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WormBase Tree Display for Variation: WBVar00090232

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Name Class

WBVar00090232EvidencePaper_evidenceWBPaper00035332
NamePublic_namen1653
Other_nameT07C4.8.1:c.445T>A
CE25104:p.Tyr149Asn
HGVSgCHROMOSOME_III:g.10335664T>A
Sequence_detailsSMapS_parentSequenceT07C4
Flanking_sequencesctcgcagtgcccagaatctcattttcactgatcaggatgtggttcggacggttggaaatg
Mapping_targetT07C4
Type_of_mutationSubstitutiontaPaper_evidenceWBPaper00035332
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00024084
WBStrain00027104
LaboratoryMT
StatusLive
AffectsGeneWBGene00000423
TranscriptT07C4.8.1 (12)
GeneticsInterpolated_map_positionIII2.35497
DescriptionPhenotypeWBPhenotype:0000006Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
WBPhenotype:0000121Paper_evidenceWBPaper00049178
Curator_confirmedWBPerson712
RemarkWhen the function of Bcl-2 was abrogated in the ced-9ts strain, the distribution of gpd-3 mRNA among polysomes broadened, but the median of the message distribution mirrored that of the wild type strain (Fig. 3E). The ced-9ts strain showed consistent, modest increases in hsp-3 mRNA translational efficiency (Fig. 3F-G).This increase is significant due to the overall shift of the mRNA density into the more efficiently translating fractions near the bottom of the gradient. There was o change in the efficiency of hsp-4 translation in ced-9ts worms (Fig. 3I) relative to wild type. ced-4 mRNA underwent a significant decrease in translational efficiency in the ced-9ts (Fig. 5H) strain.Paper_evidenceWBPaper00049178
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00049178
Curator_confirmedWBPerson712
WBPhenotype:0000930Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
RemarkThe sexual fates of multiple sexually dimorphic cells are alteredPaper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
WBPhenotype:0001172Paper_evidenceWBPaper00004574
Curator_confirmedWBPerson712
Remarkced-9(n1653ts) loss-of-function mutant exhibited elevated PCD in the gonads (data not shown).Paper_evidenceWBPaper00004574
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005175PATO:0000460Paper_evidenceWBPaper00004574
Curator_confirmedWBPerson712
WBPhenotype:0001180Paper_evidenceWBPaper00040175
WBPaper00049178
Curator_confirmedWBPerson712
RemarkGrowth of ced-9ts young adult worms at 25 deg C for 36h caused accumulation of numerous germ cell corpses decorated with ced-1::GFP fluorescence.Paper_evidenceWBPaper00040175
Curator_confirmedWBPerson712
The ced-9ts strain showed a significant increase in apoptotic corpses in the young adult stages (24-48h) that mirrored the changes observed in the ifg-1::mos strain.Paper_evidenceWBPaper00049178
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00040175
Curator_confirmedWBPerson712
Phenotype_assayGenotypemab-5(mu114)Paper_evidenceWBPaper00049178
Curator_confirmedWBPerson712
WBPhenotype:0001220Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
RemarkHSNs undergo embryonic apoptosis in hermaphrodites.Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0006830PATO:0000460Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
WBPhenotype:0001355Paper_evidenceWBPaper00040175
Curator_confirmedWBPerson712
RemarkThe young gonad showed normal morphology of surrounding early and late-staged oocytes and the organ as a whole.Paper_evidenceWBPaper00040175
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00040175
Curator_confirmedWBPerson712
WBPhenotype:0001645Paper_evidenceWBPaper00040175
Curator_confirmedWBPerson712
RemarkBiochemical analysis of IFG-1 p170 by western blot, revealed that these worms accumulate N-terminal cleavage products.Paper_evidenceWBPaper00040175
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00040175
Curator_confirmedWBPerson712
WBPhenotype:0001807Paper_evidenceWBPaper00049178
Curator_confirmedWBPerson712
RemarkImportantly, the activation of the caspase, CED-3, in the ced-9ts strain causes IFG-1 p170 cleavage to a p130-like product, perhaps promoting a similar out come to the ifg-1::mos allele.Paper_evidenceWBPaper00049178
Curator_confirmedWBPerson712
Phenotype_assayGenotypemab-5(mu114)Paper_evidenceWBPaper00049178
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000062Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkWeak loss of function, viable.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000691Paper_evidenceWBPaper00049178
Curator_confirmedWBPerson712
Remarkstrains showed normally developed gonads with a typical linearprogression of developing germ cells that mature into oocytesPaper_evidenceWBPaper00049178
Curator_confirmedWBPerson712
Phenotype_assayGenotypemab-5(mu114)Paper_evidenceWBPaper00049178
Curator_confirmedWBPerson712
WBPhenotype:0001012Paper_evidenceWBPaper00004574
Curator_confirmedWBPerson712
RemarkThe ced-9(n1653ts) mutant had a short lifespan when feeding on S. typhimurium and a short lifespan when feeding on E. coli. Therefore, the relative mortality of ced-9 worms feeding on S. typhimurium was not significantly different from control wild-type worms.Paper_evidenceWBPaper00004574
Curator_confirmedWBPerson712
WBPhenotype:0001401Paper_evidenceWBPaper00033026
WBPaper00035144
Curator_confirmedWBPerson2021
RemarkMitochondria in mutant embryos embryos appeared similar to those observed in N2 embryos. Mitochondria in the germline, gut, and muscle cells of adult egl-1(lf), ced-9(lf); ced-3(lf), or ced-9(gf) mutants also appeared to be normalPaper_evidenceWBPaper00033026
Curator_confirmedWBPerson2021
No defects in mitochondrial morphology in ced-9(n1653ts) embryos at the nonpermissive temperaturePaper_evidenceWBPaper00035144
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0005772PATO:0000460Paper_evidenceWBPaper00033026
Curator_confirmedWBPerson2021
WBbt:0003675PATO:0000460Paper_evidenceWBPaper00033026
Curator_confirmedWBPerson2021
WBbt:0005784PATO:0000460Paper_evidenceWBPaper00033026
Curator_confirmedWBPerson2021
Life_stageWBls:0000003PATO:0000460Paper_evidenceWBPaper00033026
Curator_confirmedWBPerson2021
WBls:0000041PATO:0000460Paper_evidenceWBPaper00033026
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00033026
WBPaper00035144
Curator_confirmedWBPerson2021
ReferenceWBPaper00040175
WBPaper00021826
WBPaper00004574
WBPaper00035332
WBPaper00033026
WBPaper00035144
WBPaper00001105
WBPaper00049178
MethodSubstitution_allele