WormBase Tree Display for Gene: WBGene00003012
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WBGene00003012 | SMap | S_parent | Sequence | F18A1 | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | lin | |||||
Reference_allele | WBVar00089290 | |||||
Allele (43) | ||||||
Legacy_information | n156 : adult hermaphrodites vulvaless ( > 99%) slightly small and fat HME1. ES2. Males very small scrawny rounded tail ME0. n156/Df is larval lethal. NA1. | |||||
[Labouesse M] n156 animals were injected together with rol-6(su1006) at 80 ng/microl and F2 rollers were picked and ability to lay eggs was scored as rescue (n156 animals are vulvaless and hence bag). The cosmids were injected at a concentration of 10 ng/microlitre or less. Further subcloning showed a 9 kb fragment from K06E5 to be sufficient to rescue n156. | ||||||
See also n156 | ||||||
[Labouesse M] mc2 and mc4 are embryonic lethals. mc2 mild loss-of-function, mc4 is strong. | ||||||
[Sookhareea S & Labouesse M] pk38/mc15 null mutation similar phenotype to mc1 & mc4. emb-lethal plus degeneration of hyp cells and glial cells. | ||||||
[C.elegansII] n156 : adult hermaphrodites vulvaless ( >99%), slightly small and fat; HME1. General hypodermal and support cell defects,hypodermal cells die or neuralize. 2% sterile.ES2. Males very small scrawny rounded tail; ME0. n156/Df is larval lethal. OA4: mc1, mc2 (both embryonic lethal),pk38tci, mc15 (deletion derivative). Cloned: encodes predicted zinc finger transcription factor. Antibody stains hypodermis,support cells, uterine cells. [Labouesse et al. 1994; MT; ML] | ||||||
Complementation_data | C18C9 (2 F2 rescued Rol/ 3 F2 lines); K06E5 (6 F2 rescuedRol lines / 6 F2 lines); C24G10 (0 F2 rescued Rol/ 2 lines and 0 F2 recued lines / 14 F2 Rol lines when injected in combination with C09G7); C36F4 (0 F2 rescued Rol lines/ 1 F2 Rol line); C18D9 ( 0 F2 rescued Rol line/ 1 F2 Rol) C43A1 (O rescued/ 3 F2 Rol lines); F31B8 (4 F2 recued Rol lines/ 6 F2 Rol lines) | |||||
Strain (15) | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation (19) | ||||||
Contained_in_operon | CEOP2300 | |||||
Ortholog (20) | ||||||
Paralog | WBGene00003044 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||
WBGene00003045 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00003046 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00010264 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00013350 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00018740 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00018833 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00304808 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
Structured_description | Concise_description | lin-26 encodes a zinc-finger protein that shares a unique C2H2 motif together with LIR-1, LIR-2, and LIR-3; during development, lin-26 activity is required for proper differentiation of non-neuronal ectodermal cells and the somatic gonad epithelium; LIN-26 is expressed in many different cell types including the rectal rep, somatic gonad, glial, and hypodermal cells; ectopic LIN-26 expression during embryogenesis induces epithelial-like cell fates suggesting that LIN-26 is sufficient for epithelial differentiation. | Paper_evidence | WBPaper00002025 | ||
WBPaper00002551 | ||||||
WBPaper00003169 | ||||||
WBPaper00003422 | ||||||
WBPaper00004780 | ||||||
Curator_confirmed | WBPerson1843 | |||||
Date_last_updated | 05 Dec 2006 00:00:00 | |||||
Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; tissue development; and vulval development. Located in nucleus. Expressed in several structures, including Z2; epithelial cell; germ line; gonad; and somatic gonad precursor. | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Molecular_info | Corresponding_CDS | F18A1.2a | ||||
F18A1.2b | ||||||
F18A1.2c | ||||||
F18A1.2d | ||||||
Corresponding_CDS_history | F18A1.2a:wp127 | |||||
F18A1.2b:wp127 | ||||||
Corresponding_transcript | F18A1.2a.1 | |||||
F18A1.2b.1 | ||||||
F18A1.2c.1 | ||||||
F18A1.2d.1 | ||||||
Other_sequence | Dviv_isotig25737 | |||||
CR09194 | ||||||
CR12344 | ||||||
Acan_isotig04726 | ||||||
CR01875 | ||||||
CR03487 | ||||||
CJC08342_1 | ||||||
Oden_isotig20186 | ||||||
CRC00413_1 | ||||||
Associated_feature | WBsf644403 | |||||
WBsf657865 | ||||||
WBsf657866 | ||||||
WBsf978570 | ||||||
WBsf988536 | ||||||
WBsf988537 | ||||||
WBsf1012586 | ||||||
WBsf221629 | ||||||
WBsf221630 | ||||||
WBsf221631 | ||||||
Transcription_factor | WBTranscriptionFactor000314 | |||||
Experimental_info | RNAi_result (25) | |||||
Expr_pattern | Expr87 | |||||
Expr587 | ||||||
Expr1325 | ||||||
Expr1410 | ||||||
Expr3951 | ||||||
Expr7320 | ||||||
Expr10345 | ||||||
Expr10346 | ||||||
Expr10347 | ||||||
Expr10348 | ||||||
Expr12969 | ||||||
Expr1013230 | ||||||
Expr1031406 | ||||||
Expr1148877 | ||||||
Expr2013170 | ||||||
Expr2031402 | ||||||
Marker34 | ||||||
Drives_construct (34) | ||||||
Construct_product | WBCnstr00000938 | |||||
WBCnstr00000939 | ||||||
WBCnstr00000940 | ||||||
WBCnstr00036285 | ||||||
Antibody | WBAntibody00000122 | |||||
WBAntibody00001543 | ||||||
Microarray_results (40) | ||||||
Expression_cluster (146) | ||||||
SAGE_tag (19) | ||||||
Interaction (140) | ||||||
Map_info | Map | II | Position | 0.516432 | ||
Well_ordered | ||||||
Positive | Inside_rearr | mcDf1 | Person_evidence | WBPerson351 | ||
mnDf88 | Person_evidence | WBPerson351 | ||||
mnDf105 | Person_evidence | WBPerson351 | ||||
Positive_clone | C18C9 | |||||
F18A1 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
F31B8 | ||||||
K06E5 | ||||||
Negative | Outside_rearr | mcDf3 | ||||
Negative_clone | C01D8 | |||||
C09G7 | ||||||
C18D9 | ||||||
C24G10 | ||||||
C36F4 | ||||||
F43A1 | ||||||
Mapping_data | Multi_point | 706 | ||||
707 | ||||||
708 | ||||||
709 | ||||||
710 | ||||||
711 | ||||||
4479 | ||||||
4530 | ||||||
5721 | ||||||
Pos_neg_data | 6903 | |||||
6904 | ||||||
6905 | ||||||
6906 | ||||||
6907 | ||||||
6908 | ||||||
6909 | ||||||
8955 | ||||||
10239 | ||||||
Landmark_gene | ||||||
Reference (137) | ||||||
Method | Gene |