WormBase Tree Display for Gene: WBGene00001401
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| WBGene00001401 | SMap | S_parent | Sequence | H12I13 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | fbf-1 | Person_evidence | WBPerson320 | |||||
| Sequence_name | H12I13.4 | ||||||||
| Molecular_name | H12I13.4 | ||||||||
| H12I13.4.1 | |||||||||
| CE20960 | |||||||||
| Other_name | FBF | Paper_evidence | WBPaper00053101 | ||||||
| WBPaper00053705 | |||||||||
| CELE_H12I13.4 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | fbf-1 | ||||||||
| DB_info | Database | AceView | gene | 2G370 | |||||
| WormQTL | gene | WBGene00001401 | |||||||
| WormFlux | gene | WBGene00001401 | |||||||
| NDB | locus_tag | CELE_H12I13.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001401|UniProtKB=Q9N5M6 | |||||||
| family | PTHR12537 | ||||||||
| NCBI | gene | 174016 | |||||||
| RefSeq | protein | NM_062815.8 | |||||||
| SwissProt | UniProtAcc | Q9N5M6 | |||||||
| TREEFAM | TREEFAM_ID | TF318622 | |||||||
| UniProt_GCRP | UniProtAcc | Q9N5M6 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fbf | ||||||||
| Allele (53) | |||||||||
| Legacy_information | [Gallegos M, Zhang B] fbf-1(RNAi) animals produce excess sperm and no oocytes (Mog phenotype). Encodes fem-3 PME RNA binding protein, 91% identical to FBF-2 | ||||||||
| Strain | WBStrain00022602 | ||||||||
| WBStrain00022603 | |||||||||
| WBStrain00022612 | |||||||||
| WBStrain00022628 | |||||||||
| WBStrain00022640 | |||||||||
| WBStrain00022344 | |||||||||
| WBStrain00022346 | |||||||||
| WBStrain00022396 | |||||||||
| WBStrain00022400 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (33) | |||||||||
| Paralog | WBGene00004239 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001402 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00022257 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004241 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004243 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004242 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004240 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| WBGene00004244 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004245 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | fbf-1 encodes an RNA-binding protein that is one of 12 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-1 is nearly identical to FBF-2 with which it is largely redundant in regulating two aspects of germline development: 1) maintenance of stem cell proliferation, and 2) the hermaphroditic switch between spermatogenesis and oogenesis; FBF-1 also plays a role in regulating adaptation in the AWC chemosensory neuron by binding and enhancing translation of the egl-4 mRNA; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages. | Paper_evidence | WBPaper00002949 | |||||
| WBPaper00004396 | |||||||||
| WBPaper00005265 | |||||||||
| WBPaper00005566 | |||||||||
| WBPaper00006369 | |||||||||
| WBPaper00032496 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Feb 2009 00:00:00 | ||||||||
| Automated_description | Enables mRNA 3'-UTR binding activity. Involved in several processes, including germline cell cycle switching, mitotic to meiotic cell cycle; olfactory learning; and regulation of gene expression. Located in germ cell nucleus and perinuclear region of cytoplasm. Expressed in germ line. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed (2) | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | H12I13.4 | |||||||
| Corresponding_transcript | H12I13.4.1 | ||||||||
| Associated_feature | WBsf650110 | ||||||||
| WBsf1012315 | |||||||||
| WBsf223128 | |||||||||
| Gene_product_binds | WBsf027922 | ||||||||
| WBsf034330 | |||||||||
| Transcription_factor | WBTranscriptionFactor000123 | ||||||||
| WBTranscriptionFactor000103 | |||||||||
| Experimental_info | RNAi_result (58) | ||||||||
| Expr_pattern | Expr1450 | ||||||||
| Expr1452 | |||||||||
| Expr1892 | |||||||||
| Expr3517 | |||||||||
| Expr3519 | |||||||||
| Expr3796 | |||||||||
| Expr13083 | |||||||||
| Expr14531 | |||||||||
| Expr14596 | |||||||||
| Expr15895 | |||||||||
| Expr1030839 | |||||||||
| Expr1153116 | |||||||||
| Expr2011443 | |||||||||
| Expr2029681 | |||||||||
| Drives_construct | WBCnstr00005287 | ||||||||
| WBCnstr00036969 | |||||||||
| Construct_product | WBCnstr00000086 | ||||||||
| WBCnstr00005234 | |||||||||
| WBCnstr00036969 | |||||||||
| WBCnstr00040358 | |||||||||
| WBCnstr00042579 | |||||||||
| Regulate_expr_cluster | WBPaper00035905:FBF-1_Associated | ||||||||
| WBPaper00045618:fbf-1_downregulated | |||||||||
| WBPaper00045618:fbf-1_upregulated | |||||||||
| WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched | |||||||||
| WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched | |||||||||
| Antibody | WBAntibody00000156 | ||||||||
| WBAntibody00000784 | |||||||||
| WBAntibody00000964 | |||||||||
| WBAntibody00001086 | |||||||||
| WBAntibody00002142 | |||||||||
| WBAntibody00002385 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (131) | |||||||||
| Interaction (89) | |||||||||
| Map_info | Map | II | Position | -0.571982 | Error | 0.010563 | |||
| Positive | Positive_clone | H12I13 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Y56A9 | |||||||||
| Mapping_data | Multi_point | 4304 | |||||||
| 4305 | |||||||||
| 5274 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (142) | |||||||||
| Picture | WBPicture0000013095 | ||||||||
| Remark (2) | |||||||||
| Method | Gene |
