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WormBase Tree Display for Gene: WBGene00009163

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Name Class

WBGene00009163SMapS_parentSequenceF26E4
IdentityVersion2
NameCGC_namedrsh-1Person_evidenceWBPerson490
Sequence_nameF26E4.10
Molecular_nameF26E4.10a
F26E4.10a.1
CE29039
F26E4.10b
CE46611
F26E4.10b.1
Other_nameCELE_F26E4.10Accession_evidenceNDBBX284601
Public_namedrsh-1
DB_infoDatabaseWormQTLgeneWBGene00009163
WormFluxgeneWBGene00009163
NDBlocus_tagCELE_F26E4.10
PanthergeneCAEEL|WormBase=WBGene00009163|UniProtKB=O01326
familyPTHR11207
NCBIgene172830
RefSeqproteinNM_001128988.5
NM_060198.5
KEGGKEGG_id3.1.26.3
NemaPathKEGG_id3.1.26.3
SwissProtUniProtAccO01326
TREEFAMTREEFAM_IDTF314734
UniProt_GCRPUniProtAccO01326
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:49WBPerson1971EventImportedInitial conversion from CDS class of WS125
223 Jul 2004 12:37:47WBPerson1971Name_changeCGC_namedrsh-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classdrsh
AlleleWBVar02157026
WBVar01432620
WBVar01499739
WBVar00662842
WBVar00662843
WBVar00662844
WBVar00662845
WBVar00662846
WBVar00662847
WBVar00662848
WBVar00662849
WBVar00662850
WBVar00662851
WBVar00091666
WBVar00662852
WBVar00662853
WBVar00662854
WBVar00662855
WBVar00662856
WBVar00662857
WBVar00662858
WBVar00662859
WBVar00662860
WBVar00662861
WBVar00662862
WBVar00662863
WBVar01342868
WBVar00662864
WBVar01342879
WBVar00662865
WBVar00662866
WBVar00662867
WBVar00662868
WBVar01342890
WBVar01499786
WBVar01342901
WBVar01499054
WBVar01713014
WBVar02128252
WBVar02128253
WBVar01910204
WBVar00276422
WBVar01283674
WBVar01422522
WBVar01556410
WBVar00342700
WBVar00342701
WBVar00342702
WBVar00342703
WBVar00342704
WBVar00342705
WBVar00342706
WBVar00156121
WBVar00342707
WBVar00156122
WBVar00342708
WBVar00156123
WBVar00156124
WBVar00342709
WBVar01500046
WBVar01498582
WBVar00249686
WBVar01475956
WBVar01498959
StrainWBStrain00036356
WBStrain00049716
WBStrain00049591
WBStrain00050761
WBStrain00050760
WBStrain00050750
WBStrain00054650
In_clusterconserved_miRNA_siRNA_cluster
RNASeq_FPKM (74)
GO_annotation (25)
Contained_in_operonCEOP1564
Ortholog (44)
Structured_descriptionConcise_descriptiondrsh-1 encodes a predicted RNase III-type ribonuclease that is orthologous to Drosophila and human Drosha; by homology, DRSH-1 is predicted to function as an endoribonuclease that, in the nucleus, initiates cleavage of primary miRNA transcripts (pri-mRNAs) into pre-miRNAs that are then exported to the cytoplasm for further processing; loss of drsh-1 activity via RNAi results in re-expression of a let-7-silenced reporter in adults, suggesting that DRSH-1 is required for let-7 processing; in addition, DRSH-1 also appears to be required for fertility, as adults lacking drsh-1 activity are sterile; along with PASH-1, a double-stranded RNA binding protein, DRSH-1 may be part of a conserved multiprotein complex that regulates nuclear pri-miRNA splicing.Paper_evidenceWBPaper00024573
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated09 Nov 2004 00:00:00
Automated_descriptionEnables ribonuclease III activity. Involved in primary miRNA processing and sexual reproduction. Predicted to be located in nucleus. Predicted to be part of microprocessor complex. Is an ortholog of human DROSHA (drosha ribonuclease III).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSF26E4.10a
F26E4.10b
Corresponding_CDS_historyF26E4.10:wp52
F26E4.10:wp62
F26E4.10b:wp228
Corresponding_transcriptF26E4.10a.1
F26E4.10b.1
Other_sequence (24)
Associated_featureWBsf649519
WBsf220147
WBsf220148
Experimental_infoRNAi_resultWBRNAi00045638Inferred_automaticallyRNAi_primary
WBRNAi00003483Inferred_automaticallyRNAi_primary
WBRNAi00061626Inferred_automaticallyRNAi_primary
WBRNAi00116443Inferred_automaticallyRNAi_primary
WBRNAi00084844Inferred_automaticallyRNAi_primary
WBRNAi00045637Inferred_automaticallyRNAi_primary
WBRNAi00003481Inferred_automaticallyRNAi_primary
WBRNAi00085189Inferred_automaticallyRNAi_primary
WBRNAi00031445Inferred_automaticallyRNAi_primary
Expr_patternExpr1026303
Expr1033995
Expr1149550
Expr2011097
Expr2029333
Drives_constructWBCnstr00032409
Construct_productWBCnstr00032409
Regulate_expr_clusterWBPaper00055896:drsh-1(ok369)_downregulated
WBPaper00055896:drsh-1(ok369)_upregulated
Microarray_results (25)
Expression_cluster (142)
Interaction (80)
WBProcessWBbiopr:00000057
WBbiopr:00000081
Map_infoMapIPosition3.89894Error0.002899
PositivePositive_cloneF26E4Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4838
4802
4721
Pseudo_map_position
Reference (22)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene