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WormBase Tree Display for Variation: WBVar00089950

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WBVar00089950	Name	Public_name	n1084n3082
	Sequence_details	SeqStatus	Pending_curation
	Variation_type	Allele
	Origin	Species	Caenorhabditis elegans
		Laboratory	MT
		Status	Live
	Linked_to	WBVar00089949
		WBVar00090654
	Affects	Gene	WBGene00001170
		Interactor	WBInteraction000000911
			WBInteraction000052002
			WBInteraction000052003
			WBInteraction000052004
			WBInteraction000052049
			WBInteraction000521747
			WBInteraction000521748
			WBInteraction000525167
	Genetics	Mapping_data	In_multi_point	3962
	Description	Phenotype	WBPhenotype:0000184	Paper_evidence	WBPaper00031670
				Curator_confirmed	WBPerson712
				Remark	Many apoptotic events failed to occur, including the death of NSM sister cells.	Paper_evidence	WBPaper00031670
						Curator_confirmed	WBPerson712
				Variation_effect	Probable_null_via_phenotype	Paper_evidence	WBPaper00031670
						Curator_confirmed	WBPerson712
				EQ_annotations	Anatomy_term	WBbt:0003666	PATO:0000460	Paper_evidence	WBPaper00031670
								Curator_confirmed	WBPerson712
			WBPhenotype:0001268	Paper_evidence	WBPaper00032243
				Curator_confirmed	WBPerson712
				Remark	The number of germ cell corpses per gonad arm was not changed above control levels after administration of 1uM ceramide.	Paper_evidence	WBPaper00032243
						Curator_confirmed	WBPerson712
				Variation_effect	Probable_null_via_phenotype	Paper_evidence	WBPaper00032243
						Curator_confirmed	WBPerson712
				Affected_by	Molecule	WBMol:00004926	Paper_evidence	WBPaper00032243
							Curator_confirmed	WBPerson712
				EQ_annotations	Anatomy_term	WBbt:0005175	PATO:0000460	Paper_evidence	WBPaper00032243
								Curator_confirmed	WBPerson712
				Phenotype_assay	Treatment	1uM C16-ceramide was microinjected into the gonad.	Paper_evidence	WBPaper00032243
							Curator_confirmed	WBPerson712
			WBPhenotype:0001270	Paper_evidence	WBPaper00004574
				Curator_confirmed	WBPerson712
				Remark	The egl-1(n1084n3082) loss-of-function mutant also exhibited a reduction in Salmonella-induced germ-line apoptosis compared with wild-type N2 worms.	Paper_evidence	WBPaper00004574
						Curator_confirmed	WBPerson712
				EQ_annotations	Anatomy_term	WBbt:0005784	PATO:0000460	Paper_evidence	WBPaper00004574
								Curator_confirmed	WBPerson712
			WBPhenotype:0001271	Paper_evidence	WBPaper00004574
				Curator_confirmed	WBPerson712
				Remark	Mutants were more susceptible to Salmonella-mediated killing.	Paper_evidence	WBPaper00004574
						Curator_confirmed	WBPerson712
				Variation_effect	Loss_of_function_undetermined_extent	Paper_evidence	WBPaper00004574
						Curator_confirmed	WBPerson712
			WBPhenotype:0001620	Paper_evidence	WBPaper00053621
				Curator_confirmed	WBPerson28450
			WBPhenotype:0001621	Paper_evidence	WBPaper00053621
				Curator_confirmed	WBPerson28450
			WBPhenotype:0001756	Paper_evidence	WBPaper00029176
				Curator_confirmed	WBPerson557
				Remark	UV-C-induced germ cell apoptosis was abrogated in egl-1(n1084n3082) mutants.	Paper_evidence	WBPaper00029176
						Curator_confirmed	WBPerson557
				Phenotype_assay	Treatment	Germ cell apoptosis was measured following exposure to 100 joules per square meter UV-C.	Paper_evidence	WBPaper00029176
							Curator_confirmed	WBPerson557
		Phenotype_not_observed	WBPhenotype:0001585	Paper_evidence	WBPaper00031670
				Curator_confirmed	WBPerson712
				Remark	On average in wild-type animals, NSM sister cell is 0.46 times the size of NSM, whereas it was 0.52 in n1084n3082 animals.	Paper_evidence	WBPaper00031670
						Curator_confirmed	WBPerson712
				Variation_effect	Probable_null_via_phenotype	Paper_evidence	WBPaper00031670
						Curator_confirmed	WBPerson712
				EQ_annotations	Anatomy_term	WBbt:0003666	PATO:0000460	Paper_evidence	WBPaper00031670
								Curator_confirmed	WBPerson712
				Phenotype_assay	Genotype	tIs38 [pie-1::gfp::ph(PLC1delta1)]	Paper_evidence	WBPaper00031670
							Curator_confirmed	WBPerson712
	Reference	WBPaper00004574
		WBPaper00032243
		WBPaper00031670
		WBPaper00053621
		WBPaper00029176
	Remark	Cis double mutant
	Method	Allele