WormBase Tree Display for Variation: WBVar00143741

WBVar00143741 Name: Public_name: e1099
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00003974
      WBStrain00003977
      WBStrain00004397
      WBStrain00004628
      WBStrain00004739
      WBStrain00007173
      WBStrain00026803
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00006604
    Interactor: WBInteraction000000911
      WBInteraction000003336
      WBInteraction000052146
      WBInteraction000501512
      WBInteraction000503411
      WBInteraction000503676
      WBInteraction000504099
      WBInteraction000538730
      WBInteraction000538731
  Genetics: Mapping_data: In_2_point: 87
      In_multi_point: 1248
        1249
        1252
        1420
        2786
        3110
        3111
      In_pos_neg_data: 5730
        5739
        5946
  Description: Phenotype: WBPhenotype:0000050 Paper_evidence: WBPaper00035459
        Curator_confirmed: WBPerson2021
        Remark: At 25C, 47.9% of tra-1(e1099) loss-of-function mutant embryos failed to develop Paper_evidence: WBPaper00035459
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00035459
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000295 Paper_evidence: WBPaper00064354
        Curator_confirmed: WBPerson6532
        Remark: Figure 5. tra-1 pseudomales are more resistant to heat than N2 hermaprodites Paper_evidence: WBPaper00064354
            Curator_confirmed: WBPerson6532
      WBPhenotype:0000647 Paper_evidence: WBPaper00000178
        Curator_confirmed: WBPerson2021
        Remark: About a third of the XX pseudomales can successfully mate Paper_evidence: WBPaper00000178
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000178
          Curator_confirmed: WBPerson2021
      WBPhenotype:0001025 Paper_evidence: WBPaper00000178
        Curator_confirmed: WBPerson2021
        Remark: Pseudomales also have a set of diagonal muscles (that are normally present only in adult males) Paper_evidence: WBPaper00000178
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000178
          Curator_confirmed: WBPerson2021
      WBPhenotype:0001236 Paper_evidence: WBPaper00036019
        Curator_confirmed: WBPerson712
        Remark: Pseudomales exhibited elevated levels of expression of speramtheca and sheath reporter transgenes, fkh-6::GFP and lim-7::GFP. Paper_evidence: WBPaper00036019
            Curator_confirmed: WBPerson712
      WBPhenotype:0001276 Paper_evidence: WBPaper00035459
        Curator_confirmed: WBPerson2021
        Remark: The xol-1::gfp reporter was ectopically active in tra-1(e1099) mutant animals Paper_evidence: WBPaper00035459
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00035459
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: yIs34 [xol-1::gfp] Paper_evidence: WBPaper00035459
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001277 Paper_evidence: WBPaper00000178
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: XX animals are phenotypically male Paper_evidence: WBPaper00000178
            Curator_confirmed: WBPerson2021
          XX animals transformed into low fertility males; gonad morphology variable, testes reduced in size, few sperm made; XO phenotype male, similar gonad defects. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00000178
          Curator_confirmed: WBPerson2021
        Ease_of_scoring: ES3_Easy_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001355 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: XX animal gonad morphology variable, XO phenotype male- similar gonad defects. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001357 Paper_evidence: WBPaper00026839
        Curator_confirmed: WBPerson2987
        Remark: 18% of tra-1(e1099) male gonads exhibited a disorganized morphology (Figure 7A) Paper_evidence: WBPaper00026839
            Curator_confirmed: WBPerson2987
        Penetrance: Incomplete: 18 Paper_evidence: WBPaper00026839
              Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0006794 PATO:0000460 Paper_evidence: WBPaper00026839
                Curator_confirmed: WBPerson2987
          GO_term: GO:0008406 PATO:0000460 Paper_evidence: WBPaper00026839
                Curator_confirmed: WBPerson2987
      WBPhenotype:0001663 Paper_evidence: WBPaper00064354
        Curator_confirmed: WBPerson6532
        Remark: Figure 5. tra-1 pseudomales are more resistant to juglone than N2 hermaphrodites. Paper_evidence: WBPaper00064354
            Curator_confirmed: WBPerson6532
        Affected_by: Molecule: WBMol:00004938 Paper_evidence: WBPaper00064354
              Curator_confirmed: WBPerson6532
    Phenotype_not_observed: WBPhenotype:0000070 Paper_evidence: WBPaper00031953
        Curator_confirmed: WBPerson712
      WBPhenotype:0001431 Paper_evidence: WBPaper00031953
        Curator_confirmed: WBPerson712
  Reference (24)
  Method: Allele