WormBase Tree Display for Variation: WBVar00249516

WBVar00249516 Name: Public_name: tm472
    Other_name: B0285.5.3:c.666_1249del
      CE36681:p.Asn223GlyfsTer38
      B0285.5.2:c.666_1249del
      B0285.5.1:c.666_1249del
    HGVSg: CHROMOSOME_III:g.4346657_4347904del
  Sequence_details: SMap: S_parent: Sequence: B0285
    Flanking_sequences: aatgcatgaaacaactgaacgattgttttt tggaaagatcaattgccgagagaaagttgg
    Mapping_target: B0285
    Source_location: 7 CHROMOSOME_III 4346656 4347905 Inferred_automatically: National_Bioresource_Project
    Type_of_mutation: Deletion
    PCR_product: tm472_external
      tm472_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00029322
      WBStrain00040542
    Laboratory: FX
    Author: Mitani S
    DB_info: Database: National_Bioresource_Project seq 472
    NBP_allele
    Status: Live
  Affects: Gene: WBGene00002003
    Transcript: B0285.5.1 (11)
      B0285.5.3 (11)
      B0285.5.2 (11)
    Interactor: WBInteraction000524033
      WBInteraction000524034
  Isolation: Mutagen: TMP/UV
  Genetics: Map: III
  Description: Phenotype: WBPhenotype:0000229 Paper_evidence: WBPaper00029002
        Curator_confirmed: WBPerson557
      WBPhenotype:0000541 Paper_evidence: WBPaper00006471
        Curator_confirmed: WBPerson2021
        Remark: Roughly half of the commissures that make an incorrect midline choice reach the dorsal nerve cord Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0005303 PATO:0000460 Paper_evidence: WBPaper00006471
                Curator_confirmed: WBPerson2021
            WBbt:0005270 PATO:0000460 Paper_evidence: WBPaper00006471
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: oxIs12 Paper_evidence: WBPaper00006471
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000632 Paper_evidence: WBPaper00006471
        Curator_confirmed: WBPerson2021
        Remark: Severe defasciculation defects Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0005303 PATO:0000460 Paper_evidence: WBPaper00006471
                Curator_confirmed: WBPerson2021
            WBbt:0005270 PATO:0000460 Paper_evidence: WBPaper00006471
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: oxIs12 Paper_evidence: WBPaper00006471
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001761 Paper_evidence: WBPaper00006471
        Curator_confirmed: WBPerson2021
        Remark: Midline crossover defects of PVQL and PVQR as well as AVK axons, with either contralateral analog inappropriately crossing the midline Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006976 PATO:0000460 Paper_evidence: WBPaper00006471
                Curator_confirmed: WBPerson2021
            WBbt:0006823 PATO:0000460 Paper_evidence: WBPaper00006471
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: oyIs14, bwIs2 Paper_evidence: WBPaper00006471
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001767 Paper_evidence: WBPaper00006471
        Curator_confirmed: WBPerson2021
        Remark: The midline choice (where the axons turn at the midline either to the left or right) is affected. Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0005303 PATO:0000460 Paper_evidence: WBPaper00006471
                Curator_confirmed: WBPerson2021
            WBbt:0005270 PATO:0000460 Paper_evidence: WBPaper00006471
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: oxIs12 Paper_evidence: WBPaper00006471
              Curator_confirmed: WBPerson2021
      WBPhenotype:0002491 Paper_evidence: WBPaper00006471
        Curator_confirmed: WBPerson2021
        Remark: Ectopic neurite outgrowth defects in the DVB tail motor neurons Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0004822 PATO:0000460 Paper_evidence: WBPaper00006471
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: oxIs12 Paper_evidence: WBPaper00006471
              Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000012 Paper_evidence: WBPaper00006471
        Curator_confirmed: WBPerson2021
        Remark: Not daf-c Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000054 Paper_evidence: WBPaper00040941
        Curator_confirmed: WBPerson1705
      WBPhenotype:0000062 Paper_evidence: WBPaper00006471
        Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson48
          WBPerson2021
        Remark: Classified as homozygous viable by the National Bioresource Project of Japan. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson48
            Laboratory_evidence: FX
          Non-lethal Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000245 Paper_evidence: WBPaper00006471
        Curator_confirmed: WBPerson2021
        Remark: No defects in SM migration Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000470 Paper_evidence: WBPaper00006471
        Curator_confirmed: WBPerson2021
        Remark: No defects in HSN migration Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: mgIs71 Paper_evidence: WBPaper00006471
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000604 Paper_evidence: WBPaper00006471
        Curator_confirmed: WBPerson2021
        Remark: The nervous system is grossly intact in all mutants Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term (13)
        Phenotype_assay: Treatment: DiI staining Paper_evidence: WBPaper00006471
              Curator_confirmed: WBPerson2021
          Genotype: oyIs17, otEx404, mgIs18, uIs25, otEx1043, zdIs5, otEx1082, otIs39, evIs82b, wdIs3 Paper_evidence: WBPaper00006471
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000643 Paper_evidence: WBPaper00006471
        Curator_confirmed: WBPerson2021
        Remark: Non-Unc Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000688 Paper_evidence: WBPaper00006471
        Curator_confirmed: WBPerson2021
        Remark: Non-sterile Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00006471
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001767 Paper_evidence: WBPaper00032413
        Curator_confirmed: WBPerson2021
        Remark: Removal of C5-epimerization does not result in significant defects in the sidedness of DA/DB motor axon projections Paper_evidence: WBPaper00032413
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00032413
            Curator_confirmed: WBPerson2021
  Reference: WBPaper00040941
    WBPaper00032413
    WBPaper00029002
    WBPaper00006471
  Remark: 15975/15976-17223/17224 (1248 bp deletion)
    This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use. Paper_evidence: WBPaper00041807
  Method: NBP_knockout_allele