WormBase Tree Display for Gene: WBGene00001650

WBGene00001650 SMap: S_parent: Sequence: CHROMOSOME_IV
  Identity: Version: 1
    Name: CGC_name: gon-1 Person_evidence: WBPerson261
      Sequence_name: F25H8.3
      Molecular_name: F25H8.3a
        F25H8.3a.1
        CE42668
        F25H8.3b
        CE46622
        F25H8.3a.2
        F25H8.3b.1
        F25H8.3c
      Other_name: CELE_F25H8.3 Accession_evidence: NDB BX284604
      Public_name: gon-1
    DB_info: Database (14)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gon
    Allele: WBVar00143863 Inferred_automatically: From strain object: CB4504
      WBVar00241148 Inferred_automatically: From strain object: JK2532
      WBVar00144872 Inferred_automatically: From strain object: JK3140
      WBVar01473911
      WBVar01473909
      WBVar00145265
      WBVar01473910
      WBVar01453805
      WBVar01453806
      WBVar00251919
      WBVar01500079
      WBVar00277258
      WBVar00934853
      WBVar01609462
      WBVar01498996
      WBVar00934854
      WBVar00934855
      WBVar00934856
      WBVar00934857
      WBVar00934858
      WBVar00934859
      WBVar00934860
      WBVar00433114
      WBVar00934861
      WBVar00433115
      WBVar00433116
      WBVar00934862
      WBVar00934863
      WBVar00433117
      WBVar01499925
      WBVar00934864
      WBVar00433118
      WBVar00433119
      WBVar00934865
      WBVar00433120
      WBVar00934866
      WBVar00934867
      WBVar00433121
      WBVar00433122
      WBVar01482265
      WBVar02114940
      WBVar00934868
      WBVar00934869
      WBVar00433123
      WBVar02134484
      WBVar00934870
      WBVar00433124
      WBVar02134485
      WBVar00256938
      WBVar00934871
      WBVar02134486
      WBVar00433125
      WBVar02134487
      WBVar00934872
      WBVar00433126
      WBVar00433127
      WBVar02134488
      WBVar00934873
      WBVar00934874
      WBVar02134489
      WBVar00433128
      WBVar00433129
      WBVar00934875
      WBVar00934876
      WBVar00602943
      WBVar00433130
      WBVar00934877
      WBVar00433131
      WBVar00934878
      WBVar00433132
      WBVar00934879
      WBVar00433133
      WBVar00433134
      WBVar00934880
      WBVar00433135
      WBVar00934881
      WBVar00433136
      WBVar00934882
      WBVar00934883
      WBVar00433137
      WBVar00934884
      WBVar00433138
      WBVar00433139
      WBVar00934885
      WBVar00934886
      WBVar00433140
      WBVar00433141
      WBVar01856454
      WBVar00934887
      WBVar01856455
      WBVar00934888
      WBVar00433142
      WBVar01856456
      WBVar00934889
      WBVar00433143
      WBVar01856457
      WBVar00934890
      WBVar00433144
      WBVar00934891
      WBVar00433145
      WBVar01856458
      WBVar00934892
      WBVar00433146
      WBVar01856459
      WBVar00433147
      WBVar00934893
      WBVar01856460
      WBVar00934894
      WBVar01856461
      WBVar01856462
      WBVar00934895
      WBVar01856463
      WBVar00934896
      WBVar01856464
      WBVar00934897
      WBVar00934898
      WBVar00934899
      WBVar00934900
      WBVar00934901
      WBVar00934902
      WBVar00934903
      WBVar00934904
      WBVar00934905
      WBVar00934906
      WBVar00934907
      WBVar01795104
      WBVar01795105
      WBVar00934908
      WBVar01795106
      WBVar00934909
      WBVar00934910
      WBVar01795107
      WBVar01795108
      WBVar00934911
      WBVar01795109
      WBVar00934912
      WBVar00934913
      WBVar00934914
      WBVar00934915
      WBVar00934916
      WBVar00934917
      WBVar00934918
      WBVar00934919
      WBVar01999838
      WBVar00934920
      WBVar00934921
      WBVar02021081
      WBVar00934922
      WBVar00934923
      WBVar00934924
      WBVar00934925
      WBVar02041961
      WBVar02103770
      WBVar00934926
      WBVar00934927
      WBVar00934928
      WBVar00934929
      WBVar00934930
      WBVar00934931
      WBVar00934932
      WBVar00934933
      WBVar00934934
      WBVar00934935
      WBVar00934936
      WBVar00934937
      WBVar00934938
      WBVar00934939
      WBVar00934940
      WBVar00191606
      WBVar00934941
      WBVar00934942
      WBVar00191607
      WBVar00191608
      WBVar02008273
      WBVar00934943
      WBVar00191609
      WBVar00934944
      WBVar00191610
      WBVar00934945
      WBVar00599619
      WBVar00191611
      WBVar00934946
      WBVar00191612
      WBVar00934947
      WBVar00934948
      WBVar00934949
      WBVar00934950
      WBVar00934951
      WBVar00934952
      WBVar00934953
      WBVar00934954
      WBVar00934955
      WBVar00934956
      WBVar00934957
      WBVar00934958
      WBVar00934959
      WBVar00934960
      WBVar00934961
      WBVar00934962
      WBVar00934963
      WBVar00934964
      WBVar00934965
      WBVar00246250
      WBVar00934966
      WBVar00934967
      WBVar00934968
      WBVar00934969
      WBVar00934970
      WBVar00934971
      WBVar00934972
      WBVar00934973
      WBVar01966866
      WBVar00934974
      WBVar02058561
      WBVar02058562
      WBVar00270714
      WBVar01495273
      WBVar01500245
      WBVar01581732
      WBVar01730518
      WBVar01730519
    Legacy_information: [C.elegansII] e1254 : defective formation of somatic gonad primordium; much germ line proliferation, almost no gamete maturation, variable vulval induction, no uterus. e1254/Df similar.ES3. ME0 (male somatic gonad also abnormal). OA4:e2547, e2551, q517, q518 (similar). [Hodgkin et al. 1989; CB; JK]
    Strain: WBStrain00022578
      WBStrain00022613
      WBStrain00004564
      WBStrain00050795
      WBStrain00054932
      WBStrain00054931
    RNASeq_FPKM (74)
    GO_annotation (30)
    Ortholog (56)
    Paralog: WBGene00000082 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000083 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00086562 Caenorhabditis elegans From_analysis: Panther
      WBGene00003242 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009958 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020567 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00021171 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003248 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: gon-1 encodes a functional metalloprotease that defines a new sub-family of secreted proteases known as MPT (metalloprotease with thrombospondin type 1 repeats); the other two members of this family are the bovine procollagen I N-protease ( PINP ) and the murine enzyme ADAMTS-1; gon-1 is essential for hermaphrodite gonadal morphogenesis and sequence homology with other metalloproteases suggests that it functions by remodeling the extracellular matrix; gon-1 is also required for protein transport from the endoplasmic reticulum (ER) to the Golgi, a function dependent on its C-terminal GON domain; GON-1 is expressed at high levels within the gonadal distal tip cell during migration and also in body wall muscle cells; in the distal tip cell, reporter fusion constructs expressing the GON domain localize to the endoplasmic reticulum, suggesting that GON-1 functions both intra- and extracellularly. Paper_evidence: WBPaper00003556
            WBPaper00003841
            WBPaper00040883
          Curator_confirmed: WBPerson1843
            WBPerson324
          Date_last_updated: 16 Mar 2012 00:00:00
      Automated_description: Enables metallopeptidase activity. Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; muscle organ morphogenesis; and negative regulation of presynapse assembly. Predicted to be located in extracellular matrix. Expressed in amphid neurons; excretory cell; gonad; motor neurons; and muscle cell. Used to study obesity and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Is an ortholog of human ADAMTS20 (ADAM metallopeptidase with thrombospondin type 1 motif 20) and ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9352 Homo sapiens Paper_evidence: WBPaper00048391
          Curator_confirmed: WBPerson324
          Date_last_updated: 28 Oct 2015 00:00:00
      DOID:9970 Homo sapiens Paper_evidence: WBPaper00061889
          Curator_confirmed: WBPerson324
          Date_last_updated: 28 Jun 2022 00:00:00
    Potential_model: DOID:7148 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:220)
  Models_disease_in_annotation: WBDOannot00000381
    WBDOannot00001255
  Molecular_info: Corresponding_CDS: F25H8.3a
      F25H8.3b
    Corresponding_CDS_history: F25H8.3:wp191
    Corresponding_transcript: F25H8.3c
      F25H8.3a.1
      F25H8.3a.2
      F25H8.3b.1
    Other_sequence: JI164015.1
      Dviv_isotig32909
      MP00069
      CBC09661_1
      Dviv_isotig16135
      Oden_isotig19638
      Hbac_isotig07485
    Associated_feature (17)
  Experimental_info: RNAi_result (23)
    Expr_pattern (11)
    Drives_construct: WBCnstr00003119
      WBCnstr00010223
      WBCnstr00021147
      WBCnstr00021148
      WBCnstr00036796
    Construct_product: WBCnstr00016199
      WBCnstr00020015
      WBCnstr00036796
    Microarray_results (23)
    Expression_cluster (151)
    Interaction (36)
  Map_info: Map: IV Position: 4.4533 Error: 0.0006
    Well_ordered
    Positive: Positive_clone: F25H8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data (2)
  Reference (59)
  Method: Gene