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WormBase Tree Display for Variation: WBVar00090963

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WBVar00090963	Evidence	Paper_evidence	WBPaper00003711
	Name	Public_name	ne219
		Other_name	CE28243:p.Glu414Lys
			K08H10.7.1:c.1240G>A
		HGVSg	CHROMOSOME_V:g.9990087C>T
	Sequence_details	SMap	S_parent	Sequence	K08H10
		Flanking_sequences	aagtggagcaaaagaatacgctgtaccaatg	aacatcttgaagttcatgagaagccacaaag
		Mapping_target	K08H10
		Type_of_mutation	Substitution	g	a	Paper_evidence	WBPaper00003711
		SeqStatus	Sequenced
	Variation_type	Allele
	Origin	Species	Caenorhabditis elegans
		Strain (42)
		Laboratory	WM
			NR
			SHU
			VP
			MBA
		Status	Live
	Affects	Gene	WBGene00004323
		Transcript	K08H10.7.1 (12)
	Genetics	Interpolated_map_position	V	2.22831
		Mapping_data	In_multi_point	4628
	Description	Phenotype	WBPhenotype:0001208	Paper_evidence	WBPaper00030899
					WBPaper00003711
				Curator_confirmed	WBPerson712
					WBPerson557
				Remark	Animals showed strong resistance to RNAi.	Paper_evidence	WBPaper00003711
						Curator_confirmed	WBPerson557
			WBPhenotype:0002252	Paper_evidence	WBPaper00038088
				Curator_confirmed	WBPerson172
				Remark	Figure 7	Paper_evidence	WBPaper00038088
						Curator_confirmed	WBPerson172
		Phenotype_not_observed	WBPhenotype:0000745	Paper_evidence	WBPaper00003711
				Curator_confirmed	WBPerson557
			WBPhenotype:0001175	Paper_evidence	WBPaper00003711
				Curator_confirmed	WBPerson557
			WBPhenotype:0001258	Paper_evidence	WBPaper00035199
				Curator_confirmed	WBPerson712
			WBPhenotype:0001594	Paper_evidence	WBPaper00003711
				Curator_confirmed	WBPerson557
			WBPhenotype:0001759	Paper_evidence	WBPaper00031962
					WBPaper00035199
				Curator_confirmed	WBPerson712
				Remark	Levels of 21U-RNA, from Nothern blot or from qRT-PRC, were comparable to that of wild-type.	Paper_evidence	WBPaper00031962
						Curator_confirmed	WBPerson712
					Animals retain the ability to express this class of small regulatory RNAs.	Paper_evidence	WBPaper00035199
						Curator_confirmed	WBPerson712
				EQ_annotations	GO_term	GO:0034585	PATO:0000460	Paper_evidence	WBPaper00031962
								Curator_confirmed	WBPerson712
			WBPhenotype:0001769	Paper_evidence	WBPaper00032049
				Curator_confirmed	WBPerson712
				Remark	Cytoplasmic-localized RNAs were susceptible to silencing.	Paper_evidence	WBPaper00032049
						Curator_confirmed	WBPerson712
				Phenotype_assay	Treatment	Animals were fed bacteria expressing dsRNAs.	Paper_evidence	WBPaper00032049
							Curator_confirmed	WBPerson712
					Genotype	eri-1(mg366)	Paper_evidence	WBPaper00032049
							Curator_confirmed	WBPerson712
			WBPhenotype:0001776	Paper_evidence	WBPaper00035199
				Curator_confirmed	WBPerson712
				Remark	Animals express endo siRNAs.	Paper_evidence	WBPaper00035199
						Curator_confirmed	WBPerson712
			WBPhenotype:0001778	Paper_evidence	WBPaper00032049
				Curator_confirmed	WBPerson712
				Remark	Nuclear-localized RNAs were susceptible to silencing.	Paper_evidence	WBPaper00032049
						Curator_confirmed	WBPerson712
				Phenotype_assay	Treatment	Animals were fed bacteria expressing dsRNAs.	Paper_evidence	WBPaper00032049
							Curator_confirmed	WBPerson712
					Genotype	eri-1(mg366)	Paper_evidence	WBPaper00032049
							Curator_confirmed	WBPerson712
			WBPhenotype:0001779	Paper_evidence	WBPaper00035199
				Curator_confirmed	WBPerson712
				Remark	Animals retain the ability to express this class of small regulatory RNAs.	Paper_evidence	WBPaper00035199
						Curator_confirmed	WBPerson712
			WBPhenotype:0002168	Paper_evidence	WBPaper00045092
				Curator_confirmed	WBPerson712
				Remark	rde-1 mutants were similar to wildtype animals in terms of fertility at generation 10.	Paper_evidence	WBPaper00045092
						Curator_confirmed	WBPerson712
	Reference (18)
	Method	Substitution_allele