WormBase Tree Display for Gene: WBGene00003003
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WBGene00003003 | SMap | S_parent | Sequence | T25C12 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | lin-14 | Person_evidence | WBPerson261 | |||||
Sequence_name | T25C12.1 | ||||||||
Molecular_name | T25C12.1a | ||||||||
T25C12.1a.1 | |||||||||
CE43285 | |||||||||
T25C12.1b | |||||||||
CE03734 | |||||||||
T25C12.1b.1 | |||||||||
Other_name | CELE_T25C12.1 | Accession_evidence | NDB | BX284606 | |||||
Public_name | lin-14 | ||||||||
DB_info | Database | AceView | gene | XM103 | |||||
WormQTL | gene | WBGene00003003 | |||||||
WormFlux | gene | WBGene00003003 | |||||||
NDB | locus_tag | CELE_T25C12.1 | |||||||
NCBI | gene | 181337 | |||||||
RefSeq | protein | NM_077515.5 | |||||||
NM_077516.7 | |||||||||
SwissProt | UniProtAcc | Q21446 | |||||||
TREEFAM | TREEFAM_ID | TF316913 | |||||||
UniProt_GCRP | UniProtAcc | Q21446 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | lin | ||||||||
Reference_allele | WBVar00089301 | ||||||||
WBVar00089587 | |||||||||
Allele | WBVar00089450 | Inferred_automatically | From strain object: MT1848 | ||||||
From strain object: MT862 | |||||||||
WBVar00089496 | Inferred_automatically | From strain object: MT925 | |||||||
WBVar00088773 | Inferred_automatically | From strain object: VT284 | |||||||
WBVar00089447 | |||||||||
WBVar00089448 | |||||||||
WBVar00089592 | |||||||||
WBVar00089446 | |||||||||
WBVar00089449 | |||||||||
WBVar00275046 | |||||||||
WBVar00089709 | |||||||||
WBVar00275050 | |||||||||
WBVar00089589 | |||||||||
WBVar00089801 | |||||||||
WBVar00143283 | |||||||||
WBVar00089584 | |||||||||
WBVar00089799 | |||||||||
WBVar00089586 | |||||||||
WBVar00275051 | |||||||||
WBVar00089802 | |||||||||
WBVar00089588 | |||||||||
WBVar00089590 | |||||||||
WBVar00089797 | |||||||||
WBVar00275047 | |||||||||
WBVar00275043 | |||||||||
WBVar02153550 | |||||||||
WBVar02157624 | |||||||||
WBVar02157626 | |||||||||
WBVar02157627 | |||||||||
WBVar02157628 | |||||||||
WBVar01188254 | |||||||||
WBVar00300565 | |||||||||
WBVar01188255 | |||||||||
WBVar01188256 | |||||||||
WBVar02112319 | |||||||||
WBVar02027426 | |||||||||
WBVar01499887 | |||||||||
WBVar01188257 | |||||||||
WBVar02027427 | |||||||||
WBVar01188258 | |||||||||
WBVar01499888 | |||||||||
WBVar01602195 | |||||||||
WBVar01188259 | |||||||||
WBVar01602196 | |||||||||
WBVar01188260 | |||||||||
WBVar01602197 | |||||||||
WBVar01188261 | |||||||||
WBVar01188262 | |||||||||
WBVar01188263 | |||||||||
WBVar01499710 | |||||||||
WBVar01188264 | |||||||||
WBVar01897932 | |||||||||
WBVar01188265 | |||||||||
WBVar01897933 | |||||||||
WBVar01188266 | |||||||||
WBVar02032861 | |||||||||
WBVar01188267 | |||||||||
WBVar00274531 | |||||||||
WBVar01188268 | |||||||||
WBVar00274533 | |||||||||
WBVar00260216 | |||||||||
WBVar00089301 | |||||||||
WBVar01987711 | |||||||||
WBVar01987712 | |||||||||
WBVar02072669 | |||||||||
WBVar01987713 | |||||||||
WBVar02068023 | |||||||||
WBVar01987714 | |||||||||
WBVar01489247 | |||||||||
WBVar00601538 | |||||||||
WBVar01188114 | |||||||||
WBVar01188115 | |||||||||
WBVar01188116 | |||||||||
WBVar01188117 | |||||||||
WBVar01188118 | |||||||||
WBVar00089445 | |||||||||
WBVar01188119 | |||||||||
WBVar01188120 | |||||||||
WBVar01188121 | |||||||||
WBVar01188123 | |||||||||
WBVar01188124 | |||||||||
WBVar01188125 | |||||||||
WBVar01188126 | |||||||||
WBVar01188127 | |||||||||
WBVar01188128 | |||||||||
WBVar01188129 | |||||||||
WBVar01188130 | |||||||||
WBVar01188131 | |||||||||
WBVar01188132 | |||||||||
WBVar01188133 | |||||||||
WBVar01188134 | |||||||||
WBVar01188135 | |||||||||
WBVar01188136 | |||||||||
WBVar01188137 | |||||||||
WBVar01188138 | |||||||||
WBVar02152597 | |||||||||
WBVar01188139 | |||||||||
WBVar01188140 | |||||||||
WBVar01188141 | |||||||||
WBVar02009144 | |||||||||
WBVar01188142 | |||||||||
WBVar02009145 | |||||||||
WBVar01188143 | |||||||||
WBVar02009146 | |||||||||
WBVar01188144 | |||||||||
WBVar01188145 | |||||||||
WBVar01188146 | |||||||||
WBVar02093439 | |||||||||
WBVar01188147 | |||||||||
WBVar01188148 | |||||||||
WBVar01188149 | |||||||||
WBVar01188150 | |||||||||
WBVar01188151 | |||||||||
WBVar01188152 | |||||||||
WBVar01188153 | |||||||||
WBVar01188154 | |||||||||
WBVar01498128 | |||||||||
WBVar01188155 | |||||||||
WBVar01188156 | |||||||||
WBVar01188157 | |||||||||
WBVar00089582 | |||||||||
WBVar01188158 | |||||||||
WBVar00089583 | |||||||||
WBVar01188159 | |||||||||
WBVar00089585 | |||||||||
WBVar00089587 | |||||||||
WBVar01188160 | |||||||||
WBVar01497582 | |||||||||
WBVar01188161 | |||||||||
WBVar00089591 | |||||||||
WBVar01188162 | |||||||||
WBVar00089593 | |||||||||
WBVar00083186 | |||||||||
WBVar00089594 | |||||||||
WBVar01188163 | |||||||||
WBVar00083187 | |||||||||
WBVar01703416 | |||||||||
WBVar01494274 | |||||||||
WBVar01188164 | |||||||||
WBVar01188165 | |||||||||
WBVar00083188 | |||||||||
WBVar01703417 | |||||||||
WBVar01820533 | |||||||||
WBVar01188166 | |||||||||
WBVar00083189 | |||||||||
WBVar01188167 | |||||||||
WBVar00083190 | |||||||||
WBVar01188168 | |||||||||
WBVar00083191 | |||||||||
WBVar01493175 | |||||||||
WBVar01188169 | |||||||||
WBVar00083192 | |||||||||
WBVar01188170 | |||||||||
WBVar00083193 | |||||||||
WBVar00083194 | |||||||||
WBVar01188171 | |||||||||
WBVar00083195 | |||||||||
WBVar01188172 | |||||||||
WBVar01188173 | |||||||||
WBVar01188174 | |||||||||
WBVar01188175 | |||||||||
WBVar01188176 | |||||||||
WBVar01188177 | |||||||||
WBVar01188178 | |||||||||
WBVar01690508 | |||||||||
WBVar01188179 | |||||||||
WBVar01690509 | |||||||||
WBVar01188180 | |||||||||
WBVar01188181 | |||||||||
WBVar01690510 | |||||||||
WBVar01188182 | |||||||||
WBVar01690511 | |||||||||
WBVar01690512 | |||||||||
WBVar01188183 | |||||||||
WBVar01690513 | |||||||||
WBVar01188185 | |||||||||
WBVar01620587 | |||||||||
WBVar01188186 | |||||||||
WBVar01620588 | |||||||||
WBVar01500001 | |||||||||
WBVar01620589 | |||||||||
WBVar01188187 | |||||||||
WBVar01620590 | |||||||||
WBVar01500002 | |||||||||
WBVar01188188 | |||||||||
WBVar01188189 | |||||||||
WBVar01188190 | |||||||||
WBVar01188191 | |||||||||
WBVar00089668 | |||||||||
WBVar01188192 | |||||||||
WBVar01188193 | |||||||||
WBVar01759469 | |||||||||
WBVar01759470 | |||||||||
WBVar01188194 | |||||||||
WBVar01188195 | |||||||||
WBVar01759471 | |||||||||
WBVar01188196 | |||||||||
WBVar01487681 | |||||||||
WBVar01759472 | |||||||||
WBVar02051082 | |||||||||
WBVar01188197 | |||||||||
WBVar00517475 | |||||||||
WBVar00517476 | |||||||||
WBVar01188198 | |||||||||
WBVar02051083 | |||||||||
WBVar00517477 | |||||||||
WBVar01188199 | |||||||||
WBVar01188200 | |||||||||
WBVar00517478 | |||||||||
WBVar00517479 | |||||||||
WBVar01188201 | |||||||||
WBVar01188202 | |||||||||
WBVar00517480 | |||||||||
WBVar00517481 | |||||||||
WBVar01188203 | |||||||||
WBVar01188204 | |||||||||
WBVar00517482 | |||||||||
WBVar00517483 | |||||||||
WBVar01188205 | |||||||||
WBVar00089710 | |||||||||
WBVar01188206 | |||||||||
WBVar00517484 | |||||||||
WBVar00517485 | |||||||||
WBVar01188207 | |||||||||
WBVar01188208 | |||||||||
WBVar00517486 | |||||||||
WBVar01825919 | |||||||||
WBVar01188209 | |||||||||
WBVar00517487 | |||||||||
WBVar00517488 | |||||||||
WBVar01188210 | |||||||||
WBVar01188211 | |||||||||
WBVar00517489 | |||||||||
WBVar01188212 | |||||||||
WBVar00517490 | |||||||||
WBVar00517491 | |||||||||
WBVar01188213 | |||||||||
WBVar01981336 | |||||||||
WBVar00517492 | |||||||||
WBVar01188214 | |||||||||
WBVar01981337 | |||||||||
WBVar00517493 | |||||||||
WBVar01188215 | |||||||||
WBVar00517494 | |||||||||
WBVar01981338 | |||||||||
WBVar01188216 | |||||||||
WBVar01981339 | |||||||||
WBVar01188217 | |||||||||
WBVar00517495 | |||||||||
WBVar01981340 | |||||||||
WBVar01188218 | |||||||||
WBVar00517496 | |||||||||
WBVar01188219 | |||||||||
WBVar01981341 | |||||||||
WBVar00517497 | |||||||||
WBVar00517498 | |||||||||
WBVar02140121 | |||||||||
WBVar01188220 | |||||||||
WBVar00517499 | |||||||||
WBVar02140122 | |||||||||
WBVar01188221 | |||||||||
WBVar01188222 | |||||||||
WBVar02140123 | |||||||||
WBVar00517500 | |||||||||
WBVar01188223 | |||||||||
WBVar00517501 | |||||||||
WBVar01188224 | |||||||||
WBVar01787034 | |||||||||
WBVar00517502 | |||||||||
WBVar01188225 | |||||||||
WBVar00517503 | |||||||||
WBVar00517504 | |||||||||
WBVar01188226 | |||||||||
WBVar00517505 | |||||||||
WBVar01471181 | |||||||||
WBVar01188227 | |||||||||
WBVar00517506 | |||||||||
WBVar01188228 | |||||||||
WBVar01471182 | |||||||||
WBVar01188229 | |||||||||
WBVar00517507 | |||||||||
WBVar01471183 | |||||||||
WBVar00517508 | |||||||||
WBVar01471184 | |||||||||
WBVar01493787 | |||||||||
WBVar01188230 | |||||||||
WBVar01471185 | |||||||||
WBVar01188231 | |||||||||
WBVar00517509 | |||||||||
WBVar01493788 | |||||||||
WBVar01471186 | |||||||||
WBVar00517510 | |||||||||
WBVar01188232 | |||||||||
WBVar01188233 | |||||||||
WBVar01471187 | |||||||||
WBVar00517511 | |||||||||
WBVar01188234 | |||||||||
WBVar01471188 | |||||||||
WBVar00517512 | |||||||||
WBVar01188235 | |||||||||
WBVar01471189 | |||||||||
WBVar00517513 | |||||||||
WBVar00089798 | |||||||||
WBVar00517514 | |||||||||
WBVar01188236 | |||||||||
WBVar01471190 | |||||||||
WBVar00089800 | |||||||||
WBVar00517515 | |||||||||
WBVar01471191 | |||||||||
WBVar01188237 | |||||||||
WBVar00517516 | |||||||||
WBVar01188238 | |||||||||
WBVar00517517 | |||||||||
WBVar01188239 | |||||||||
WBVar01188240 | |||||||||
WBVar00517518 | |||||||||
WBVar00517519 | |||||||||
WBVar01188241 | |||||||||
WBVar01188242 | |||||||||
WBVar00517520 | |||||||||
WBVar01188243 | |||||||||
WBVar00517521 | |||||||||
WBVar00517522 | |||||||||
WBVar01188244 | |||||||||
WBVar00517523 | |||||||||
WBVar01188245 | |||||||||
WBVar00517524 | |||||||||
WBVar01188246 | |||||||||
WBVar01188247 | |||||||||
WBVar01188248 | |||||||||
WBVar01188249 | |||||||||
WBVar01188250 | |||||||||
WBVar01498960 | |||||||||
WBVar01188251 | |||||||||
WBVar01188252 | |||||||||
WBVar01494914 | |||||||||
WBVar01500067 | |||||||||
WBVar01188253 | |||||||||
Legacy_information | Class 1 alleles (loss-of-function) n526n540ird : precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva endoderm and mesoderm; abnormal cuticle formation; ES2; male more severely affected only three molts gonadal development abnormal. Similar phenotype in n536n540/Df. NA > 10 (n179ts etc.; also Class 1a n355n679ird ts (only early events precocious); Class 1b n360ts (only late events precocious). Class 2 alleles (gain-of-function) n536sd : retarded heterochronic alterations in many lineages abnormal vulval development cuticle formation supernumerary molts extra divisions in sex mesoblasts intestine etc.; gonadal lineages normal. ES3. ME0? NA2 (n355sd). For both Class 1 and Class 2 mutations late lineages are less affected if animal develops via dauer stage. | ||||||||
See also n179, n355, n360, n407, n530, n531, n532, n534, n535, n536, n539, n540, n679, n726, n727, n837, n838, n839, n840, n841, n842 | |||||||||
[C.elegansII] n526n540ird : lf allele (Class II, a-b-), precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva,endoderm and mesoderm; abnormal cuticle formation; precocious dauer entry at L1 molt; ES2; male more severely affected, only three molts, gonadal development abnormal. Similar phenotype in n536n540/Df. OA>10: n179ts, etc.; also n355n679ird,ts (Class V, a-b+, only early events precocious); n360ts(Class III, a+b-, only late events precocious). Also gain-of-function alleles: n536sd (Class I, retarded heterochronic alterations in many lineages; abnormal vulval development, cuticle formation, supernumerary molts, extra divisions in sex mesoblasts, intestine etc.; gonadal lineages normal. ES3), n355sd(similar). Numerous intragenic revertants. For both lf and gf mutations, late lineages are less affected if animal develops via dauer stage. Cloned: two 3.5 kb transcripts, differing 5',encoding 70 kD novel proteins; antibodies stain nuclei; protein levels high in L1, reduced or absent later. Gain-of-function mutations affect3' UTR. [Ruvkun and Giusto 1989; Wightman et al. 1993; GR; VT] | |||||||||
Strain (20) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (16) | |||||||||
Ortholog (28) | |||||||||
Structured_description | Concise_description | lin-14 encodes a novel protein whose activity is required for specifying the division timings of a specific group of cells during postembryonic development; lin-14 loss-of-function mutations result in the premature appearance of later larval lineages, while gain-of-function mutations result in reiteration of L1 larval stages lineages; in addition, lin-14 acts as a positive regulator of AVM, PVM, and FLP touch cell development; in regulating developmental timing, lin-14 acts, in part, by positively regulating the activity of lin-28, which encodes a cytoplasmic protein also required for proper developmental timing; at hatching, LIN-14 is detected in the nuclei of blast cells and neurons; later, from the late L1 to adult stages, LIN-14 levels are negatively regulated by translational repression mediated by lin-4, a 22-nt small temporal RNA (stRNA) that is complementary to sequences in the lin-14 3' UTR. | Paper_evidence | WBPaper00000620 | |||||
WBPaper00001137 | |||||||||
WBPaper00001468 | |||||||||
WBPaper00001829 | |||||||||
WBPaper00001848 | |||||||||
WBPaper00003931 | |||||||||
WBPaper00005159 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 02 Sep 2005 00:00:00 | ||||||||
Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and single-stranded DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell fate specification; and regulation of nematode larval development, heterochronic. Located in condensed nuclear chromosome. Expressed in several structures, including QL; QR; neurons; oocyte; and somatic nervous system. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info (6) | |||||||||
Experimental_info (10) | |||||||||
Map_info | Map | X | Position | 3.78431 | Error | 0.060767 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | nDf19 | |||||||
yDp8 | |||||||||
yDp10 | |||||||||
Positive_clone | PPE4 | ||||||||
T25C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Mapping_data | 2_point | 251 | |||||||
492 | |||||||||
636 | |||||||||
637 | |||||||||
688 | |||||||||
3648 | |||||||||
3652 | |||||||||
Multi_point (22) | |||||||||
Pos_neg_data | 3918 | ||||||||
3920 | |||||||||
654 | |||||||||
668 | |||||||||
3155 | |||||||||
294 | |||||||||
1831 | |||||||||
8427 | |||||||||
Reference (365) | |||||||||
Method | Gene |