rict-1 enocdes the C. elegans ortholog of mammalian Rictor, a component of the target of rapamycin complex 2 (TORC2); in C. elegans, rict-1 activity is required for regulation of fat metabolism, feeding, growth, and life span; rict-1 has been reported to interact genetically with akt-1, akt-2, and sgk-1; a rict-1::RFP promoter fusion indicates that rict-1 is expressed in head neurons, the ventral nerve cord, the intestine, body wall muscle, pharynx, and spermatheca.
Predicted to enable protein serine/threonine kinase activator activity. Involved in mesendoderm development. Part of TORC2 complex. Expressed in several structures, including head neurons; intestine; pharynx; spermatheca; and ventral nerve cord. Human ortholog(s) of this gene implicated in breast ductal carcinoma; gastrointestinal system cancer (multiple); and lung disease (multiple). Is an ortholog of human RICTOR (RPTOR independent companion of MTOR complex 2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.