| WBGene00006773 | SMap | S_parent | Sequence | W02D3 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-37 | Person_evidence | WBPerson261 |
| | | Sequence_name | W02D3.9 |
| | | Molecular_name | W02D3.9 |
| | | | W02D3.9.1 |
| | | | CE14434 |
| | | Other_name | let-76 |
| | | | ESG | Accession_evidence | EMBL | AF001271 |
| | | | | | | AF001272 |
| | | | CELE_W02D3.9 | Accession_evidence | NDB | BX284601 |
| | | Public_name | unc-37 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143071 |
| | Allele | WBVar00241702 | Inferred_automatically | From strain object: BC124 |
| | | WBVar00143071 | Inferred_automatically | From strain object: BW1046 |
| | | | | From strain object: BW983 |
| | | | | From strain object: CB262 |
| | | WBVar00146671 | Inferred_automatically | From strain object: KR1406 |
| | | WBVar00275138 | Inferred_automatically | From strain object: NC37 |
| | | | | From strain object: NC85 |
| | | | | From strain object: NC92 |
| | | | | From strain object: NC93 |
| | | WBVar00275141 | Inferred_automatically | From strain object: NC85 |
| | | WBVar00275139 | Inferred_automatically | From strain object: NC92 |
| | | WBVar00275140 | Inferred_automatically | From strain object: NC93 |
| | | WBVar00094798 | Inferred_automatically | From strain object: OH4605 |
| | | WBVar00094795 | Inferred_automatically | From strain object: OH7410 |
| | | WBVar00094938 | Inferred_automatically | From strain object: OH9305 |
| | | WBVar00296257 |
| | | WBVar00253025 |
| | | WBVar00537342 |
| | | WBVar01499786 |
| | | WBVar00000520 |
| | | WBVar01499054 |
| | | WBVar01431965 |
| | | WBVar00306147 |
| | | WBVar00310800 |
| | | WBVar02001711 |
| | | WBVar00645621 |
| | | WBVar00645622 |
| | | WBVar00645623 |
| | | WBVar00645624 |
| | | WBVar00094941 |
| | | WBVar00645625 |
| | | WBVar00645626 |
| | | WBVar00645627 |
| | | WBVar00645628 |
| | | WBVar00645629 |
| | | WBVar00645630 |
| | | WBVar00645631 |
| | | WBVar00645632 |
| | | WBVar00645633 |
| | | WBVar00645634 |
| | | WBVar00336832 |
| | | WBVar00336833 |
| | | WBVar00336834 |
| | | WBVar00336835 |
| | | WBVar00336836 |
| | | WBVar00336837 |
| | | WBVar00336838 |
| | | WBVar01498959 |
| | Legacy_information | e262 : weak coiler fairly active. ES2 ME1. NA1. |
| | | s80 : L1 lethal. NA1. |
| | | L1 lethal |
| | | See also s80 |
| | | [C.elegansII] e262 : weak coiler, fairly active; phenotype similar to Unc-4. ES2 ME1. OA2 (recessive): s80 (pka let-76, L1 lethal), h763 (Unc, adult sterile). Also dominant suppressors of unc-4(e2322ts):wd14, wd16, wd17, wd18 (no phenotype alone, allele-specific dominant suppressors of e2322). Intragenic revertants, e.g. wd17wd19, resembl eh763. Cloned: encodes predicted 614 aa protein with similarity to groucho-related transcription factors, 6 WD40 repeats in C-term. [Miller et al. 1993; NC] |
| | Strain (15) |
| | RNASeq_FPKM (74) |
| | GO_annotation (35) |
| | Contained_in_operon | CEOP1348 |
| | Ortholog (54) |
| | Structured_description | Concise_description | unc-37 encodes a transducin-like WD-repeat protein orthologous to Drosophila Groucho; unc-37 plays an essential role in embryonic and neuronal fate specification; unc-37 genetically interacts with components of the transcriptional Mediator complex. | Paper_evidence | WBPaper00002798 |
| | | | | | WBPaper00005042 |
| | | | | | WBPaper00005136 |
| | | | | | WBPaper00030973 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 07 May 2010 00:00:00 |
| | | Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in chemical synaptic transmission; regulation of axonogenesis; and regulation of synapse structure or activity. Located in nucleus. Expressed in several structures, including germ line; head; and tail. Is an ortholog of human TLE2 (TLE family member 2, transcriptional corepressor). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | EFO:MONDO:0014769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30788) |
| Molecular_info | Corresponding_CDS | W02D3.9 |
| | Corresponding_transcript | W02D3.9.1 |
| | Other_sequence (80) |
| | Associated_feature | WBsf034259 |
| | | WBsf649254 |
| | | WBsf664356 |
| | | WBsf664357 |
| | | WBsf664358 |
| | | WBsf983991 |
| | | WBsf1009987 |
| | | WBsf219629 |
| | | WBsf219630 |
| | Transcription_factor | WBTranscriptionFactor000434 |
| Experimental_info | RNAi_result (34) |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00002546 |
| | | WBCnstr00004371 |
| | | WBCnstr00006094 |
| | | WBCnstr00006107 |
| | | WBCnstr00006110 |
| | | WBCnstr00010892 |
| | Construct_product | WBCnstr00006110 |
| | | WBCnstr00010892 |
| | Antibody | WBAntibody00000145 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00029359_1124 |
| | | WBPaper00029359_1141 |
| | | WBPaper00029359_1280 |
| | | WBPaper00029359_1304 |
| | | WBPaper00029359_1351 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1497 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1525 |
| | | WBPaper00029359_1604 |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_upregulated_protein |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048762:FOG-3_associated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053599:mitosis_vs_meiosis_upregulated |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056165:MINA-1_interacting_mRNA |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00057006:DietaryRestriction_downregulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00058691:WDR-5.1_interacting_protein |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:hmc_and_homolog |
| | | WBPaper00061340:hmc_homolog |
| | | WBPaper00061340:Parents_of_Y_DA6_DA7_DA9 |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:cids-2_2203-attf-2_2451 |
| | | WBPaper00061527:nrde-3-tra-4_10484 |
| | | WBPaper00061527:utx-1_2886-swan-1_2192 |
| | | WBPaper00062143:PQN-59_interacting |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062456:doxycycline_downregulated_CB4856_protein |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064494:postdauer_upregulated_AWA |
| | | WBPaper00064505:tamoxifen_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065132:asna-1(ok938)_downregulated_protein |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_6_3 |
| | | cgc4489_group_2 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025032:cluster_9 |
| | | WBPaper00025032:cluster_68 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Enterococcus_faecalis_downregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00032062:age_regulated_genes |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_3 |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:cluster_4 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(122_min) |
| | | [cgc5767]:expression_class_E_pi(41_min) |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (324) |
| Map_info | Map | I | Position | 1.30432 | Error | 0.000643 |
| | Well_ordered |
| | Positive | Inside_rearr | qDf16 |
| | | | nDp1 |
| | | Positive_clone | W02D3 | Person_evidence | WBPerson422 |
| | | | | | WBPerson43 |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 15 |
| | | | 7055 |
| | | Multi_point (24) |
| | | Pos_neg_data (41) |
| Reference (129) |
| Remark | [Miller D and Barnes T] unc-37 encodes a homolog of Drosophila groucho and therefore is likely to function as a transcription cofactor protein. |
| Method | Gene |
