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WormBase Tree Display for Variation: WBVar00091497

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Name Class

WBVar00091497EvidencePaper_evidenceWBPaper00004723
NamePublic_nameok186
Other_nameF33D4.1a.1:c.564+20_1533del
F33D4.1b.1:c.561+23_1530del
HGVSgCHROMOSOME_IV:g.7712653_7714019del
Sequence_detailsSMapS_parentSequenceF33D4
Flanking_sequencescaacagctgtggttagtagagtttaaaataggtaaatcacgtgctgacattgcatacagt
Mapping_targetF33D4
Type_of_mutationDeletion
PCR_productok186_external
ok186_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00000059
LaboratoryRB
PersonWBPerson46
KO_consortium_allele
StatusLive
AffectsGeneWBGene00171604
WBGene00003607
TranscriptF33D4.10
F33D4.1b.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScF33D4.1b.1:c.561+23_1530del
cDNA_position?-1691
CDS_position?-1530
Protein_position?-510
Intron_number5-9/10
Exon_number6-10/11
F33D4.1a.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScF33D4.1a.1:c.564+20_1533del
cDNA_position?-1699
CDS_position?-1533
Protein_position?-511
Intron_number5-9/10
Exon_number6-10/11
InteractorWBInteraction000543106
WBInteraction000543107
WBInteraction000557017
WBInteraction000564464
GeneticsMapping_dataIn_multi_point4520
DescriptionPhenotypeWBPhenotype:0000033Paper_evidenceWBPaper00051068
Curator_confirmedWBPerson7188
RemarkFigure 3. Population density-dependent acceleration of development (Pdda) is increased.Paper_evidenceWBPaper00051068
Curator_confirmedWBPerson7188
Figure 3. Worms do not respond to population density-dependent acceleration of development (Pdda)Paper_evidenceWBPaper00051068
Curator_confirmedWBPerson7188
WBPhenotype:0000486Paper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
Remarknhr-8(ok186) homozygotes are more sensitive than wild-type animals to the toxins colchicinePaper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
Phenotype_assayTreatment0-3.5 mM ColchicinePaper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
WBPhenotype:0000488Paper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
Remarknhr-8(ok186) homozygotes are more sensitive than wild-type animals to the toxin chloroquinePaper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
Affected_byMoleculeWBMol:00001530Paper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
Phenotype_assayTreatment0-8 mM chloroquinePaper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
WBPhenotype:0001013Paper_evidenceWBPaper00059728
Curator_confirmedWBPerson49407
Remark(Figure 3E-I, S7) This mutant was more exhibited increase susceptibility to pathogen compared to N2 control animalsPaper_evidenceWBPaper00059728
Curator_confirmedWBPerson49407
WBPhenotype:0001739Paper_evidenceWBPaper00045724
Curator_confirmedWBPerson4671
Remarkunable to respond to dietary restrictionPaper_evidenceWBPaper00045724
Curator_confirmedWBPerson4671
WBPhenotype:0001973Paper_evidenceWBPaper00045724
Curator_confirmedWBPerson4671
RemarkLarge amount of germ cells in the transition zone upon dietary restrictionPaper_evidenceWBPaper00045724
Curator_confirmedWBPerson4671
Phenotype_not_observedWBPhenotype:0000062Paper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
RemarkHomozygous nhr-8(ok186) animals are viablePaper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
WBPhenotype:0000114Paper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
Remarkpgp-3 mRNA levels are not dramatically altered in nhr-8(ok186) mutantsPaper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
WBPhenotype:0001013Paper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
Remarknhr-8(ok186), animals are not more sensitive than wild-type to Pseudomonas aeruginosaPaper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
Phenotype_assayTreatment6 hr of exposure to the PA14 strain of P. aeruginosaPaper_evidenceWBPaper00004723
Curator_confirmedWBPerson2021
WBPhenotype:0001838Paper_evidenceWBPaper00031850
Curator_confirmedWBPerson2987
RemarkThe gene expression toxin response to fluoranthene and beta-naphtoflavone at the L4 larval stage is largely unaffected by the nhr-8(ok186) mutation (Table S8, Figure S3C).Paper_evidenceWBPaper00031850
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00004956Paper_evidenceWBPaper00031850
Curator_confirmedWBPerson2987
WBMol:00001621Paper_evidenceWBPaper00031850
Curator_confirmedWBPerson2987
ReferenceWBPaper00031850
WBPaper00004723
WBPaper00045724
WBPaper00051068
WBPaper00059728
RemarkLast updated on 29 Nov 2002
Knockout originally requested for F33D4.1 before it was renamed to F33D4.1a/b
Sequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele