WormBase Tree Display for Gene: WBGene00006887

WBGene00006887 SMap: S_parent: Sequence: C35B8
  Identity: Version: 1
    Name: CGC_name: vav-1 Person_evidence: WBPerson404
      Sequence_name: C35B8.2
      Molecular_name: C35B8.2a
        C35B8.2a.1
        CE38040
        C35B8.2b
        CE39333
        C35B8.2c
        CE53342
        C35B8.2b.1
        C35B8.2c.1
      Other_name: CELE_C35B8.2 Accession_evidence: NDB BX284606
      Public_name: vav-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: vav
    Allele: WBVar00000113
      WBVar00512380
      WBVar01172771
      WBVar01172772
      WBVar00512381
      WBVar02045173
      WBVar01172773
      WBVar00512382
      WBVar02027242
      WBVar01172774
      WBVar02027243
      WBVar00512383
      WBVar01941501
      WBVar01941502
      WBVar00512384
      WBVar01172775
      WBVar00512385
      WBVar01172776
      WBVar02074528
      WBVar01172777
      WBVar00512386
      WBVar01172778
      WBVar00512387
      WBVar01172779
      WBVar00512388
      WBVar01172780
      WBVar00512389
      WBVar00512390
      WBVar01172781
      WBVar00512391
      WBVar01172782
      WBVar01172783
      WBVar00512392
      WBVar00512393
      WBVar01172784
      WBVar01927892
      WBVar00512394
      WBVar01172785
      WBVar01172786
      WBVar01927893
      WBVar00512395
      WBVar00512396
      WBVar01172787
      WBVar01927894
      WBVar01172788
      WBVar00512397
      WBVar01172789
      WBVar00512398
      WBVar00512399
      WBVar01172790
      WBVar01172791
      WBVar00512400
      WBVar00512401
      WBVar01172792
      WBVar00512402
      WBVar01172793
      WBVar01172794
      WBVar01172795
      WBVar01954493
      WBVar01172796
      WBVar01172797
      WBVar01172798
      WBVar01172799
      WBVar02116579
      WBVar01172801
      WBVar01172802
      WBVar01816588
      WBVar01172803
      WBVar01172804
      WBVar01172805
      WBVar01172806
      WBVar01172807
      WBVar01172808
      WBVar01172809
      WBVar01172810
      WBVar02139825
      WBVar01172811
      WBVar01172812
      WBVar01172813
      WBVar01470420
      WBVar01172814
      WBVar01470421
      WBVar01172815
      WBVar01470422
      WBVar01172816
      WBVar01172817
      WBVar01470423
      WBVar01470424
      WBVar01172818
      WBVar01470425
      WBVar01172819
      WBVar01172820
      WBVar01470426
      WBVar01470427
      WBVar01470428
      WBVar01470429
      WBVar00057975
      WBVar00057985
      WBVar00057990
      WBVar00057995
      WBVar00058000
      WBVar00058005
      WBVar01758864
      WBVar01758865
      WBVar01758866
      WBVar01499036
      WBVar01499037
      WBVar01758867
      WBVar01758868
      WBVar00058015
      WBVar01654849
      WBVar01487449
      WBVar01499963
      WBVar01487450
      WBVar01619635
      WBVar01602090
      WBVar01619636
      WBVar01619637
      WBVar01619638
      WBVar00058035
      WBVar01619639
      WBVar00058040
      WBVar01544525
      WBVar00058045
      WBVar01886879
      WBVar01886880
      WBVar01886881
      WBVar00254596
      WBVar01886882
      WBVar01886883
      WBVar01886884
      WBVar01527334
      WBVar01886885
      WBVar01886886
      WBVar01527335
      WBVar01527336
      WBVar01886887
      WBVar01527337
      WBVar01886888
      WBVar01886889
      WBVar01886890
      WBVar01886891
      WBVar01886892
      WBVar01886893
      WBVar00091719
      WBVar00258659
      WBVar01886894
      WBVar01886895
      WBVar01886896
      WBVar01886897
      WBVar01886898
      WBVar00249450
      WBVar01172710
      WBVar01987438
      WBVar01172711
      WBVar01987439
      WBVar01987440
      WBVar01172712
      WBVar01499642
      WBVar01172713
      WBVar01172714
      WBVar01172715
      WBVar01172716
      WBVar01172717
      WBVar01172718
      WBVar01172719
      WBVar02065523
      WBVar01172720
      WBVar02065524
      WBVar01172721
      WBVar02065525
      WBVar02065526
      WBVar01172722
      WBVar01493762
      WBVar00081836
      WBVar02065527
      WBVar01172723
      WBVar00081838
      WBVar01172724
      WBVar02065528
      WBVar02065529
      WBVar00081839
      WBVar01172725
      WBVar01172726
      WBVar02065530
      WBVar00081840
      WBVar01172727
      WBVar01172728
      WBVar01172729
      WBVar01172730
      WBVar01172731
      WBVar01945795
      WBVar01172732
      WBVar01172733
      WBVar01945796
      WBVar01172734
      WBVar01945797
      WBVar01172735
      WBVar01172736
      WBVar01172737
      WBVar01172738
      WBVar01172739
      WBVar01172740
      WBVar01172741
      WBVar01172742
      WBVar02047769
      WBVar01172743
      WBVar01172744
      WBVar01172745
      WBVar01172746
      WBVar01172747
      WBVar01172748
      WBVar01172749
      WBVar01981169
      WBVar01172750
      WBVar01172751
      WBVar01172752
      WBVar01172753
      WBVar01172754
      WBVar00512364
      WBVar01550907
      WBVar01172755
      WBVar01550908
      WBVar00512365
      WBVar01172756
      WBVar00512366
      WBVar01172757
      WBVar01550909
      WBVar01550910
      WBVar01172758
      WBVar00512367
      WBVar00512368
      WBVar01172759
      WBVar01172760
      WBVar00512369
      WBVar01172761
      WBVar00099544
      WBVar00512370
      WBVar01172762
      WBVar00512371
      WBVar00512372
      WBVar01172763
      WBVar00512373
      WBVar01172764
      WBVar00512374
      WBVar01172765
      WBVar01172766
      WBVar00512375
      WBVar00512376
      WBVar01172767
      WBVar01498960
      WBVar00512377
      WBVar01172768
      WBVar01172769
      WBVar00512378
      WBVar01500067
      WBVar01172770
      WBVar00512379
    Strain: WBStrain00003320
      WBStrain00035617
    RNASeq_FPKM (74)
    GO_annotation: 00003931
      00003932
      00080791
      00080792
      00080793
      00080794
      00080795
      00080796
      00080797
      00114965
    Ortholog (48)
    Paralog: WBGene00006496 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006805 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00009337 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00010111 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00010776 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00015704 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: vav-1 encodes a Rho/Rac-family guanine nucleotide exchange factor orthologous to the Vav proto-oncogene; VAV-1 is a complex protein with several domains, from N- to C-terminus: a calponin-like actin-binding domain; a RhoGEF/DH domain; a pleckstrin-like domain; a SH2 motif domain; and an SH3 domain; in C. elegans vav-1 is an essential gene and functions to regulate the concentration of intracellular calcium and thus, plays a key role in regulating rhythmic behaviors such as pharyngeal pumping, ovulation, and defecation; in addition, vav-1 has been shown to be a target of the mir-61 miRNA in the secondary vulval precursor cells, where it functions to negatively regulate LIN-12 activity; VAV-1::GFP reporters are expressed in the pharynx, the contractile sheath cells of the gonad, the four posterior-most intestinal cells, and the three rectal epithelial cells; VAV-1::GFP is also seen in the distal gonad, body wall muscle, and in the vulval precursor cells and their descendants. Paper_evidence: WBPaper00012852
            WBPaper00026850
            WBPaper00026909
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 20 Feb 2009 00:00:00
      Automated_description: Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of Notch signaling pathway; positive regulation of nematode male tail tip morphogenesis; and regulation of vulval development. Predicted to be located in cytoplasm. Expressed in several structures, including gonad; intestinal cell; neurons; pharyngeal cell; and tail hypodermis. Is an ortholog of human VAV1 (vav guanine nucleotide exchange factor 1); VAV2 (vav guanine nucleotide exchange factor 2); and VAV3 (vav guanine nucleotide exchange factor 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C35B8.2a
      C35B8.2b
      C35B8.2c
    Corresponding_CDS_history: C35B8.2:wp129
      C35B8.2:wp138
      C35B8.2:wp151
      C35B8.2b:wp271
    Corresponding_transcript: C35B8.2a.1
      C35B8.2b.1
      C35B8.2c.1
    Other_sequence (24)
    Associated_feature (16)
  Experimental_info: RNAi_result (17)
    Expr_pattern (13)
    Drives_construct: WBCnstr00000019
      WBCnstr00003791
      WBCnstr00008160
      WBCnstr00011643
      WBCnstr00011704
      WBCnstr00020222
      WBCnstr00034113
    Construct_product: WBCnstr00000018
      WBCnstr00000019
      WBCnstr00000020
      WBCnstr00000027
      WBCnstr00011643
      WBCnstr00014782
      WBCnstr00019921
      WBCnstr00019932
      WBCnstr00020222
      WBCnstr00034113
    Microarray_results (26)
    Expression_cluster (106)
    Interaction (113)
    WBProcess: WBbiopr:00000044
      WBbiopr:00000053
      WBbiopr:00000120
  Map_info (4)
  Reference (27)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene