WormBase Tree Display for Variation: WBVar00145685

WBVar00145685 Name: Public_name: gk278
    HGVSg: CHROMOSOME_II:g.9323491_9324362del
  Sequence_details: SMap: S_parent: Sequence: D2013
    Flanking_sequences: aatttctcgaaaacacctgttttccaaaac agtttcccgaaagaatcgcaaaatggcagg
    Mapping_target: D2013
    Type_of_mutation: Deletion
    PCR_product: gk278_external
      gk278_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00035887
    Laboratory: VC
    Person: WBPerson427
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00006520
    Transcript: D2013.10.1 VEP_consequence: coding_sequence_variant,5_prime_UTR_variant
        VEP_impact: MODIFIER
        cDNA_position: ?-403
        CDS_position: ?-403
        Protein_position: ?-135
        Exon_number: 1/1
  Isolation: Mutagen: TMP/UV
  Genetics: Mapping_data: In_multi_point: 5536
  Description: Phenotype: WBPhenotype:0000015 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure 5: no chemotaxis to food/HB101 E. coli bacteria Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
      WBPhenotype:0000023 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure 3: increased paralysis with serotonin and citalopram (SSRI); decreased paralysis with ketanserin (serotonin antagonist) Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
        Affected_by: Molecule: WBMol:00004929 Paper_evidence: WBPaper00058949
              Curator_confirmed: WBPerson7631
            WBMol:00003496 Paper_evidence: WBPaper00058949
              Curator_confirmed: WBPerson7631
            WBMol:00003980 Paper_evidence: WBPaper00058949
              Curator_confirmed: WBPerson7631
      WBPhenotype:0000640 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure 2: increased rate of egg laying with preservation of fertility Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
      WBPhenotype:0000673 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure 2: increased brood size Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
      WBPhenotype:0001171 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure 2: decreased median lifespan Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
      WBPhenotype:0001437 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure 5: no loss of octanol chemotaxis sensitivity upon starvation (similar to mod-5 mutants) Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
        Affected_by: Molecule: WBMol:00007778 Paper_evidence: WBPaper00058949
              Curator_confirmed: WBPerson7631
      WBPhenotype:0004028 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure 4: defective enhanced slowing with normal basal slowing response Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
    Phenotype_not_observed: WBPhenotype:0000016 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure S6 Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
        Affected_by: Molecule: WBMol:00003650 Paper_evidence: WBPaper00058949
              Curator_confirmed: WBPerson7631
      WBPhenotype:0000231 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure S2 Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
      WBPhenotype:0000249 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure S9 Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
      WBPhenotype:0000303 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure S9 Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
        Affected_by: Molecule: WBMol:00002819 Paper_evidence: WBPaper00058949
              Curator_confirmed: WBPerson7631
      WBPhenotype:0000650 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure S2 Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
      WBPhenotype:0000747 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure S2 Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
      WBPhenotype:0000848 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure S2 Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
      WBPhenotype:0000878 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure S5 Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
      WBPhenotype:0001213 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure S2 Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
      WBPhenotype:0001331 Paper_evidence: WBPaper00058949
        Curator_confirmed: WBPerson7631
        Remark: Figure S5 Paper_evidence: WBPaper00058949
            Curator_confirmed: WBPerson7631
  Reference: WBPaper00058949
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele