WormBase Tree Display for Variation: WBVar00090305

WBVar00090305 Evidence: Paper_evidence: WBPaper00001952
  Name: Public_name: n1950
    Other_name: T07C4.8.1:c.506G>A
      CE25104:p.Gly169Glu
    HGVSg: CHROMOSOME_III:g.10335725G>A
  Sequence_details: SMap: S_parent: Sequence: T07C4
    Flanking_sequences: cacagacagatcaatgtccaatgtcttatg acgtttggtaagggagaaaatactgaaaaa
    Mapping_target: T07C4
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00001952
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00027154
      WBStrain00027218
    Laboratory: MT
    Status: Live
  Linked_to: WBVar00090306
    WBVar00090307
  Affects: Gene: WBGene00000423
    Transcript: T07C4.8.1 (12)
    Interactor: WBInteraction000001555
      WBInteraction000001629
      WBInteraction000051724
      WBInteraction000052048
      WBInteraction000500984
      WBInteraction000521674
      WBInteraction000521794
      WBInteraction000525163
      WBInteraction000562577
      WBInteraction000571525
  Genetics: Interpolated_map_position: III 2.35521
    Mapping_data: In_multi_point: 1808
        1809
        1810
        1811
        1812
        1813
        1814
        1815
        1816
        1819
  Description: Phenotype (14)
    Phenotype_not_observed: WBPhenotype:0001401 Paper_evidence: WBPaper00032231
          WBPaper00033026
        Curator_confirmed: WBPerson712
          WBPerson2021
        Remark: Mean mitochondrial length was similar to control animals, although the diameter of mitochondria occasionally appeared slightly larger than those of other genotypes. Trasmission EM analysis did not reveal any gross mitochondrial abnormalities in body wall muscle or hypodermis. Paper_evidence: WBPaper00032231
            Curator_confirmed: WBPerson712
          Mitochondria in mutant embryos embryos appeared similar to those observed in N2 embryos. Mitochondria in the germline, gut, and muscle cells of adult egl-1(lf), ced-9(lf); ced-3(lf), or ced-9(gf) mutants also appeared to be normal Paper_evidence: WBPaper00033026
            Curator_confirmed: WBPerson2021
        Semi_dominant: Paper_evidence: WBPaper00032231
          Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00032231
              WBPaper00033026
            Curator_confirmed: WBPerson712
              WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0005772 PATO:0000460 Paper_evidence: WBPaper00033026
                Curator_confirmed: WBPerson2021
            WBbt:0003675 PATO:0000460 Paper_evidence: WBPaper00033026
                Curator_confirmed: WBPerson2021
            WBbt:0005784 PATO:0000460 Paper_evidence: WBPaper00033026
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00033026
                Curator_confirmed: WBPerson2021
            WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00033026
                Curator_confirmed: WBPerson2021
          GO_term: GO:0005739 PATO:0000460 Paper_evidence: WBPaper00032231
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Young adults were stained with Mito Tracker Red CMXRos. Paper_evidence: WBPaper00032231
              Curator_confirmed: WBPerson712
      WBPhenotype:0001426 Paper_evidence: WBPaper00004883
        Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: arIs37 Paper_evidence: WBPaper00004883
              Curator_confirmed: WBPerson712
      WBPhenotype:0001650 Paper_evidence: WBPaper00031571
        Curator_confirmed: WBPerson712
        Remark: Germ cells of animals are condensed and unhealthy like that of germs cells in wild type animals grown on 5-FU. Paper_evidence: WBPaper00031571
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Animals were grown on plates containing 400nM 5-FU for 12 hours from late L4 stage. Paper_evidence: WBPaper00031571
              Curator_confirmed: WBPerson712
      WBPhenotype:0001651 Paper_evidence: WBPaper00031571
        Curator_confirmed: WBPerson712
        Remark: Animals did not progress to L4 (data not shown). Paper_evidence: WBPaper00031571
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Embryos were transferred to plates containing 5-FU and remaining larva were counted after 72 hours. Paper_evidence: WBPaper00031571
              Curator_confirmed: WBPerson712
      WBPhenotype:0001851 Paper_evidence: WBPaper00027700
        Curator_confirmed: WBPerson2021
        Remark: Mutants did not display significant radiosensitivity when compared with WT N2 C. elegans Paper_evidence: WBPaper00027700
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006748 PATO:0000460 Paper_evidence: WBPaper00027700
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00027700
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 100-400 Gy radiation Paper_evidence: WBPaper00027700
              Curator_confirmed: WBPerson2021
  Reference (30)
  Method: Substitution_allele