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WormBase Tree Display for Variation: WBVar00241036

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Name Class

WBVar00241036EvidencePaper_evidenceWBPaper00001677
NamePublic_nameq224
Other_nameCE00237:p.Gly1043Glu
F02A9.6.1:c.3128G>A
HGVSgCHROMOSOME_III:g.9098521G>A
Sequence_detailsSMapS_parentSequenceF02A9
Flanking_sequencesctgcattgatgctagtagcacgtgaactcgaaaacatcaagtggagatggcagagcttct
Mapping_targetF02A9
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00001677
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00022516
WBStrain00022530
WBStrain00022538
WBStrain00047329
LaboratoryJK
StatusLive
AffectsGeneWBGene00001609
TranscriptF02A9.6.1 (12)
InteractorWBInteraction000009194
WBInteraction000502006
WBInteraction000517590
WBInteraction000518397
IsolationMutagenEMS
GeneticsInterpolated_map_positionIII0.163976
DescriptionPhenotype (20)
Phenotype_not_observedWBPhenotype:0000412Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
RemarkAnimals responded robustly to octanol.Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00001966Paper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00038400
Curator_confirmedWBPerson712
WBPhenotype:0000739Paper_evidenceWBPaper00029334
Curator_confirmedWBPerson712
RemarkDifferent life stages of N2 or glp-1 nematodes exposed to 0, 100, or 200 J/m2 UVC exhibited marked differences in susceptibility to induction of DNA damage (Figure 2), with starved L1 larvae the most and 1-day-old N2 adults the least susceptible. No differences were observed in terms of damage to the nuclear (DNA polymerase epsilon target) and mitochondrial genome at any life stage. We also compared eggs isolated by bleach-sodium hydroxide treatment but not exposed to UVC, with unexposed eggs isolated by wash-off (eggs already laid), to test whether the bleach-sodium hydroxide treatment had a detectable effect on DNA integrity. No difference was detected (data not shown).Paper_evidenceWBPaper00029334
Curator_confirmedWBPerson712
Phenotype_assayStrainWBStrain00022538Paper_evidenceWBPaper00029334
Curator_confirmedWBPerson712
WBPhenotype:0000977Paper_evidenceWBPaper00001007
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00001007
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00001007
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00001007
Curator_confirmedWBPerson2021
WBPhenotype:0001661Paper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
RemarkAsymmetric expression in AWC was normalPaper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
WBPhenotype:0001938Paper_evidenceWBPaper00029334
Curator_confirmedWBPerson712
RemarkNo detectable difference in repair was observed between the N2 and glp-1 L1 larvae (Figure 4). Removal of nuclear lesions was apparent in glp-1 adults. In N2 the lesion frequency decreased significantly (Figure 3a) in both the nuclear and mitochondrial genomes at 6 and 24 hours.Paper_evidenceWBPaper00029334
Curator_confirmedWBPerson712
Phenotype_assay (2)
WBPhenotype:0002430Paper_evidenceWBPaper00029334
Curator_confirmedWBPerson712
RemarkDifferent life stages of N2 or glp-1 nematodes exposed to 0, 100, or 200 J/m2 UVC exhibited marked differences in susceptibility to induction of DNA damage (Figure 2), with starved L1 larvae the most and 1-day-old N2 adults the least susceptible. No differences were observed in terms of damage to the nuclear (DNA polymerase epsilon target) and mitochondrial genome at any life stage. We also compared eggs isolated by bleach-sodium hydroxide treatment but not exposed to UVC, with unexposed eggs isolated by wash-off (eggs already laid), to test whether the bleach-sodium hydroxide treatment had a detectable effect on DNA integrity. No difference was detected (data not shown).Paper_evidenceWBPaper00029334
Curator_confirmedWBPerson712
Phenotype_assayStrainWBStrain00022538Paper_evidenceWBPaper00029334
Curator_confirmedWBPerson712
Reference (16)
MethodSubstitution_allele