WormBase Tree Display for Gene: WBGene00020142
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| WBGene00020142 | SMap | S_parent | Sequence | T01C8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | aak-2 | Paper_evidence | WBPaper00024628 | |||||
| Sequence_name | T01C8.1 | ||||||||
| Molecular_name | T01C8.1a | ||||||||
| T01C8.1a.1 | |||||||||
| CE31222 | |||||||||
| T01C8.1b | |||||||||
| CE31223 | |||||||||
| T01C8.1c | |||||||||
| CE07458 | |||||||||
| T01C8.1b.1 | |||||||||
| T01C8.1c.1 | |||||||||
| Other_name | AMPK | Paper_evidence | WBPaper00035954 | ||||||
| CELE_T01C8.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | aak-2 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:02 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 25 Jan 2005 16:32:44 | WBPerson2970 | Name_change | CGC_name | aak-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | aak | ||||||||
| Allele (112) | |||||||||
| Possibly_affected_by | WBVar02157821 | ||||||||
| WBVar02157822 | |||||||||
| Strain (12) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (29) | |||||||||
| Ortholog (39) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | aak-2 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); in C. elegans, aak-2 functions downstream of environmental stressors, energy level signals (AMP:ATP ratio), and daf-2-mediated insulin signaling to positively regulate adult lifespan; in regulating lifespan, aak-2 likely acts in parallel with daf-16/FOXO; aak-2 activity is also required for dauer formation in daf-2 mutant animals at high temperature in a manner independent of the AMP:ATP ratio; in the germline, aak-2 functions downstream of daf-2 and daf-7, and in parallel to par-4 and aak-1, to negatively regulate germline proliferation during dauer development; in vitro, AAK-2 exhibits AMP-enhanced kinase activity against a known AMPK substrate, the SAMS peptide. | Paper_evidence | WBPaper00024886 | |||||
| WBPaper00027027 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 08 Mar 2006 00:00:00 | ||||||||
| Automated_description | Enables AMP-activated protein kinase activity. Involved in several processes, including determination of adult lifespan; pharyngeal pumping; and regulation of protein secretion. Located in axon; cytoplasm; and neuronal cell body. Expressed in several structures, including body wall musculature; excretory canal; interfacial epithelial cell; neurons; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; colon cancer; and type 2 diabetes mellitus. Is an ortholog of human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1) and PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9376) | ||||
| DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9376) | ||||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9377) | ||||||
| DOID:219 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9376) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9376) | ||||||
| Molecular_info | Corresponding_CDS | T01C8.1a | |||||||
| T01C8.1b | |||||||||
| T01C8.1c | |||||||||
| Corresponding_transcript | T01C8.1a.1 | ||||||||
| T01C8.1b.1 | |||||||||
| T01C8.1c.1 | |||||||||
| Other_sequence (78) | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result (34) | ||||||||
| Expr_pattern (15) | |||||||||
| Drives_construct (17) | |||||||||
| Construct_product (28) | |||||||||
| Regulate_expr_cluster | WBPaper00038118:aak-2(gt33)_downregulated | ||||||||
| WBPaper00038118:aak-2(gt33)_upregulated | |||||||||
| WBPaper00038172:aak-2overexpression_down_regulated | |||||||||
| WBPaper00038172:aak-2overexpression_up_regulated | |||||||||
| WBPaper00046499:AMPK_regulated | |||||||||
| WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated | |||||||||
| WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated | |||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (133) | |||||||||
| Interaction (171) | |||||||||
| Anatomy_function | WBbtf0654 | ||||||||
| WBbtf0655 | |||||||||
| WBbtf0658 | |||||||||
| WBProcess | WBbiopr:00000121 | ||||||||
| Map_info | Map | X | Position | 24.0613 | Error | 0.00069 | |||
| Positive | Positive_clone | T01C8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5059 | |||||||
| 4398 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (233) | |||||||||
| Picture | WBPicture0000013096 | ||||||||
| WBPicture0000013098 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
