WormBase Tree Display for Variation: WBVar00143865

WBVar00143865 Evidence: Paper_evidence: WBPaper00006502
  Name: Public_name: e1256
    Other_name: ZK381.1a.1:c.71C>T
      CE07625:p.Thr24Met
    HGVSg: CHROMOSOME_IV:g.6977596C>T
  Sequence_details: SMap: S_parent: Sequence: ZK381
    Flanking_sequences: aaattcctatagccagccagtggaaggcca gtttcccgttgatctagagattgaaaaaaa
    Mapping_target: ZK381
    Type_of_mutation: Substitution: c t
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00004278
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00001862
    Transcript: ZK381.1a.1 (12)
    Interactor: WBInteraction000558062
      WBInteraction000558063
      WBInteraction000558064
  Genetics: Interpolated_map_position: IV 3.26859
    Mapping_data: In_pos_neg_data: 5437
        5438
        5439
        5440
        5441
        5442
        5443
  Description: Phenotype: WBPhenotype:0000050 Paper_evidence: WBPaper00000179
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: 70.9% eggs never hatch, yet are refractile; wild type animals produce 0.8% inviable zygotes. Paper_evidence: WBPaper00000179
            Curator_confirmed: WBPerson712
          males sire inviable zygotes Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000056 PATO:0000460 Person_evidence: WBPerson261
                Curator_confirmed: WBPerson712
      WBPhenotype:0000154 Paper_evidence: WBPaper00000179
        Curator_confirmed: WBPerson712
        Remark: Animals have an average brood size of 4523 s.d. (9 broods counted), wild type has average brood size 33034 s.d. (8 broods counted). Paper_evidence: WBPaper00000179
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00000179
                Curator_confirmed: WBPerson712
      WBPhenotype:0000351 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: many unhatched eggs (71%) Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000742 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: some reduction in autosomal recombination Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000863 Paper_evidence: WBPaper00000179
        Curator_confirmed: WBPerson712
        Remark: Males exhibit 5.4% wild type fertility. Paper_evidence: WBPaper00000179
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000056 PATO:0000460 Paper_evidence: WBPaper00000179
                Curator_confirmed: WBPerson712
      WBPhenotype:0001175 Paper_evidence: WBPaper00000179
          WBPaper00048917
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
          WBPerson721
        Remark: Animals segregate 10.9% males compared to 0.3% segregated by wild type animals. Paper_evidence: WBPaper00000179
            Curator_confirmed: WBPerson712
          stronger allele than e1147; 11% Him Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001499 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: probably generalized meiotic nondisjunction, effects on segregation of free duplications Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001583 Paper_evidence: WBPaper00000179
        Curator_confirmed: WBPerson712
        Remark: Animals segregate a small percentage (1.2%) of short animals shown to be 3X hermaphrodites (wild type segregates 0.04% 3X herm.). Paper_evidence: WBPaper00000179
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00000179
                Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000517 Paper_evidence: WBPaper00000179
        Curator_confirmed: WBPerson712
        Remark: Animals are indistinguishable from wild type in terms of behavior. Paper_evidence: WBPaper00000179
            Curator_confirmed: WBPerson712
      WBPhenotype:0000520 Paper_evidence: WBPaper00000179
        Curator_confirmed: WBPerson712
        Remark: Both hermaphrodites and males are indistinguishable from wild type in terms of superficial anatomy. Paper_evidence: WBPaper00000179
            Curator_confirmed: WBPerson712
      WBPhenotype:0001631 Paper_evidence: WBPaper00000179
        Curator_confirmed: WBPerson712
        Remark: The sex ratio of cross progeny sired by him males does not significantly differ from 1:1. Paper_evidence: WBPaper00000179
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000056 PATO:0000460 Paper_evidence: WBPaper00000179
                Curator_confirmed: WBPerson712
  Reference: WBPaper00015329
    WBPaper00014382
    WBPaper00000179
    WBPaper00011748
    WBPaper00011726
    WBPaper00023340
    WBPaper00048917
  Method: Substitution_allele