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WormBase Tree Display for Variation: WBVar00091811

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Name Class

WBVar00091811NamePublic_nameok524
Other_nameT01C8.1c.1:c.301_591-57del
T01C8.1b.1:c.487_777-57del
T01C8.1a.1:c.487_777-57del
HGVSgCHROMOSOME_X:g.16800225_16800632del
Sequence_detailsSMapS_parentSequenceT01C8
Flanking_sequencesgtcatcagtacaccttctgacattttcatgtagaaatccaattaaagtaattgaacaaga
Mapping_targetT01C8
Type_of_mutationDeletion
PCR_productOK524_external
OK524_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00000096
WBStrain00007674
WBStrain00007693
WBStrain00026437
WBStrain00026544
WBStrain00030637
WBStrain00031468
WBStrain00034665
WBStrain00056770
LaboratoryRB
EN
PersonWBPerson46
KO_consortium_allele
StatusLive
AffectsGeneWBGene00020142
TranscriptT01C8.1b.1VEP_consequencesplice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScT01C8.1b.1:c.487_777-57del
cDNA_position487-?
CDS_position487-?
Protein_position163-?
Intron_number3/10
Exon_number3/11
T01C8.1c.1VEP_consequencesplice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScT01C8.1c.1:c.301_591-57del
cDNA_position344-?
CDS_position301-?
Protein_position101-?
Intron_number3/10
Exon_number3/11
T01C8.1a.1VEP_consequencesplice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScT01C8.1a.1:c.487_777-57del
cDNA_position489-?
CDS_position487-?
Protein_position163-?
Intron_number4/11
Exon_number4/12
Interactor (39)
IsolationMutagenUV/TMP
GeneticsMapping_dataIn_multi_point5059
DescriptionPhenotype (22)
Phenotype_not_observedWBPhenotype:0000039Paper_evidenceWBPaper00041842
WBPaper00049105
Curator_confirmedWBPerson2987
RemarkTable 2; note that this conflicts with data in Table SIII reporting that aak-2(ok524) results in a significantly reduced life spanPaper_evidenceWBPaper00041842
Curator_confirmedWBPerson2987
"To test a function of mitochondrial stress signaling in tumor survival during starvation, we used mutants in this signaling pathway, prdx-2(gk169) and aak-2(ok425). After induction of tumor formation by gld-1 RNAi, we performed life span analysis either under feeding (aak-2 and prdx-2; Figure 9B and S6A) or starvation conditions (aak-2 only; Figs 9C and S6B)... Notably, life span under feeding in animals with tumors depends on both aak-2 and prdx-2 function (Fig 9B), whereas starvation-induced life span extension is not affected in the aak-2 mutant (Fig 9C), consistent with recent findings."Paper_evidenceWBPaper00049105
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentFasting conditionsPaper_evidenceWBPaper00049105
Curator_confirmedWBPerson2987
Genotypegld-1(RNAi)Paper_evidenceWBPaper00049105
Curator_confirmedWBPerson2987
WBPhenotype:0000114Paper_evidenceWBPaper00045372
Curator_confirmedWBPerson2987
RemarkmRNA levels of tph-1 and aak-1 (Figure S3), as well as daf-7, daf-28, and ser-5 (Figure S7B) were not affected by the aak-2(ok524) mutationPaper_evidenceWBPaper00045372
Curator_confirmedWBPerson2987
WBPhenotype:0000876Paper_evidenceWBPaper00032396
Curator_confirmedWBPerson2987
Remarkaak-2(ok524) animals do not exhibit changes in response to osmotic stress (high concentrations of sodium chloride (NaCl)) compared to wild type controls (Figure 3a)Paper_evidenceWBPaper00032396
Curator_confirmedWBPerson2987
aak-2(ok524) animals do not exhibit changes in response to osmotic stress (high concentrations of sodium chloride (NaCl)) in a daf-2(e1370) mutant background (Figure 3a)Paper_evidenceWBPaper00032396
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00003571Paper_evidenceWBPaper00032396
Curator_confirmedWBPerson2987
Phenotype_assayGenotypedaf-2(e1370)Paper_evidenceWBPaper00032396
Curator_confirmedWBPerson2987
Reference (18)
RemarkSequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele