WormBase Tree Display for Gene: WBGene00003058

WBGene00003058 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 1
    Name: CGC_name: lov-1 Person_evidence: WBPerson625
      Sequence_name: ZK945.9
      Molecular_name: ZK945.9
        ZK945.9.1
        CE45696
      Other_name: pkd-1
        CELE_ZK945.9 Accession_evidence: NDB BX284602
      Public_name: lov-1
    DB_info: Database: AceView gene 2K400
        WormQTL gene WBGene00003058
        WormFlux gene WBGene00003058
        OMIM disease 173900
            601313
        NDB locus_tag CELE_ZK945.9
        Panther gene CAEEL|WormBase=WBGene00003058|UniProtKB=Q09624
          family PTHR10877
        NCBI gene 174576
        RefSeq protein NM_063783.4
        SwissProt UniProtAcc Q09624
        UniProt_GCRP UniProtAcc Q09624
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lov
    Allele: WBVar00249009 Inferred_automatically: From strain object: PS3151
      WBVar00249016 Inferred_automatically: From strain object: PS3398
          From strain object: PS3401
      WBVar02147221
      WBVar00145129
      WBVar01499702
      WBVar00760455
      WBVar01498798
      WBVar00091809
      WBVar00253409
      WBVar00760456
      WBVar00760457
      WBVar00760458
      WBVar00760459
      WBVar00760460
      WBVar01498435
      WBVar00760461
      WBVar01496964
      WBVar00760462
      WBVar00760463
      WBVar00760464
      WBVar00760465
      WBVar00760466
      WBVar00760467
      WBVar00760468
      WBVar00760469
      WBVar00760470
      WBVar00760471
      WBVar00760472
      WBVar00760473
      WBVar02130589
      WBVar00760474
      WBVar02130590
      WBVar00760475
      WBVar00760476
      WBVar00760477
      WBVar00760478
      WBVar00760479
      WBVar00760480
      WBVar00760481
      WBVar00760482
      WBVar00760483
      WBVar00760484
      WBVar00760485
      WBVar00760486
      WBVar00760487
      WBVar00760488
      WBVar00760489
      WBVar00760490
      WBVar01960203
      WBVar01655379
      WBVar00760491
      WBVar00760492
      WBVar00760493
      WBVar00760494
      WBVar01439350
      WBVar00760495
      WBVar01627155
      WBVar00760496
      WBVar00760497
      WBVar01627156
      WBVar01720522
      WBVar00760498
      WBVar01627157
      WBVar01477865
      WBVar01720523
      WBVar00760499
      WBVar00760500
      WBVar00760501
      WBVar00760502
      WBVar00760503
      WBVar00760504
      WBVar00760505
      WBVar00760506
      WBVar00174914
      WBVar00174915
      WBVar00760507
      WBVar00760508
      WBVar00174916
      WBVar00174917
      WBVar00760509
      WBVar00760510
      WBVar00760511
      WBVar01538534
      WBVar00760512
      WBVar00760513
      WBVar00760514
      WBVar00760515
      WBVar00760516
      WBVar01413843
      WBVar01546723
      WBVar00760517
      WBVar00760518
      WBVar01546724
      WBVar00760519
      WBVar00265989
      WBVar00760520
      WBVar00760521
      WBVar00760522
      WBVar00760523
      WBVar02150382
      WBVar00760524
      WBVar00760525
      WBVar00760526
      WBVar00760527
      WBVar00760528
      WBVar02014335
      WBVar00760529
      WBVar00760530
      WBVar00760531
      WBVar00760532
      WBVar00760533
      WBVar00760534
      WBVar00760535
      WBVar00760536
      WBVar00760537
      WBVar00760538
      WBVar00760539
      WBVar00760540
      WBVar00760541
      WBVar01935345
      WBVar00760542
      WBVar01499260
      WBVar02146252
      WBVar02040465
      WBVar01488611
      WBVar01685358
      WBVar00238503
      WBVar01405529
      WBVar00375456
      WBVar00375457
      WBVar00375458
      WBVar00375459
      WBVar00375460
      WBVar01498940
      WBVar00375461
      WBVar00375462
      WBVar00375463
      WBVar00375464
      WBVar01310587
      WBVar00375465
      WBVar01310588
      WBVar00375466
      WBVar01310589
      WBVar01310591
      WBVar00375467
      WBVar01310592
      WBVar01499132
      WBVar00375468
      WBVar00375469
      WBVar01310593
      WBVar01310594
      WBVar00375470
      WBVar01500238
      WBVar01310595
      WBVar00375471
      WBVar00375472
      WBVar01310598
      WBVar01243711
      WBVar01310599
      WBVar00375473
      WBVar01310600
      WBVar00228195
      WBVar00375474
      WBVar01243712
      WBVar01310601
      WBVar00375475
      WBVar01666587
      WBVar00228196
      WBVar01243713
      WBVar01243714
      WBVar00228197
      WBVar00375476
      WBVar01243715
      WBVar00228198
      WBVar00375477
      WBVar01243717
      WBVar00375478
      WBVar00375479
      WBVar00228201
      WBVar00375480
      WBVar01243719
      WBVar01243721
      WBVar00314580
    Strain: WBStrain00030878
      WBStrain00030885
      WBStrain00030886
      WBStrain00031467
    RNASeq_FPKM (74)
    GO_annotation (34)
    Ortholog (27)
    Paralog: WBGene00004035 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00016889 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description (2)
  Disease_info: Experimental_model: DOID:898 Homo sapiens Paper_evidence: WBPaper00003680
            WBPaper00004854
          Accession_evidence: OMIM 173900
          Curator_confirmed: WBPerson324
          Date_last_updated: 30 Apr 2018 00:00:00
    Disease_relevance: lov-1 and pkd-2 encode the orthologs of human Polycystin-1 and Polycystin-2, which are mutated in autosomal dominant polycystic kidney disease; the polycystins regulate signaling involved in normal renal tubular structure and function; studies in the worm C. elegans have contributed extensively to the finding that cystic kidney diseases can be considered ciliopathies; in elegans lov-1 and pkd-2 are expressed in male ciliary neurons, are required for normal male mating behavior, do not seem to be required for ciliogenesis, and each polycystin may actually have a potential inhibitory function on the other for ciliary function; lov-1 and pkd-1 interact with a single-pass transmembrane protein, CWP-5, though the significance of this interaction for polycystic kidney disease is unknown. Homo sapiens Paper_evidence: WBPaper00003680
          Accession_evidence: OMIM 601313
              173900
          Curator_confirmed: WBPerson324
          Date_last_updated: 31 Jan 2013 00:00:00
  Models_disease_asserted: WBDOannot00000024
    WBDOannot00000512
    WBDOannot00000515
    WBDOannot00000516
  Molecular_info: Corresponding_CDS: ZK945.9
    Corresponding_CDS_history: ZK945.9:wp188
      ZK945.9:wp222
    Corresponding_transcript: ZK945.9.1
    Other_sequence: JI173898.1
      JO470013.1
      JO468300.1
      JI164556.1
    Associated_feature: WBsf989248
      WBsf1012968
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr1148
      Expr3208
      Expr11946
      Expr1025218
      Expr1163281
      Expr2013249
      Expr2031480
    Drives_construct: WBCnstr00006717
      WBCnstr00010107
      WBCnstr00014864
      WBCnstr00014875
      WBCnstr00019759
      WBCnstr00019881
      WBCnstr00036257
    Construct_product: WBCnstr00014869
      WBCnstr00014875
      WBCnstr00019759
      WBCnstr00036257
    Antibody: WBAntibody00002515
      WBAntibody00002632
    Microarray_results (22)
    Expression_cluster (64)
    Interaction (58)
    WBProcess: WBbiopr:00000012
  Map_info: Map: II Position: 1.90347 Error: 0.014559
    Well_ordered
    Positive: Positive_clone: ZK945 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3960
        3961
        5093
      Pos_neg_data: 10577
        10578
        10579
        10580
        10581
        10582
  Reference (101)
  Method: Gene