WormBase Tree Display for Variation: WBVar00090969

WBVar00090969 Evidence: Paper_evidence: WBPaper00005368
  Name: Public_name: ne299
    Other_name: CE00630:p.Glu122AspfsTer7
      T20G5.11.1:c.365_366insT
    HGVSg: CHROMOSOME_III:g.10218279_10218280insA
  Sequence_details: SMap: S_parent: Sequence: T20G5
    Flanking_sequences: ctttttcattcctggaacaaccaaagaaga agctctttcgaatatgtaatgctttcaagt
    Mapping_target: T20G5
    Type_of_mutation: Insertion: t
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00000440
      WBStrain00000442
    Laboratory: WM
    Status: Live
  Affects: Gene: WBGene00004326
    Transcript: T20G5.11.1 VEP_consequence: frameshift_variant
        VEP_impact: HIGH
        HGVSc: T20G5.11.1:c.365_366insT
        HGVSp: CE00630:p.Glu122AspfsTer7
        cDNA_position: 367-368
        CDS_position: 365-366
        Protein_position: 122
        Exon_number: 2/6
        Codon_change: gaa/gaTa
        Amino_acid_change: E/DX
    Interactor: WBInteraction000505050
  Genetics: Interpolated_map_position: III 2.02008
  Description: Phenotype: WBPhenotype:0000032 Paper_evidence: WBPaper00044603
        Curator_confirmed: WBPerson712
        Remark: animals are sick Paper_evidence: WBPaper00044603
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: mgIs30 Paper_evidence: WBPaper00044603
              Curator_confirmed: WBPerson712
      WBPhenotype:0000743 Paper_evidence: WBPaper00044603
        Curator_confirmed: WBPerson712
        Remark: sick Paper_evidence: WBPaper00044603
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: mgIs30 Paper_evidence: WBPaper00044603
              Curator_confirmed: WBPerson712
      WBPhenotype:0001208 Paper_evidence: WBPaper00003711
        Curator_confirmed: WBPerson557
        Remark: Animals showed strong resistance to RNAi. Paper_evidence: WBPaper00003711
            Curator_confirmed: WBPerson557
      WBPhenotype:0001595 Paper_evidence: WBPaper00025011
        Curator_confirmed: WBPerson3423
    Phenotype_not_observed: WBPhenotype:0000033 Paper_evidence: WBPaper00026761
        Curator_confirmed: WBPerson712
        Remark: These worms display no obvious let-7-like heterochronic phenotypes. Paper_evidence: WBPaper00026761
            Curator_confirmed: WBPerson712
      WBPhenotype:0000136 Paper_evidence: WBPaper00026761
        Curator_confirmed: WBPerson712
        Remark: No apparent differences from wild-type in lin-41 mRNA regulation were detected in RNA collected from rde-4(ne299) mutant worms, which are fully RNAi defective. Paper_evidence: WBPaper00026761
            Curator_confirmed: WBPerson712
      WBPhenotype:0000743 Paper_evidence: WBPaper00044603
        Curator_confirmed: WBPerson712
        Remark: Transgene expression is wild-type Paper_evidence: WBPaper00044603
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: mgIs30 Paper_evidence: WBPaper00044603
              Curator_confirmed: WBPerson712
      WBPhenotype:0000745 Paper_evidence: WBPaper00003711
        Curator_confirmed: WBPerson557
      WBPhenotype:0001175 Paper_evidence: WBPaper00003711
        Curator_confirmed: WBPerson557
  Reference: WBPaper00005368
    WBPaper00026761
    WBPaper00025011
    WBPaper00044603
    WBPaper00003711
  Remark: This T insertion creates a premature stop codon Paper_evidence: WBPaper00005368
  Method: Insertion_allele