WormBase Tree Display for Interaction: WBInteraction000000911
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WBInteraction000000911 | Interaction_type | Genetic | Epistasis | ||
---|---|---|---|---|---|
GI_module_two | Masking | ||||
Interactor | Interactor_overlapping_gene | WBGene00001170 | Interactor_type | Effector | |
WBGene00006604 | Interactor_type | Affected | |||
Variation_interactor | WBVar00089950 | Interactor_type | Effector | ||
WBVar00143741 | Interactor_type | Affected | |||
Interaction_summary | Ninety- six percent of the HSNs survived in XX animals that carry the egl-1(lf) mutation n3082, but only 11% of the HSNs survived in tra-1(e1099lf) XX animals. In XX animals carrying both mutations, tra-1(e1099lf); egl-1(n1084 n3082lf), 88% of the HSNs were present, suggesting that the egl-1(lf) mutation can suppress the lf mutation in tra-1. With respect to the HSN cell death fate egl-1 is epistatic to tra-1 and that egl-1 therefore acts downstream of or in parallel to tra-1 in the HSNs. tra-1 therefore acts as a negative regulator of egl-1 in these neurons. | ||||
Throughput | Low_throughput | ||||
Interaction_phenotype | WBPhenotype:0001172 | ||||
WBProcess | WBbiopr:00000014 | ||||
Paper | WBPaper00003631 |