WormBase Tree Display for Gene: WBGene00004244

WBGene00004244 SMap: S_parent: Sequence: C30G12
  Identity: Version: 2
    Name: CGC_name: puf-8 Person_evidence: WBPerson320
      Sequence_name: C30G12.7
      Molecular_name: C30G12.7
        C30G12.7.1
        CE37486
      Other_name: teg-2 Person_evidence: WBPerson555
        CELE_C30G12.7 Accession_evidence: NDB BX284602
      Public_name: puf-8
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change (2)
      Acquires_merge: WBGene00006564
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: puf
    Allele (42)
    Strain: WBStrain00022254
      WBStrain00022619
      WBStrain00022166
      WBStrain00022639
    RNASeq_FPKM (74)
    GO_annotation (13)
    Contained_in_operon: CEOP2292
    Ortholog (33)
    Paralog: WBGene00001401 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001402 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004239 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004241 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004242 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004243 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004245 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022257 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: puf-8 encodes a member of the PUF family of RNA binding proteins. Paper_evidence: WBPaper00042132
          Curator_confirmed: WBPerson1843
          Date_last_updated: 01 Apr 2014 00:00:00
      Automated_description: Enables mRNA 3'-UTR binding activity. Involved in male meiotic nuclear division; negative regulation of MAPK cascade; and spermatogenesis. Located in P granule and nuclear periphery. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; germ line; sperm; and vulva. Used to study obesity. Human ortholog(s) of this gene implicated in cerebellar ataxia type 47. Is an ortholog of human PUM1 (pumilio RNA binding family member 1) and PUM2 (pumilio RNA binding family member 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9970 Homo sapiens Paper_evidence: WBPaper00061889
          Curator_confirmed: WBPerson324
          Date_last_updated: 28 Jun 2022 00:00:00
    Potential_model: DOID:0111743 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14957)
  Models_disease_in_annotation: WBDOannot00001263
  Molecular_info: Corresponding_CDS: C30G12.7
    Corresponding_CDS_history: C30G12.7:wp130
    Corresponding_transcript: C30G12.7.1
    Other_sequence: CR01371
      CRC02691_1
      CJC01330_1
    Associated_feature: WBsf019217
      WBsf019218
      WBsf223321
    Gene_product_binds: WBsf899537
      WBsf899538
      WBsf899539
      WBsf899540
  Experimental_info: RNAi_result (24)
    Expr_pattern (11)
    Drives_construct: WBCnstr00005726
      WBCnstr00005727
      WBCnstr00010760
      WBCnstr00011786
      WBCnstr00017042
      WBCnstr00017521
      WBCnstr00017549
      WBCnstr00017550
      WBCnstr00017551
      WBCnstr00017552
      WBCnstr00035610
      WBCnstr00042788
    Construct_product: WBCnstr00005726
      WBCnstr00005727
      WBCnstr00017042
      WBCnstr00017521
      WBCnstr00017549
      WBCnstr00017550
      WBCnstr00017551
      WBCnstr00017552
      WBCnstr00035610
    Regulate_expr_cluster: WBPaper00045618:puf-8_downregulated
      WBPaper00045618:puf-8_upregulated
    Microarray_results (19)
    Expression_cluster (127)
    Interaction (43)
    WBProcess: WBbiopr:00000069
  Map_info: Map: II Position: 0.500136 Error: 0.000128
    Positive: Positive_clone: C30G12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4171
        4615
        5564
        3796
        3826
    Pseudo_map_position
  Reference: WBPaper00005710
    WBPaper00005965
    WBPaper00006101
    WBPaper00006404
    WBPaper00010803
    WBPaper00011464
    WBPaper00012436
    WBPaper00012443
    WBPaper00017836
    WBPaper00018387
    WBPaper00018711
    WBPaper00022995
    WBPaper00025899
    WBPaper00026235
    WBPaper00026678
    WBPaper00026919
    WBPaper00027224
    WBPaper00027300
    WBPaper00027472
    WBPaper00027802
    WBPaper00028032
    WBPaper00028346
    WBPaper00029090
    WBPaper00029255
    WBPaper00031972
    WBPaper00032448
    WBPaper00033124
    WBPaper00033153
    WBPaper00034373
    WBPaper00034378
    WBPaper00035609
    WBPaper00038491
    WBPaper00039559
    WBPaper00039579
    WBPaper00039617
    WBPaper00039623
    WBPaper00040262
    WBPaper00040437
    WBPaper00040660
    WBPaper00040695
    WBPaper00040947
    WBPaper00041018
    WBPaper00041322
    WBPaper00041369
    WBPaper00042071
    WBPaper00042132
    WBPaper00043728
    WBPaper00043978
    WBPaper00044992
    WBPaper00045173
    WBPaper00045457
    WBPaper00045618
    WBPaper00046903
    WBPaper00048228
    WBPaper00048254
    WBPaper00049573
    WBPaper00049965
    WBPaper00050384
    WBPaper00052353
    WBPaper00053705
    WBPaper00053821
    WBPaper00055090
    WBPaper00055505
    WBPaper00056045
    WBPaper00056062
    WBPaper00057900
    WBPaper00057905
    WBPaper00059280
    WBPaper00059392
    WBPaper00060130
    WBPaper00060526
    WBPaper00060545
    WBPaper00061889
    WBPaper00061898
    WBPaper00063457
    WBPaper00065011
    WBPaper00065284
    WBPaper00066042
  Remark: sequence connection from [Bernstein M, Wickens MP]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene