WormBase Tree Display for Variation: WBVar00089949

WBVar00089949 Name: Public_name: n1084
    Other_name: n487 Paper_evidence: WBPaper00003631
      n1796 Paper_evidence: WBPaper00003631
  Sequence_details: SMap: S_parent: Sequence: VF23B12L
    Flanking_sequences: TATTGGGTATTGTTTACTCCTAACCGGGTG TCCATAAAATTCTATTGTCCCAGATTTAGG
    Mapping_target: VF23B12L
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00003631
            Person_evidence: WBPerson117
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00026954
      WBStrain00027341
    Laboratory: MT
    Status: Live
  Linked_to: WBVar00089950
  Affects: Gene: WBGene00001170
  Genetics: Interpolated_map_position: V 6.30574
  Description: Phenotype: WBPhenotype:0000006 Paper_evidence: WBPaper00001133
        Curator_confirmed: WBPerson2021
        Remark: The penetrance of the egg-laying defect in n1084 heterozygotes is heat-sensitive. See Table 7 Paper_evidence: WBPaper00001133
            Curator_confirmed: WBPerson2021
        Penetrance: High: As shown in Table 5, 74 percent of heterozygotes are Egl. Under homozygous conditions, 98 percent of hermaphrodites are Egl Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
        Dominant: Paper_evidence: WBPaper00001133
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 20 Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000154 Paper_evidence: WBPaper00001133
        Curator_confirmed: WBPerson2021
        Remark: Mutants show a 37 percent drop in brood size (compared to wild-type) Paper_evidence: WBPaper00001133
            Curator_confirmed: WBPerson2021
        Dominant: Paper_evidence: WBPaper00001133
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 20 Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000339 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: weaker than allele than n487 Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001172 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: weaker than allele than n487 Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0006830 PATO:0000460 Person_evidence: WBPerson261
                Curator_confirmed: WBPerson712
      WBPhenotype:0001220 Paper_evidence: WBPaper00001133
          WBPaper00001105
        Curator_confirmed: WBPerson2021
        Remark: HSNs (which normally undergo apoptosis only in males) die in the mutant hermaphrodites. Authors comment it seems likely that egl-1 mutations cause the cell-specific sexual transformation of hermaphrodite HSNs. Paper_evidence: WBPaper00001133
            Curator_confirmed: WBPerson2021
          HSNs undergo embryonic apoptosis in hermaphrodites. Paper_evidence: WBPaper00001105
            Curator_confirmed: WBPerson2021
        Dominant: Paper_evidence: WBPaper00001133
            WBPaper00001105
          Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006830 PATO:0000460 Paper_evidence: WBPaper00001133
                  WBPaper00001105
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00001105
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001340 Paper_evidence: WBPaper00001133
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: See Table 1 Paper_evidence: WBPaper00001133
            Curator_confirmed: WBPerson2021
          weaker than allele than n487 Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Penetrance: High: Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
          Range: 83 83 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Dominant: Paper_evidence: WBPaper00001133
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 0.75 mg/ml imipramine Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
          Temperature: 24 Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0001068 Paper_evidence: WBPaper00001133
        Curator_confirmed: WBPerson2021
        Dominant: Paper_evidence: WBPaper00001133
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 7.5 mg/ml serotonin Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
          Temperature: 24 Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001629 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: weaker than allele than n487 Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
  Reference (12)
  Method: Substitution_allele