulval precursor cell. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung adenocarcinoma; and lymphoma. Is an ortholog of human CHD3 (chromodomain helicase DNA binding protein 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1919)
      DOID:1993 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1919)
      DOID:3910 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1919)
      DOID:1324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1919)
      DOID:234 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1919)
      DOID:0060058 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1919)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:16816,HGNC:1919)
  Molecular_info: Corresponding_CDS: T14G8.1
    Corresponding_transcript: T14G8.1.1
    Other_sequence (39)
    Associated_feature: WBsf655713
      WBsf671155
      WBsf671156
      WBsf671157
      WBsf1007448
      WBsf1024138
      WBsf238087
  Experimental_info: RNAi_result: WBRNAi00018728 Inferred_automatically: RNAi_primary
      WBRNAi00053345 Inferred_automatically: RNAi_primary
      WBRNAi00075564 Inferred_automatically: RNAi_primary
      WBRNAi00070008 Inferred_automatically: RNAi_primary
      WBRNAi00081570 Inferred_automatically: RNAi_primary
      WBRNAi00113476 Inferred_automatically: RNAi_primary
      WBRNAi00035580 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1044
      Expr9223
      Expr1020503
      Expr1030284
      Expr1156930
      Expr2009956
      Expr2028196
    Drives_construct: WBCnstr00010045
      WBCnstr00013809
      WBCnstr00037504
      WBCnstr00038090
    Construct_product (2)
    Regulate_expr_cluster: WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4)_upregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_upregulated_100-cell-embryo
    Antibody: WBAntibody00002259
    Microarray_results (18)
    Expression_cluster: WBPaper00032976:dosage_compensated_genes
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037946:MAB-5_interacting
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Oogenic
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00046338:body_muscle_unique
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00048926:miaserin_upregulated_adult-day10
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049217:DAF-16_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00050094:mes-2(bn11)_upregulated
      WBPaper00050094:mes-6(bn66)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:nucleus_specific
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056039:ptl-1(ok621)_upregulated
      WBPaper00056139:gut-microbiota_downregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00058969:RIS_enriched
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059440:GLP-1_activated
      WBPaper00059471:EGL-43_interacting
      WBPaper00060084:DVE-1_interacting_protein_cco-1(RNAi)
      WBPaper00060084:DVE-1_interacting_protein_control
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061340:ASE_parent
      WBPaper00061340:ASG_AWA
      WBPaper00061340:Neuroblast_ASJ_AUA
      WBPaper00061340:Neuroblast_AVG_RIR
      WBPaper00061340:Neuroblast_M2_M3
      WBPaper00061340:Pharyngeal_neuron
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061478:pie-1(ne4433)_upregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:cfz-2_18944-cfz-2_2268
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00064055:trl-1(cas1077)_upregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-3(bn199)_upregulated_PGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065149:lin-52(n771)_downregulated
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066085:sin-3(tm1276)_upregulated
      WBPaper00066093:E.coli-purE_downregulated
      WBPaper00066110:Doxorubicin_downregulated_diploid
      cgc4386_cluster_6_3
      cgc4489_group_5
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025032:cluster_2
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00033101:spr-5_regulated
      WBPaper00036286:Pattern_D
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041960:daf-16_fasting_upregulated
      WBPaper00041960:kgb-1_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045263:ProLongevity-mtROS_upregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053550:daf-19(m86)_downregulated_AdultDay2
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(41_min)
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
    Interaction (66)
  Map_info: Map: X Position: 8.51882 Error: 0.073253
    Positive: Positive_clone: T14G8 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4215
        4883
        5508
    Pseudo_map_position
  Reference (38)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene