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WormBase Tree Display for Variation: WBVar00242723

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WBVar00242723	Name	Public_name	se2
	Sequence_details	SeqStatus	Pending_curation
	Variation_type	Allele
	Origin	Species	Caenorhabditis elegans
		Laboratory	SW
		Status	Live
	Affects	Gene	WBGene00003394
	Description	Phenotype	WBPhenotype:0000184	Paper_evidence	WBPaper00002871
				Curator_confirmed	WBPerson2987
				Remark	In wild-type embryos, an MS descendant called MSpaapp is born in an unequal cleavage and soon afterward undergoes programmed cell death. In lineaged mom-1(se2) mutant embryos, authors found that MSpaapp was born in a cleavage that was either equal or reversed and did not undergo programmed cell death.	Paper_evidence	WBPaper00002871
						Curator_confirmed	WBPerson2987
				EQ_annotations	Anatomy_term	WBbt:0006204	PATO:0000460	Paper_evidence	WBPaper00002871
								Curator_confirmed	WBPerson2987
						WBbt:0005878	PATO:0000460	Paper_evidence	WBPaper00002871
								Curator_confirmed	WBPerson2987
			WBPhenotype:0000426	Paper_evidence	WBPaper00002871
				Curator_confirmed	WBPerson2987
				Remark	8-cell stage mom-1(se2) mutant embryos were stained for POP-1 (with anti-POP-1 antibodies); about 65% (n = 30) of mom-1(se2) mutant embryos had higher than normal levels of POP-1 staining in the E nucleus (data not shown).	Paper_evidence	WBPaper00002871
						Curator_confirmed	WBPerson2987
				Penetrance	Incomplete	65% penetrance	Paper_evidence	WBPaper00002871
							Curator_confirmed	WBPerson2987
				EQ_annotations	Anatomy_term	WBbt:0004804	PATO:0000460	Paper_evidence	WBPaper00002871
								Curator_confirmed	WBPerson2987
						WBbt:0001975	PATO:0000460	Paper_evidence	WBPaper00002871
								Curator_confirmed	WBPerson2987
			WBPhenotype:0000472	Paper_evidence	WBPaper00002871
				Curator_confirmed	WBPerson2987
				Remark	Figure 3d, Table 1	Paper_evidence	WBPaper00002871
						Curator_confirmed	WBPerson2987
				Penetrance	Incomplete	62% penetrance	Paper_evidence	WBPaper00002871
							Curator_confirmed	WBPerson2987
			WBPhenotype:0000760	Paper_evidence	WBPaper00002871
				Curator_confirmed	WBPerson2987
				Remark	The ABar cells of mom-1(se2) embryos exhibit abnormal spindle orientation, with ABar spindle parallel (instead of orthogonal as in wild type) to the ABpr spindle (Figure 3).	Paper_evidence	WBPaper00002871
						Curator_confirmed	WBPerson2987
				EQ_annotations	Anatomy_term	WBbt:0006411	PATO:0000460	Paper_evidence	WBPaper00002871
								Curator_confirmed	WBPerson2987
			WBPhenotype:0000864	Paper_evidence	WBPaper00002871
				Curator_confirmed	WBPerson2987
				Remark	Terminal stage mom-1(se2) mutant embryos have not elongated (Figure 3).	Paper_evidence	WBPaper00002871
						Curator_confirmed	WBPerson2987
			WBPhenotype:0000867	Paper_evidence	WBPaper00002871
				Curator_confirmed	WBPerson2987
			WBPhenotype:0001235	Paper_evidence	WBPaper00002871
				Curator_confirmed	WBPerson2987
				Remark	In wild-type embryos, an MS descendant called MSpaapp is born in an unequal cleavage and soon afterward undergoes programmed cell death. In lineaged mom-1(se2) mutant embryos, authors found that MSpaapp was born in a cleavage that was either equal or reversed and did not undergo programmed cell death.	Paper_evidence	WBPaper00002871
						Curator_confirmed	WBPerson2987
				EQ_annotations	Anatomy_term	WBbt:0006204	PATO:0000460	Paper_evidence	WBPaper00002871
								Curator_confirmed	WBPerson2987
						WBbt:0005878	PATO:0000460	Paper_evidence	WBPaper00002871
								Curator_confirmed	WBPerson2987
			WBPhenotype:0001495	Paper_evidence	WBPaper00002871
				Curator_confirmed	WBPerson2987
				Remark	E daughter cells of mom-1(se2) mutant embryos divide earlier (compared to MS daughters) than in wild type embryos	Paper_evidence	WBPaper00002871
						Curator_confirmed	WBPerson2987
				EQ_annotations	Anatomy_term	WBbt:0006733	PATO:0000460	Paper_evidence	WBPaper00002871
								Curator_confirmed	WBPerson2987
						WBbt:0006612	PATO:0000460	Paper_evidence	WBPaper00002871
								Curator_confirmed	WBPerson2987
			WBPhenotype:0001635	Paper_evidence	WBPaper00002871
				Curator_confirmed	WBPerson2987
				Remark	E blastomeres produced pharyngeal cells (aberrantly) instead of endoderm in 10/16 (63%) of mom-1(se2) mutant embryos (Figure 3f)	Paper_evidence	WBPaper00002871
						Curator_confirmed	WBPerson2987
				Penetrance	Incomplete	63% penetrance	Paper_evidence	WBPaper00002871
							Curator_confirmed	WBPerson2987
				EQ_annotations	Anatomy_term	WBbt:0004804	PATO:0000460	Paper_evidence	WBPaper00002871
								Curator_confirmed	WBPerson2987
	Reference	WBPaper00002871
	Method	Allele