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WormBase Tree Display for Gene: WBGene00000858

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Name Class

WBGene00000858SMapS_parentSequenceW01B6
IdentityVersion1
NameCGC_namecwn-2Person_evidenceWBPerson1157
Sequence_nameW01B6.1
Molecular_nameW01B6.1
W01B6.1.1
CE03753
Other_nameWnt-2
CELE_W01B6.1Accession_evidenceNDBBX284604
Public_namecwn-2
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcwn
Allele (30)
Legacy_information[C.elegansII] NMK. 1.5 kb transcript, most abundant in embryo, encodes predicted 362 aa Wnt homolog. [Shackleford et al. 1993; CF]
[Shivakumar S, Jongeward G] C. elegans wnt homolog. originally isolated as cm9h7. Accession number cwn-2 mRNA X72943
Strain (21)
RNASeq_FPKM (74)
GO_annotation (66)
OrthologWBGene00065634Caenorhabditis remaneiFrom_analysisOMA
TreeFam
WormBase-Compara
WBGene00026290Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
WormBase-Compara
WBGene00146345Caenorhabditis brenneriFrom_analysisOMA
TreeFam
WormBase-Compara
WBGene00126568Caenorhabditis japonicaFrom_analysisOMA
TreeFam
WormBase-Compara
WBGene00226361Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g11512Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g13223Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g18699Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g2559Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g22123Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g3177Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g2351Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g3373Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g5865Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g13069Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00229.g7440Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-cwn-2Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold585.g4806Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00074.g3418Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_20970Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_014391Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g05457Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g11366Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_40255600Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrIV_pilon.g11492Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00073720Caenorhabditis remaneiFrom_analysisWormBase-Compara
WBGene00084163Caenorhabditis remaneiFrom_analysisWormBase-Compara
WBGene00241635Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00195118Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00266545Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00292274Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0010194Drosophila melanogasterFrom_analysisEnsEMBL-Compara
OrthoFinder
Panther
PhylomeDB
FB:FBgn0004360Drosophila melanogasterFrom_analysisInparanoid
OrthoInspector
SonicParanoid
ZFIN:ZDB-GENE-980526-87Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-030717-2Danio rerioFrom_analysisEnsEMBL-Compara
OrthoInspector
SonicParanoid
ZFIN:ZDB-GENE-060824-6Danio rerioFrom_analysisEnsEMBL-Compara
OrthoInspector
SonicParanoid
ZFIN:ZDB-GENE-060328-3Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:12784Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:12781Homo sapiensFrom_analysisEnsEMBL-Compara
OMA
OrthoInspector
SonicParanoid
HGNC:16265Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:1261834Mus musculusFrom_analysisEnsEMBL-Compara
OrthoInspector
SonicParanoid
MGI:98958Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:98959Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:98962Mus musculusFrom_analysisEnsEMBL-Compara
OrthoInspector
SonicParanoid
RGD:69250Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:69346Rattus norvegicusFrom_analysisEnsEMBL-Compara
OrthoInspector
SonicParanoid
RGD:628850Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1311441Rattus norvegicusFrom_analysisEnsEMBL-Compara
OrthoInspector
SonicParanoid
ParalogWBGene00000857Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003029Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001188Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003395Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
Structured_descriptionConcise_descriptioncwn-2 encodes one of five C. elegans Wnt signaling molecules that is homologous to mammalian Wnt5; cwn-2 is required for proper placement of the nerve ring and anterior cells along the anterior/posterior axis; cwn-2 also acts redundantly to specify cell fates during vulval development; CWN-2 appears to be required at the time of nerve ring development (comma stage of embryogenesis) for nerve ring placement and likely functions as a signaling ligand for receptors, such as CAM-1, that regulate axon guidance of the SIA and SIB neurons that plays a role in nerve ring placement; CWN-2, along with LIN-17, CAM-1, and DSH-1, functions as part of a Wnt signaling pathway that regulates ACR-16 localization to postsynaptic regions, a key component of activity-dependent synaptic plasticity; in embryos at the comma stage, a cwn-2::gfp reporter is expressed in the intestine and in pharyngeal muscle; in larvae and adults, cwn-2::gfp is seen in the intestine, pharynx, anterior body wall muscle, vulva and SMD head neurons.Paper_evidenceWBPaper00024383
WBPaper00027140
WBPaper00028436
WBPaper00035405
WBPaper00040939
Curator_confirmedWBPerson48
WBPerson1843
Date_last_updated17 Apr 2012 00:00:00
Automated_descriptionPredicted to enable cytokine activity and frizzled binding activity. Involved in several processes, including neuroblast migration; neuron migration; and pattern specification process. Predicted to be located in extracellular space. Expressed in several structures, including P5.ppp; P7.paa; RME; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant Robinow syndrome 1; endometrial carcinoma; and germ cell cancer (multiple). Is an ortholog of human WNT5A (Wnt family member 5A) and WNT5B (Wnt family member 5B).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:2871Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12784)
DOID:1911Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12781)
DOID:0060766Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12784)
DOID:3307Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12781)
DOID:127Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:16265)
DOID:0060774Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12781)
Molecular_infoCorresponding_CDSW01B6.1
Corresponding_transcriptW01B6.1.1
Other_sequence (34)
Associated_featureWBsf660548
WBsf997547
WBsf997548
WBsf1018041
WBsf1018042
WBsf228924
Experimental_infoRNAi_result (18)
Expr_pattern (16)
Drives_constructWBCnstr00008331
WBCnstr00008344
WBCnstr00008345
WBCnstr00013048
WBCnstr00014376
WBCnstr00016102
WBCnstr00016625
WBCnstr00016626
WBCnstr00016627
WBCnstr00018202
WBCnstr00018232
WBCnstr00019088
WBCnstr00020125
WBCnstr00037245
WBCnstr00040138
WBCnstr00042482
Construct_product (15)
Microarray_results (24)
Expression_cluster (144)
Interaction (134)
Anatomy_functionWBbtf0799
WBbtf0800
WBbtf0801
WBProcessWBbiopr:00000023
WBbiopr:00000073
Map_infoMapIVPosition4.48175Error0.001015
PositivePositive_cloneB0555
W01B6Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (80)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene