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WormBase Tree Display for Interaction: WBInteraction000000911

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Name Class

WBInteraction000000911Interaction_typeGeneticEpistasis
GI_module_twoMasking
InteractorInteractor_overlapping_geneWBGene00001170Interactor_typeEffector
WBGene00006604Interactor_typeAffected
Variation_interactorWBVar00089950Interactor_typeEffector
WBVar00143741Interactor_typeAffected
Interaction_summaryNinety- six percent of the HSNs survived in XX animals that carry the egl-1(lf) mutation n3082, but only 11% of the HSNs survived in tra-1(e1099lf) XX animals. In XX animals carrying both mutations, tra-1(e1099lf); egl-1(n1084 n3082lf), 88% of the HSNs were present, suggesting that the egl-1(lf) mutation can suppress the lf mutation in tra-1. With respect to the HSN cell death fate egl-1 is epistatic to tra-1 and that egl-1 therefore acts downstream of or in parallel to tra-1 in the HSNs. tra-1 therefore acts as a negative regulator of egl-1 in these neurons.
ThroughputLow_throughput
Interaction_phenotypeWBPhenotype:0001172
WBProcessWBbiopr:00000014
PaperWBPaper00003631