WormBase Tree Display for Variation: WBVar00092058
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WBVar00092058 | Name | Public_name | ok778 | |||||
---|---|---|---|---|---|---|---|---|
Other_name | C50H2.1b.1:c.263+96_1931delinsGGTGAGCAGCAGGCACAGATAATGTTGAGATAACACCCCTTCAGATCATCACACATCCTTGTTTTTTTCCTTGTTTTCTCACACTCTTCGGTTTCCTTATTTTTTCTGTTCGAAGTGATGTGACATGTCATCTGTTTCCAATTTTTTCGCAAAAAATGTTCAGTCTTAAGAGAGGATCCTGGTTTGAGCTTATCCTCCTGTTCATTTTAAATCTATGCTCTGAGAACCCTCCTGAACAAACAATGCGTGTCTTTTGTGGGATATCAGATAAAAAGTTTAAAAACCCACTTTTCTATTGATCTTACCGCTTTATGTGTGTGCCGCCCAAAAAATGAAAATTTGTTAATTTTTATAGAAGGAACATGTGTTGATTTCGGAGACCGGAGATGGGTG | |||||||
C50H2.1a.1:c.263+96_1931delinsGGTGAGCAGCAGGCACAGATAATGTTGAGATAACACCCCTTCAGATCATCACACATCCTTGTTTTTTTCCTTGTTTTCTCACACTCTTCGGTTTCCTTATTTTTTCTGTTCGAAGTGATGTGACATGTCATCTGTTTCCAATTTTTTCGCAAAAAATGTTCAGTCTTAAGAGAGGATCCTGGTTTGAGCTTATCCTCCTGTTCATTTTAAATCTATGCTCTGAGAACCCTCCTGAACAAACAATGCGTGTCTTTTGTGGGATATCAGATAAAAAGTTTAAAAACCCACTTTTCTATTGATCTTACCGCTTTATGTGTGTGCCGCCCAAAAAATGAAAATTTGTTAATTTTTATAGAAGGAACATGTGTTGATTTCGGAGACCGGAGATGGGTG | ||||||||
HGVSg | CHROMOSOME_V:g.9890318_9893541delinsGGTGAGCAGCAGGCACAGATAATGTTGAGATAACACCCCTTCAGATCATCACACATCCTTGTTTTTTTCCTTGTTTTCTCACACTCTTCGGTTTCCTTATTTTTTCTGTTCGAAGTGATGTGACATGTCATCTGTTTCCAATTTTTTCGCAAAAAATGTTCAGTCTTAAGAGAGGATCCTGGTTTGAGCTTATCCTCCTGTTCATTTTAAATCTATGCTCTGAGAACCCTCCTGAACAAACAATGCGTGTCTTTTGTGGGATATCAGATAAAAAGTTTAAAAACCCACTTTTCTATTGATCTTACCGCTTTATGTGTGTGCCGCCCAAAAAATGAAAATTTGTTAATTTTTATAGAAGGAACATGTGTTGATTTCGGAGACCGGAGATGGGTG | |||||||
Sequence_details | SMap | S_parent | Sequence | C50H2 | ||||
Flanking_sequences | caaaaattggatttaatttccaattatagt | aactgatttgatttgctggtttccaaccct | ||||||
Mapping_target | C50H2 | |||||||
Type_of_mutation | Insertion | GGTGAGCAGCAGGCACAGATAATGTTGAGATAACACCCCTTCAGATCATCACACATCCTTGTTTTTTTCCTTGTTTTCTCACACTCTTCGGTTTCCTTATTTTTTCTGTTCGAAGTGATGTGACATGTCATCTGTTTCCAATTTTTTCGCAAAAAATGTTCAGTCTTAAGAGAGGATCCTGGTTTGAGCTTATCCTCCTGTTCATTTTAAATCTATGCTCTGAGAACCCTCCTGAACAAACAATGCGTGTCTTTTGTGGGATATCAGATAAAAAGTTTAAAAACCCACTTTTCTATTGATCTTACCGCTTTATGTGTGTGCCGCCCAAAAAATGAAAATTTGTTAATTTTTATAGAAGGAACATGTGTTGATTTCGGAGACCGGAGATGGGTG | ||||||
Deletion | ||||||||
PCR_product | ok778_external | |||||||
ok778_internal | ||||||||
SeqStatus | Sequenced | |||||||
Variation_type | Allele | |||||||
Origin (6) | ||||||||
Affects | Gene | WBGene00008239 | ||||||
WBGene00014712 | ||||||||
Transcript | C50H2.1b.1 | VEP_consequence | splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant | |||||
VEP_impact | HIGH | |||||||
HGVSc | C50H2.1b.1:c.263+96_1931delinsGGTGAGCAGCAGGCACAGATAATGTTGAGATAACACCCCTTCAGATCATCACACATCCTTGTTTTTTTCCTTGTTTTCTCACACTCTTCGGTTTCCTTATTTTTTCTGTTCGAAGTGATGTGACATGTCATCTGTTTCCAATTTTTTCGCAAAAAATGTTCAGTCTTAAGAGAGGATCCTGGTTTGAGCTTATCCTCCTGTTCATTTTAAATCTATGCTCTGAGAACCCTCCTGAACAAACAATGCGTGTCTTTTGTGGGATATCAGATAAAAAGTTTAAAAACCCACTTTTCTATTGATCTTACCGCTTTATGTGTGTGCCGCCCAAAAAATGAAAATTTGTTAATTTTTATAGAAGGAACATGTGTTGATTTCGGAGACCGGAGATGGGTG | |||||||
cDNA_position | ?-2054 | |||||||
CDS_position | ?-1931 | |||||||
Protein_position | ?-644 | |||||||
Intron_number | 2-11/14 | |||||||
Exon_number | 3-12/15 | |||||||
C50H2.1a.1 | VEP_consequence | splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant | ||||||
VEP_impact | HIGH | |||||||
HGVSc | C50H2.1a.1:c.263+96_1931delinsGGTGAGCAGCAGGCACAGATAATGTTGAGATAACACCCCTTCAGATCATCACACATCCTTGTTTTTTTCCTTGTTTTCTCACACTCTTCGGTTTCCTTATTTTTTCTGTTCGAAGTGATGTGACATGTCATCTGTTTCCAATTTTTTCGCAAAAAATGTTCAGTCTTAAGAGAGGATCCTGGTTTGAGCTTATCCTCCTGTTCATTTTAAATCTATGCTCTGAGAACCCTCCTGAACAAACAATGCGTGTCTTTTGTGGGATATCAGATAAAAAGTTTAAAAACCCACTTTTCTATTGATCTTACCGCTTTATGTGTGTGCCGCCCAAAAAATGAAAATTTGTTAATTTTTATAGAAGGAACATGTGTTGATTTCGGAGACCGGAGATGGGTG | |||||||
cDNA_position | ?-2052 | |||||||
CDS_position | ?-1931 | |||||||
Protein_position | ?-644 | |||||||
Intron_number | 2-11/14 | |||||||
Exon_number | 3-12/15 | |||||||
C50H2.9 | VEP_consequence | transcript_ablation | ||||||
VEP_impact | HIGH | |||||||
Exon_number | 1/1 | |||||||
Interactor | WBInteraction000050841 | |||||||
WBInteraction000050842 | ||||||||
WBInteraction000503896 | ||||||||
WBInteraction000503897 | ||||||||
WBInteraction000503898 | ||||||||
WBInteraction000503899 | ||||||||
WBInteraction000534831 | ||||||||
WBInteraction000536172 | ||||||||
Isolation | Mutagen | UV/TMP | ||||||
Genetics | Mapping_data | In_multi_point | 5520 | |||||
Description | Phenotype | WBPhenotype:0000460 | Paper_evidence | WBPaper00055106 | ||||
Curator_confirmed | WBPerson712 | |||||||
Remark | An even larger decrease in body bends, from 172.5 to 140.8 body bends/minute, a decrease of 29.2% (p = < 0.0000001) was observed for fshr-1 mutants compared to wild type animals under oxidative stress conditions (Figure 1B). | Paper_evidence | WBPaper00055106 | |||||
Curator_confirmed | WBPerson712 | |||||||
Affected_by | Molecule | WBMol:00002747 | Paper_evidence | WBPaper00055106 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001013 | Paper_evidence | WBPaper00032885 | ||||||
Curator_confirmed | WBPerson495 | |||||||
WBPhenotype:0001620 | Paper_evidence | WBPaper00048530 | ||||||
Curator_confirmed | WBPerson495 | |||||||
Remark | fshr-1(ok778) mutants are sensitive to oxidative stress | Paper_evidence | WBPaper00048530 | |||||
Curator_confirmed | WBPerson495 | |||||||
WBPhenotype:0002378 | Paper_evidence | WBPaper00048530 | ||||||
Curator_confirmed | WBPerson495 | |||||||
Remark | fshr-1(ok778) mutants are impaired in their ability to avoid PA14 | Paper_evidence | WBPaper00048530 | |||||
Curator_confirmed | WBPerson495 | |||||||
Phenotype_not_observed | WBPhenotype:0000114 | Paper_evidence | WBPaper00035891 | |||||
Curator_confirmed | WBPerson2987 | |||||||
Remark | "We also tested the role of several other pathways implicated in C. elegans immunity, including the TGF-beta pathway, JNK pathway, the G protein-coupled receptor fshr-1, and the betacatenin homolog bar-1. None of the pathways we tested appeared to be required for induction of irg-1 (see SI Text and Fig S1)." | Paper_evidence | WBPaper00035891 | |||||
Curator_confirmed | WBPerson2987 | |||||||
Reference | WBPaper00035891 | |||||||
WBPaper00032885 | ||||||||
WBPaper00048530 | ||||||||
WBPaper00055106 | ||||||||
WBPaper00065640 | ||||||||
Remark | Sequenced by the C. elegans Gene Knockout Consortium | Paper_evidence | WBPaper00041807 | |||||
Method | KO_consortium_allele |