WormBase Tree Display for Gene: WBGene00001165

WBGene00001165 SMap: S_parent: Sequence: F56A11
  Identity: Version: 1
    Name: CGC_name: efn-4 Person_evidence: WBPerson893
      Sequence_name: F56A11.3
      Molecular_name: F56A11.3
        F56A11.3.1
        CE29503
      Other_name: mab-26
        CELE_F56A11.3 Accession_evidence: NDB BX284604
      Public_name: efn-4
    DB_info: Database: AceView gene 4B319
        WormQTL gene WBGene00001165
        SignaLink protein WBGene00001165
        WormFlux gene WBGene00001165
        NDB locus_tag CELE_F56A11.3
        Panther gene CAEEL|WormBase=WBGene00001165|UniProtKB=O44516
          family PTHR11304
        NCBI gene 176882
        RefSeq protein NM_067546.6
        SwissProt UniProtAcc O44516
        UniProt_GCRP UniProtAcc O44516
        OMIM gene 300035
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: efn
    Allele: WBVar00415596
      WBVar00415597
      WBVar00415598
      WBVar00415599
      WBVar00415600
      WBVar00415601
      WBVar00415602
      WBVar00415603
      WBVar00881237
      WBVar00415604
      WBVar00415605
      WBVar00881238
      WBVar01607785
      WBVar00415606
      WBVar00881239
      WBVar01607786
      WBVar00415607
      WBVar00881240
      WBVar01828033
      WBVar01607787
      WBVar00415608
      WBVar00881241
      WBVar00415609
      WBVar01607788
      WBVar00881242
      WBVar00415610
      WBVar00881243
      WBVar01607789
      WBVar00881244
      WBVar01607790
      WBVar01984386
      WBVar00415611
      WBVar01607791
      WBVar00881245
      WBVar01984387
      WBVar00415612
      WBVar00415613
      WBVar01984388
      WBVar01607792
      WBVar00881246
      WBVar01499166
      WBVar01984389
      WBVar00881247
      WBVar01607793
      WBVar00881248
      WBVar01984390
      WBVar01607794
      WBVar01984391
      WBVar01607795
      WBVar00881249
      WBVar00881250
      WBVar01984392
      WBVar01607796
      WBVar01607797
      WBVar01984393
      WBVar00881251
      WBVar01607798
      WBVar01984394
      WBVar00881252
      WBVar01984395
      WBVar01607799
      WBVar00881253
      WBVar01984396
      WBVar01607800
      WBVar00881254
      WBVar00881255
      WBVar01607801
      WBVar01607802
      WBVar00881256
      WBVar00881257
      WBVar01607803
      WBVar00881258
      WBVar01607804
      WBVar00881259
      WBVar01607805
      WBVar01607806
      WBVar00881260
      WBVar00881261
      WBVar01607807
      WBVar00881262
      WBVar01607808
      WBVar00881263
      WBVar00881264
      WBVar00881265
      WBVar00881266
      WBVar00881267
      WBVar00881268
      WBVar00881269
      WBVar00881270
      WBVar00881271
      WBVar00881272
      WBVar00881273
      WBVar00881274
      WBVar00881275
      WBVar01996167
      WBVar00881276
      WBVar00881277
      WBVar00881278
      WBVar00881279
      WBVar00881280
      WBVar01499384
      WBVar00881281
      WBVar00142926
      WBVar00881282
      WBVar01499385
      WBVar02003438
      WBVar00881283
      WBVar00088174
      WBVar00881284
      WBVar00881285
      WBVar02133204
      WBVar00881286
      WBVar02133205
      WBVar00881287
      WBVar00881288
      WBVar00881289
      WBVar00881290
      WBVar00881291
      WBVar00881292
      WBVar00881293
      WBVar00881294
      WBVar00881295
      WBVar00881296
      WBVar00881297
      WBVar00881298
      WBVar00881299
      WBVar00881300
      WBVar00881301
      WBVar01667620
      WBVar02050865
      WBVar01450162
      WBVar01450163
      WBVar01964240
      WBVar01964241
      WBVar01499633
      WBVar00000590
      WBVar01944849
      WBVar02048115
      WBVar01825548
      WBVar01481073
      WBVar02057428
      WBVar01481074
      WBVar01481075
      WBVar02092588
      WBVar02092589
      WBVar01647022
      WBVar01490481
      WBVar01499498
      WBVar01499499
      WBVar02125663
      WBVar00415580
      WBVar00415581
      WBVar00415582
      WBVar00415583
      WBVar00415584
      WBVar00415585
      WBVar01491592
      WBVar00415586
      WBVar00415587
      WBVar00143380
      WBVar00415588
      WBVar00415589
      WBVar00415590
      WBVar00415591
      WBVar01499328
      WBVar00415592
      WBVar01499329
      WBVar00415593
      WBVar00415594
      WBVar00415595
    Legacy_information: [C.elegansII] bx80sd : fusions among all rays; also head, body and (especially) tail deformities; bx80/+ impenetrant R4 to R3 transformation. [Chow and Emmons 1994; EM]
    Strain: WBStrain00005372
      WBStrain00007176
      WBStrain00049265
      WBStrain00049276
    RNASeq_FPKM (74)
    GO_annotation (33)
    Ortholog (50)
    Paralog: WBGene00001163 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001164 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006869 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: efn-4 encodes a divergent member of the ephrin family of ligands; efn-4 is required for neuroblast migrations during closure of the ventral gastrulation cleft and subsequent epidermal morphogenesis, possibly functioning independently of EFN-1, EFN-2, EFN-3, and the VAB-1 receptor during morphogenesis; EFN-4 can interact weakly with VAB-1 in vitro; EFN-4 is expressed in neural and epidermal precursors at the 100-cell stage, in head neurons, pharyngeal cells, lateral and tail neurons, and in the ectoderm during epidermal enclosure. Paper_evidence: WBPaper00003865
            WBPaper00005631
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 23 Jul 2008 00:00:00
      Automated_description: Predicted to enable ephrin receptor binding activity. Involved in several processes, including embryonic morphogenesis; nematode male tail tip morphogenesis; and regulation of axon guidance. Located in axon and neuronal cell body. Expressed in several structures, including CAN; epithelial cell; ganglia; intestinal cell; and somatic nervous system. Human ortholog(s) of this gene implicated in craniofrontonasal syndrome; dysostosis; and stomach cancer. Is an ortholog of human EFNB1 (ephrin B1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:1934 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3226)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3226)
      DOID:14737 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3226)
  Molecular_info: Corresponding_CDS: F56A11.3
    Corresponding_transcript: F56A11.3.1
    Other_sequence: CR11929
      TS00903
      TSC03402_1
      CRC05251_1
      CBC06448_1
      CR02130
    Associated_feature (22)
  Experimental_info: RNAi_result: WBRNAi00111800 Inferred_automatically: RNAi_primary
      WBRNAi00067312 Inferred_automatically: RNAi_primary
      WBRNAi00086136 Inferred_automatically: RNAi_primary
      WBRNAi00067361 Inferred_automatically: RNAi_primary
      WBRNAi00064650 Inferred_automatically: RNAi_primary
      WBRNAi00048574 Inferred_automatically: RNAi_primary
      WBRNAi00015760 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00000722
      WBCnstr00000723
      WBCnstr00006419
      WBCnstr00011024
      WBCnstr00037053
      WBCnstr00042431
      WBCnstr00042437
    Construct_product: WBCnstr00006419
      WBCnstr00021468
      WBCnstr00021469
      WBCnstr00021470
      WBCnstr00021472
      WBCnstr00021473
      WBCnstr00021477
      WBCnstr00022268
      WBCnstr00037053
    Antibody: WBAntibody00000596
    Microarray_results (21)
    Expression_cluster (158)
    Interaction (63)
    WBProcess: WBbiopr:00000025
  Map_info: Map: IV Position: -25.7615 Error: 0.138637
    Positive: Positive_clone: F56A11 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3132
        4992
        5641
  Reference (44)
  Method: Gene