x12 : slightly long uncoordinated mild twitcher phenotype grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. NA3 (x1 : twitcher e1724 : lethal).
See also e1724
[Williams BD] Pat (paralysed arrest at two-fold), severe paralysis; st577 and st566 have some pharyngeal pumping.
[C.elegansII] x12 : slightly long, uncoordinated, mild twitcher phenotype; grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. OA6: x1 (twitcher), e1724 (lethal). Also Pat (paralysed arrest at two-fold) alleles: st536 (severe paralysis),st577, st566 (some pharyngeal pumping. Greatly reduced staining for tropomyosin, probably corresponds to structural gene tmy-1. [Lewis et al. 1980; Williams and Waterston 1994; HK; ZZ]lfeLet-23 FErtility effector/regulator.PS.
[C.elegansII] Probably corresponds to lev-11. Three transcripts encoding tropomyosin, probable body wall and non-muscle isoforms (284 aa,different C-termini) and pharyngeal isoform (256 aa, different promoter). [Kagawa et al. 1995; HK]
lev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line.
Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including congenital myopathy (multiple); distal arthrogryposis type 1A; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3).