WormBase Tree Display for Variation: WBVar00275548

WBVar00275548 Evidence: Paper_evidence: WBPaper00005198
      WBPaper00026975
  Name: Public_name: zu405
    Other_name: C09G9.6.1:c.719C>T
      CE03005:p.Pro240Leu
    HGVSg: CHROMOSOME_IV:g.8889984C>T
  Sequence_details: SMap: S_parent: Sequence: C27B7
    Flanking_sequences: ctttagaaatgtttgccaggccatcaactc agatgagccagcggctaaattgccactagg
    Mapping_target: C27B7
    Type_of_mutation: Substitution: c t Paper_evidence: WBPaper00026975
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00035066
      WBStrain00035067
      WBStrain00035068
      WBStrain00048324
      WBStrain00052677
    Laboratory: JJ
    Status: Live
  Affects: Gene: WBGene00003864
    Transcript: C09G9.6.1 (12)
    Interactor: WBInteraction000051359
      WBInteraction000501903
      WBInteraction000501904
      WBInteraction000501905
      WBInteraction000501906
      WBInteraction000501907
      WBInteraction000501908
      WBInteraction000501909
      WBInteraction000501910
      WBInteraction000524794
  Genetics: Interpolated_map_position: IV 3.99916
    Mapping_data: In_2_point: 7138
  Description: Phenotype (13)
    Phenotype_not_observed: WBPhenotype:0000306 Paper_evidence: WBPaper00036019
        Curator_confirmed: WBPerson712
        Remark: No ectopic expression of fkh-6::GFP was observed. Paper_evidence: WBPaper00036019
            Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00036019
            Curator_confirmed: WBPerson712
      WBPhenotype:0000436 Paper_evidence: WBPaper00005930
        Curator_confirmed: WBPerson2021
        Remark: Spatial localization of OMA-1 resembles wild-type. OMA-1 protein colocalizes with P-granules in the germline precursors in zu405 mutant embryos Paper_evidence: WBPaper00005930
            Curator_confirmed: WBPerson2021
        Semi_dominant: Paper_evidence: WBPaper00005930
          Curator_confirmed: WBPerson2021
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00005930
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00005930
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00005930
              Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00005930
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Costaining with various antibodies known to recognize P-granules, such as OIC4, MEX-1 antibody, and POS-1 antibody Paper_evidence: WBPaper00005930
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001021 Paper_evidence: WBPaper00036019
        Curator_confirmed: WBPerson712
        Remark: Mutant males are not feminized based on fkh-6::GFP expression. Paper_evidence: WBPaper00036019
            Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00036019
            Curator_confirmed: WBPerson712
      WBPhenotype:0001357 Paper_evidence: WBPaper00036019
        Curator_confirmed: WBPerson712
        Remark: No defects in male gonad morphology was observed. Paper_evidence: WBPaper00036019
            Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00036019
            Curator_confirmed: WBPerson712
  Reference (11)
  Method: Substitution_allele