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WormBase Tree Display for Gene: WBGene00002979

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Name Class

WBGene00002979SMapS_parentSequenceC46H11
IdentityVersion1
NameCGC_namelfe-2Person_evidenceWBPerson625
Sequence_nameC46H11.4
Molecular_name (16)
Other_nameC46H11.gCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CELE_C46H11.4Accession_evidenceNDBBX284601
Public_namelfe-2
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlfe
AlleleWBVar00635714
WBVar00536943
WBVar00635715
WBVar01282656
WBVar00635716
WBVar01282657
WBVar01282658
WBVar00635717
WBVar01282659
WBVar00635718
WBVar00635719
WBVar00635720
WBVar00635721
WBVar00635722
WBVar00635723
WBVar00635724
WBVar00635725
WBVar00635726
WBVar00635727
WBVar00635728
WBVar00635729
WBVar00635730
WBVar00635731
WBVar01318916
WBVar00635732
WBVar00635733
WBVar00635734
WBVar00635735
WBVar00635736
WBVar00635737
WBVar00248970
WBVar00635738
WBVar00635739
WBVar00635740
WBVar00635741
WBVar00635742
WBVar00635743
WBVar00635744
WBVar00635745
WBVar01602958
WBVar00635746
WBVar01411585
WBVar01902380
WBVar02127292
WBVar02127293
WBVar01475482
WBVar01475483
WBVar02127294
WBVar02127295
WBVar01475484
WBVar01475485
WBVar02127296
WBVar02073671
WBVar02073672
WBVar01499786
WBVar02073673
WBVar02073674
WBVar02073675
WBVar01495003
WBVar02073676
WBVar00333622
WBVar00333623
WBVar00333624
WBVar00333625
WBVar00333626
WBVar01431532
WBVar00333627
WBVar00333628
WBVar01431533
WBVar01431534
WBVar00333629
WBVar00333630
WBVar00333631
WBVar00333632
WBVar01911679
WBVar00333633
WBVar01911680
WBVar00333634
WBVar01911681
WBVar00333635
WBVar01911682
WBVar00333636
WBVar01943154
WBVar00333637
WBVar00333638
WBVar00333639
WBVar01993206
WBVar00316070
WBVar01993207
WBVar00333640
WBVar00333641
WBVar00333642
WBVar00333643
WBVar00333644
WBVar00262538
WBVar02145347
WBVar00099192
WBVar00635671
WBVar00635672
WBVar00635673
WBVar00635674
WBVar00635675
WBVar00276083
WBVar00276084
WBVar00635676
WBVar00635677
WBVar00635678
WBVar00635679
WBVar00240645
WBVar00153459
WBVar00153460
WBVar00635680
WBVar00153461
WBVar00635681
WBVar00635682
WBVar00153462
WBVar00635683
WBVar00635684
WBVar00635685
WBVar00635686
WBVar00635687
WBVar00635688
WBVar00635689
WBVar00635690
WBVar00635691
WBVar00635692
WBVar00635693
WBVar00635694
WBVar00635695
WBVar00635696
WBVar00635697
WBVar00635698
WBVar00635699
WBVar00635700
WBVar00635701
WBVar00635702
WBVar00635703
WBVar00635704
WBVar00635705
WBVar00635706
WBVar00635707
WBVar00635708
WBVar01498959
WBVar00635709
WBVar00635710
WBVar00635711
WBVar00635712
WBVar00635713
Legacy_information[Clandinin T] mutations suppress let-23 sterility
[C.elegansII] sy326 : suppresses sterility of let-23 mutations. [PS]
StrainWBStrain00030843
WBStrain00030855
RNASeq_FPKM (74)
GO_annotation (14)
Ortholog (44)
ParalogWBGene00014081Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00021260Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00020631Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00009262Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionlfe-2 encodes an inositol (1,4,5) triphosphate-3-kinase (IP3K); lfe-2 activity is required for normal levels of hermaphrodite fertility and for tissue-specific negative regulation of the LET-23 signaling pathway that controls spermathecal dilation and ovulation; in vitro, LFE-2 can exhibit catalytic activity, converting IP3 to IP4; an lfe-2::GFP transcriptional fusion is expressed in the adult spermatheca and in the pharynx and gut throughout larval and adult stages; misexpression of LFE-2 in gravid adults via heat shock results in ovulation defects, consistent with a role for LFE-2 in regulating this process.Paper_evidenceWBPaper00003017
Curator_confirmedWBPerson1843
Date_last_updated13 Jan 2006 00:00:00
Automated_descriptionPredicted to enable inositol tetrakisphosphate kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Predicted to be involved in inositol phosphate biosynthetic process. Predicted to be located in cytoplasm and nucleus. Expressed in spermatheca. Human ortholog(s) of this gene implicated in colorectal cancer. Is an ortholog of human ITPKA (inositol-trisphosphate 3-kinase A); ITPKB (inositol-trisphosphate 3-kinase B); and ITPKC (inositol-trisphosphate 3-kinase C).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:9256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:14897)
Molecular_infoCorresponding_CDSC46H11.4a
C46H11.4b
C46H11.4c
C46H11.4e
C46H11.4f
Corresponding_CDS_historyC46H11.4d:wp273
C46H11.4f:wp261
Corresponding_transcriptC46H11.4a.1
C46H11.4b.1
C46H11.4c.1
C46H11.4e.1
C46H11.4f.1
C46H11.4f.2
Other_sequence (115)
Associated_featureWBsf643259
WBsf656279
WBsf656280
WBsf656281
WBsf656282
WBsf983577
WBsf983578
WBsf983579
WBsf983580
WBsf1009756
WBsf217614
Experimental_infoRNAi_resultWBRNAi00003167Inferred_automaticallyRNAi_primary
WBRNAi00062776Inferred_automaticallyRNAi_primary
WBRNAi00027799Inferred_automaticallyRNAi_primary
WBRNAi00042628Inferred_automaticallyRNAi_primary
WBRNAi00062771Inferred_automaticallyRNAi_primary
WBRNAi00007487Inferred_automaticallyRNAi_primary
WBRNAi00003168Inferred_automaticallyRNAi_primary
WBRNAi00066573Inferred_automaticallyRNAi_primary
WBRNAi00003166Inferred_automaticallyRNAi_primary
WBRNAi00042627Inferred_automaticallyRNAi_primary
Expr_patternExpr505
Expr1017641
Expr1031379
Expr1146612
Expr2013089
Expr2031321
Drives_constructWBCnstr00012404
WBCnstr00036310
Construct_productWBCnstr00036310
Microarray_results (47)
Expression_cluster (149)
Interaction (55)
WBProcessWBbiopr:00000067
Map_infoMapIPosition-0.423671Error0.000969
PositivePositive_cloneC46H11Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4461
4474
Pseudo_map_position
Reference (27)
RemarkMap I
lfe-2 was previously attached to C46H11.5 which has since become a splice variant of C46H11.4
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene